This is great. But, the root of the problem for most postmenopausal women is simply the lack of estrogen. You need estrogen to make bone. Men and women do. Men are mostly protected from osteoporosis because they convert testosterone to estrogen. Elderly men have more estrogen than postmenopausal women. Their levels go to near zero. It's a tragedy that more doctors don't recommend HRT for older women, at least some level of replacement, maybe not up to peak levels when they were younger. The lack of estrogen causes a lot of suffering.
When I was 32 I had a sudden cerebral spine fracture, I was diagnosed as having severe Osteoporosis(I was told my bones were like that of 80 year old); The doctors didn't bother much as I was living with Achondroplasia (Dwarfism) and they attributed everything to it.
I'm on bisphosphonate treatment (zoledronic acid), I've already had 5 of those injections and I recently learnt that it could lead to severe side effects and not that effective for treating Osteoporosis.
Meanwhile I underwent a genetic testing and the result came out as I have COMP8 mutation which leads to
Multiple epiphyseal dysplasia or Pseudo-achondroplasia; Both of which affects bones to different extent and I have symptoms for both.
I'm now looking for treatments which can help improve my bone density or at-least prevent further deterioration, CCN3 looks really promising. I even started a project to monitor bone health using BMD (Dexa) reports[1] and to submit reports for research (I'm looking for researchers in this area).
1 in 3 women over the age of 50 years and 1 in 5 men will experience osteoporotic fractures in their lifetime, According to this article more than 200 million people worldwide suffer from osteoporosis but I feel investment in bone health research is not enough.
Men are also more likely to do strength training, which also helps build bone density. Women are also more likely to regularly perform cardio/aerobic exercises, which can reduce bone density when done in excess and without adequate nutrition. Lack of estrogen is of course the root, but I think we can't dismiss behavior differences contributing to the effect. In my experience, many women do minimal to no strength training because they're worried that muscle tone will make them look masculine. Maybe this is a really bad idea to live by.
> many women do minimal to no strength training because they're worried that muscle tone will make them look masculine.
I've observed this as being a very widespread belief too, and it seems like we need to be giving women a better biology education or something, because holy shit is it wrong.
I guess it's more a misconception among the general non weight training public that this stuff is so easy you can basically develop a muscular, masculine body on accident.
For all but the youngest and most genetically blessed males it takes years of very specific diet and exercise regimes. Or steroids.
Whereas just adding some weighted squats into her routine will have immense health benefits for most women as well as making their body look more feminine and attractive.
Read of a study years ago that had postmenopausal wpmen do weight training - giving a dramatic 40% increase in bone density in 6 weeks IIRC the details.
It's not that frail people need to be inactive, but that inactivity causes frailty.
> they're worried that muscle tone will make them look masculine
Yes, this is a common concern. It would be good to show women what it looks like to workout hard six days a week for more than one year. (My point: That is an unrealistic weight lifting schedule for 99% of women.) They still won't look very masculine. Very well toned, but not very masculine. My advice when women raise this concern: "If you get too big, just ease off. Maintaining is way easier than growing."
> Women are also more likely to regularly perform cardio/aerobic exercises, which can reduce bone density when done in excess and without adequate nutrition.
What is the biological mechanism behind this statement?
I sit in a lot of doctor training sessions and the feelings on hrt have changed a lot in the last 5-10 years. It’s now well thought of and an acceptable risk. Apparently the quality of life improvement is huge compared to the relatively minor risk
No, nothing quite like HN (aggregator) exists that I've found, which is unfortunate. In this space a lot it seems most of the discussion happens on twitter, discord, or between blog posts and for the most part not in comment sections. Additionally med/bio is such a wide field I get the sense most people stick to their niche and struggle to keep up with that. However for news sites and latest:
We know microgravity is terrible for us but we don't have data on 1/3 gravity. We might be fine. Or maybe we'd be fine if we took this drug, did some weight training, and added twenty minutes of centrifuge every day.
