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Kognito · 5 years ago
Very interesting given one of the lesser known complications of covid can be myocarditis in otherwise healthy individuals with few or no other covid symptoms.

In fact, it’s likely the incidence of covid-induced myocarditis is vastly underreported given it often shows no symptoms and can only reasonably be diagnosed with a cardiac MRI which is not always widely available or advised for less-serious heart conditions.

I was diagnosed with myocarditis last year and despite a negative PCR test around the onset of symptoms (light-headedness, heart palpitations, fatigue) was strongly suspected to have contracted covid.

I was lucky enough to get my first dose of the moderna vaccine a few months back and beside a few days of increased heart palpitations I’ve had no trouble as far as I’m aware, does make me wonder about getting that second dose though.

EMM_386 · 5 years ago
The human heart has a lot of ACE2 receptors, which is what Covid binds to.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239191/

I wonder if you can get myocarditits both from exposure and the vaccine. Covid is in your heart tissue, triggering an immune response. When you get the vaccine, your immune system is going to ramp up even further to deal with this Covid in your heart. This would only affect people who had prior Covid exposure it would seem.

Mountain_Skies · 5 years ago
Wonder if this will lead to an increase in pericarditis over the next couple of years. I had pericarditis when I was a teen. The explanation from the cardiologist, which probably was dumbed down for me, was that sometimes a foreign body like bacteria or a virus gets hidden in the lining of the heart and when it later gets exposed to the immune system, it causes the pericardium to get enflamed, which squeezes the heart. How long do spike proteins (SARS-CoV-2 or vaccine created) hang out if they make it to the heart? We probably don't know yet.
drcross · 5 years ago
>which is what Covid binds to.

You mean the SARS-2 spike protein binds to the ACE receptors. mRNA vaccines create the spike protein so it's going to work in exactly the same way as natural infection. Recent research from Japan is showing that the spike protein from vaccination is not staying at the injection site it can get into the blood stream (and causes blood clots as are widely reported), crossing the blood brain barrier and affecting the heart. As a healthy 30 year old I would prefer to take my risk with covid than take these vaccines. I've done enough research to know what I'm talking about and the smartest people I know have reached the same conclusion.

throwaway5752 · 5 years ago
I would "take your chances" (quotes because it's both rare and temporary according to the linked article) with the vaccine rather than risk infection with covid: https://www.health.harvard.edu/blog/the-hidden-long-term-cog...
Kognito · 5 years ago
Yeah, somewhat regret my closing comment there. I most likely will take my chances of a second dose over being infected.
oogabooga123 · 5 years ago
Very interesting! But I would rather just get infected. To each their own, I’m sure we can agree!
mrfusion · 5 years ago
COVID induced myocarditis has been thoroughly disproven:

https://www.statnews.com/2021/05/14/setting-the-record-strai...

Kognito · 5 years ago
Thanks for the article, an interesting read for sure. It’s nice to see there’s been plenty of follow-up study on this.

Respectfully, you’re wrong to say “thoroughly disproven”. Even the article ends with the suggestion that it’s a side-effect of covid, albeit a rare one.

The article’s position is more that it was overblown to worry about stopping young athletes from competing for fear of myo being a common side-effect as opposed to the ~1% rate the studies have since shown.

nicoburns · 5 years ago
Based on my personal experience, I'm pretty skeptical of this. I'm 28, healthy (or was previously), and have never previously had any issues with my heart. Got covid last April which came with quite sharp heart pain which seemed to match up very well to descriptions of myocarditis on and off for about 6 months. And I'm only just now getting to the point now where a raised heart beat isn't painful.

You might say it's anecdotal, but something had to cause that.

gulli1010 · 5 years ago
COVID is still an unfolding disaster. I doubt that anybody really understands completely what it does.
wozniacki · 5 years ago
Anecdotal or not, there have been plenty of otherwise healthy young people reporting everything from palpitations, chest pain to arrhythmia

https://www.reddit.com/r/CovidVaccinated/search?q=myocarditi... [1]

[1] /r/CovidVaccinated

https://www.reddit.com/r/CovidVaccinated/

Dead Comment

newsclues · 5 years ago
The spike protein causes cellular damage, doesn’t matter if it comes from the vaccine or virus
lame-robot-hoax · 5 years ago
Yes, but the route in which a vaccination takes place (IM injection into deltoid) should mean that much much less of the spike protein ends up in the heart and lungs vs a natural infection. As well, the overall amount of spike protein in the body will be less.

https://blogs.sciencemag.org/pipeline/archives/2021/05/04/sp...