For the trip, there are several ways we could set up spin gravity.
For more on this "we don't really have the data for anything" problem, a humorously approachable read is "A City On Mars" [0]. Also the "nobody knows how laws would work" and other interesting complications.
I just wanted to say, I really appreciate your tangent here. Space travel didn't come to my mind at all and your comment made me feel the tiny things contributing to larger stories, for a moment. Caught me weirdly off-guard.
Bone density loss in space is estimated at a loss of 1-2% of total bone density per month of microgravity exposure. The worst cases of terrestrial bone loss are around 5% of total bone mineral density per year.
In many ways it doesn't cancel out. On Mars, things weigh less but their mass is the same. So, for example, if you are walking on Mars at a normal Earth walking speed, and you bump your shin on something, the inertia of your leg as it hits the obstacle is just as great as the inertia of your leg on Earth. In general, a lot of the little physical interactions that you rely on bone strength to get through scale according to mass / inertia (and muscle strength), not weight.
You're ignoring the prime reason humans aren't going to travel to Mars anytime soon: radiation. Good luck getting there without accumulating a huge dose of hard radiation that gives you cancer. This is why we should be worrying about building human settlements on the Moon first: we can put them underground (for radiation shielding, plus other benefits like avoiding meteorites), and the travel time is so short that the cumulative radiation exposure is very low. 3 days of exposure to cosmic rays is very low compared to a year or so, or at best 6 months.
Once we have manufacturing capability on the Moon, we can build much larger ships that have some decent radiation shielding.
Of course, the low gravity causes a bunch more problems. But here again, with significant space- and Moon-based industry, we could build much larger ships with spin gravity. This doesn't help the people working on the Moon though, but at least here we could cycle them on and off the Moon every 6 months or so, since the trip is only 3 days, so they could come back to Earth and re-acclimate to 1g periodically.
Can't wait for breaking a hip at 80 to be a thing of the past. Bone health is also a contributor in life expectancy and health of a person altogether. I read a study if you can assure your bones are healthy you can assure your health longterm.
Is bone health like grip strength? Grip strength correlates with life expectancy because it is a good proxy for overall health, but if you just work on your grip strength you won't get much healthier.
Not entirely, for a pretty obvious reason: breaking a bone at an advanced age is not infrequently the beginning of the end. Not enough to make it primary (in other words, your point about bone density as a correlate rather than a determinate is basically correct), but enough that improving just bone health on a widespread basis should help with life expectancy as well.
Try googling this it is kind of interesting. Link between bone density and skin elasticity. You will find that the denser the bones the healthier the skin. We may find people who are 70 looking like they are 50.
By all accounts seems like this is a cure to age related bone loss. Almost everyone suffers from age related bone loss of some degree. Would like love to hear news about commercialisation of this.
So long as its safe. Almost always, these things don't pan out... or at least the first molecular iteration. That's the primary reason medicine is so expensive.
> That's the primary reason medicine is so expensive.
My aim isn't to make a long thread out of the topic but: while I'd agree it's one reason, I'd dispute it's primary. Demand for medicine is pretty inelastic, meaning there is generally a lot of power on the supply side to set high prices. Then you have the dynamics between health insurers and providers, the burdens of regulation and liability for adverse effects, the tendency to focus research and marketing on novel [patentable] remedies over potentially cheaper ones, and the tendency to focus on remedy over prevention. It's fairly difficult to pick a primary reason.
In my 20 mins of searching; it looks like it's CCN3 is produced by humans (https://en.wikipedia.org/wiki/NOV_(gene)) and presumably humans have the receptors for it as well - though I'm uncertain if the same effect in mice will translate to humans. Since naturally occurring genes and genetic sequences are not patentable even if they don't commercialize you could probably get a 3rd party to make it reasonably cheaply. So if it is found to work I wouldn't even worry about commercialization.
This is great. My mother had osteoporosis and I hope they come up with a therapy she can use!
However as a currently breastfeeding mother, I'm asked by doctors to take calcium supplements every day (I only remember it once a week or so), and they threaten me with future osteoporosis if I don't take it. But these researchers are saying that breastfeeding mothers' bones aren't affected despite calcium depletion?
Fwiw I've also read research that the bones are indeed affected (as measured by density) but they rebound after you stop breastfeeding. I remember that the most depletion happened in the lumbar region, and that the rebound didn't happen fully if there was "parity" (multiple kids).
The conventional wisdom and common recommendation is to supplement with calcium, but I saw at least one study stating that it is not necessary: https://pubmed.ncbi.nlm.nih.gov/9584497/
I rather suspect that if you are already eating a diet deficient in calcium, breastfeeding may exacerbate the issue, and since the supplements tend to have a poor bioavailability, taking them even if you don't need to isn't going to be harmful. Eat a healthy balance of foods and you are probably fine.
I may have a nurse for a mother, but I am very much not a doctor.
> taking them even if you don't need to isn't going to be harmful
I think, the transporter for calcium is the same used for some other minerals. So, if you're not mindful (about timing), you may be competitively blocking the absorption of e.g. zinc, which is much more precious nutritionally - zinc is very important for immune function and healing, while deficiency is common.
Calcium supplements can cause constipation, which may be not very fun after giving birth... Not to mention the implications of (lack of) quality control in the supplement market, by proxy, for a rapidly developing human being. Which substances are part of the formulation, other than calcium salts? Does the adult portion of copper or X accumulate in a mother's milk?
Not saying, you shouldn't take calcium supplements. But really, any supplement can be harmful, if consumed without need or consideration. (Fun fact: Vitamin A supplementation increases lung cancer risk!)
My water supply appears to be flush with calcium - I have to poke my shower head's holes out every few months. I wonder if it's good for me or if it's in too large of excess. Would probably help if I remembered the vitamin D more often, since you need that to absorb the calcium.
You still need to provide calcium to the body to deploy to one's own bones. This hormone apparently directs that process. It can't do that in the absence of sufficient calcium, of course, so supplements still seem like a good idea.
My amnesia is somewhat intentional. Like some of the commenters here, I'm doubtful if I should really take it everyday. Just seems excessive? Did it during pregnancy ofc, and it's not like the early days of breastfeeding when you're making almost a liter a day (kiddo is 2.5 so while still BFing, it's not an important source of food), so idk. My grandmother had like 10 kids, breastfed them all and never had bone issues. My mother breastfed us v little (<6 months all together) and got osteoporosis. I'm not at all sure how well-supported this recommendation is.
If this works and becomes a common dental procedure I will be soooo happy. Every time I go to the dentist I ask them if anything like this is coming down the pipeline and they laugh...
I'm on bisphosphonate treatment (zoledronic acid), I've already had 5 of those injections and I recently learnt that it could lead to severe side effects and not that effective for treating Osteoporosis.
Meanwhile I underwent a genetic testing and the result came out as I have COMP8 mutation which leads to Multiple epiphyseal dysplasia or Pseudo-achondroplasia; Both of which affects bones to different extent and I have symptoms for both.
I'm now looking for treatments which can help improve my bone density or at-least prevent further deterioration, CCN3 looks really promising. I even started a project to monitor bone health using BMD (Dexa) reports[1] and to submit reports for research (I'm looking for researchers in this area).
1 in 3 women over the age of 50 years and 1 in 5 men will experience osteoporotic fractures in their lifetime, According to this article more than 200 million people worldwide suffer from osteoporosis but I feel investment in bone health research is not enough.
[1] https://bonehealthtracker.com/
I've observed this as being a very widespread belief too, and it seems like we need to be giving women a better biology education or something, because holy shit is it wrong.
I guess it's more a misconception among the general non weight training public that this stuff is so easy you can basically develop a muscular, masculine body on accident.
For all but the youngest and most genetically blessed males it takes years of very specific diet and exercise regimes. Or steroids.
Whereas just adding some weighted squats into her routine will have immense health benefits for most women as well as making their body look more feminine and attractive.
It's not that frail people need to be inactive, but that inactivity causes frailty.
What is the biological mechanism behind this statement?
(And that's a significant issue in itself)
Once you get on this your only options are 1. use till you die 2. stop and face consequences of suppressed natural estrogen production from HRT.
Is that right?
https://endpts.com/
https://www.fiercebiotech.com/
https://www.statnews.com/
https://www.nature.com/nature/articles?type=news-and-views
https://pubmed.ncbi.nlm.nih.gov/trending/
https://www.eurekalert.org/
https://phys.org/
Among the dozen other serious health problems with zero/low gravity like oh serious eye problems, humans sadly aren't going to Mars anytime soon.
Then again this would need to be tested on the moon or in orbit first, might not make a difference even with the hormone.
(vitamin K2 might help too)
For the trip, there are several ways we could set up spin gravity.
[0] https://www.acityonmars.com/
The real nasty problem would be getting back to Earth.
Deleted Comment
Once we have manufacturing capability on the Moon, we can build much larger ships that have some decent radiation shielding.
Of course, the low gravity causes a bunch more problems. But here again, with significant space- and Moon-based industry, we could build much larger ships with spin gravity. This doesn't help the people working on the Moon though, but at least here we could cycle them on and off the Moon every 6 months or so, since the trip is only 3 days, so they could come back to Earth and re-acclimate to 1g periodically.
https://www.smithsonianmag.com/smart-news/explorers-will-fac...
My aim isn't to make a long thread out of the topic but: while I'd agree it's one reason, I'd dispute it's primary. Demand for medicine is pretty inelastic, meaning there is generally a lot of power on the supply side to set high prices. Then you have the dynamics between health insurers and providers, the burdens of regulation and liability for adverse effects, the tendency to focus research and marketing on novel [patentable] remedies over potentially cheaper ones, and the tendency to focus on remedy over prevention. It's fairly difficult to pick a primary reason.
Lots of organs in the body lack regeneration capabilities once you age as an evolutionary mechanism to avoid tumors.
Uri Alon's book Systems Medicine has lots of models to explain those differences depending on e.g. organ size.
However as a currently breastfeeding mother, I'm asked by doctors to take calcium supplements every day (I only remember it once a week or so), and they threaten me with future osteoporosis if I don't take it. But these researchers are saying that breastfeeding mothers' bones aren't affected despite calcium depletion?
Fwiw I've also read research that the bones are indeed affected (as measured by density) but they rebound after you stop breastfeeding. I remember that the most depletion happened in the lumbar region, and that the rebound didn't happen fully if there was "parity" (multiple kids).
So idk. I hope their premise is correct.
I rather suspect that if you are already eating a diet deficient in calcium, breastfeeding may exacerbate the issue, and since the supplements tend to have a poor bioavailability, taking them even if you don't need to isn't going to be harmful. Eat a healthy balance of foods and you are probably fine.
I may have a nurse for a mother, but I am very much not a doctor.
I think, the transporter for calcium is the same used for some other minerals. So, if you're not mindful (about timing), you may be competitively blocking the absorption of e.g. zinc, which is much more precious nutritionally - zinc is very important for immune function and healing, while deficiency is common.
Calcium supplements can cause constipation, which may be not very fun after giving birth... Not to mention the implications of (lack of) quality control in the supplement market, by proxy, for a rapidly developing human being. Which substances are part of the formulation, other than calcium salts? Does the adult portion of copper or X accumulate in a mother's milk?
Not saying, you shouldn't take calcium supplements. But really, any supplement can be harmful, if consumed without need or consideration. (Fun fact: Vitamin A supplementation increases lung cancer risk!)
Yikes. How about one of those 7-compartment SMTWTFS pill boxes? Store it alongside your morning coffee supply.
I try to eat more yogurt/kefir instead.
https://www.engadget.com/the-worlds-first-tooth-regrowing-dr...