“Consider what happens when you’re infected by the actual coronavirus. We know now that the huge majority of such infections are spread by inhalation of virus-laden droplets from other infected people, so the route of administration is via the nose and/or lungs, and the cells lining your airway are thus the first ones to get infected. The viral infection process leads at the end to lysis of the the host cell and subsequent dumping of a load of new viral particles – and these get dumped into the cellular neighborhood and into the bloodstream. They then have a clear shot at the endothelial cells lining the airway vasculature, which are the very focus of these two new papers.

Compare this, though, to what happens in vaccination. The injection is intramuscular, not into the bloodstream. That’s why a muscle like the deltoid is preferred, because it’s a good target of thicker muscle tissue without any easily hit veins or arteries at the site of injection. The big surface vein in that region is the cephalic vein, and it’s down along where the deltoid and pectoral muscles meet, not high up in the shoulder. In earlier animal model studies of mRNA vaccines, such administration was clearly preferred over a straight i.v. injection; the effects were much stronger. So the muscle cells around the injection are hit by the vaccine (whether mRNA-containing lipid nanoparticles or adenovirus vectors) while a good portion of the remaining dose is in the intercellular fluid and thus drains through the lymphatic system, not the bloodstream. That’s what you want, since the lymph nodes are a major site of immune response. The draining lymph nodes for the deltoid are going to be the deltoid/pectoral ones where those two muscles meet, and the larger axillary lymph nodes down in the armpit on that side.”

tim333 · 5 years ago
It does matter because the degree of damage is much greater if you get infected by the virus.
MauroIksem · 5 years ago
I had a horrible bout of heart palpitations / arithmia starting in may 2020. I worked from since March and was masked the entire time and rarely went anywhere but i suspect i contracted covid some how because the palpitations lasted for months. I'd have them sun up to sundown.
pcbro141 · 5 years ago
I'm curious if you were prescribed any treatment for myocarditis if you don't mind me asking?
Kognito · 5 years ago
Questions are more than welcome :)

No treatment, just a follow up cardiac MRI after 3 months which showed (thankfully) a resolution of inflammation and normal heart function. Was prescribed low-dose beta blockers if the palpitations bothered me too much though didn’t end up needing them.

As I understand it the typical approach is to wait and see since the majority of cases resolve without treatment - though I’ve noticed in the US it’s more popular to prescribe a low-dose cocktail of various heart meds. Not aware of any clinical data on their effectiveness in mild cases.

salemh · 5 years ago
>second dose There has been some discussion on that:

Delaying a Covid vaccine’s second dose boosts immune response https://news.ycombinator.com/item?id=27156859

hollerith · 5 years ago
The vaccine and the virus both expose the body to large amounts of the spike protein.
_Microft · 5 years ago
The interesting table with absolute numbers is on page 18 of [0]. Expected and observed cases are cases of myocarditis / pericarditis here. Crude rate is the number of cases per 1 million administered doses. Use landscape mode if you are reading this from a mobile device, the table is narrow enough for that.

  Age group  Doses       Crude   Expected Observed 
              administ.   rate    cases    cases

  12–15 yrs    134,041    22.4     0–1        2 
  16–17 yrs  2,258,932    35.0     2–19      79
  18–24 yrs  9,776,719    20.6     8–83     196
[0] (PDF) https://www.fda.gov/media/150054/download

delecti · 5 years ago
Crude rate seems to be observed cases per million doses administered.

So a lot more incidents than expected, but still extremely rare (0.002% of doses).

Edit: missed an extra "0" in that percent, thanks for the the catch everyone who did

thebean11 · 5 years ago
But it's only been a few months since administration, will the gap between expected and actual keep growing, or will they eventually level out?
Swenrekcah · 5 years ago
For those getting worried like I was, it’s 0.002% or one in 50,000, not 0.02% or one in 5,000.
pama · 5 years ago
You mean 0.002% not 0.02%
xvector · 5 years ago
As jb775 said, most cases simply won’t be reported. I wouldn’t be surprised if the actual rate is 10-50x higher.
_Microft · 5 years ago
Thanks! It also says that in the footnote. I added it to the comment.

Deleted Comment

jb775 · 5 years ago
But this is only reported cases. Most people wouldn't report even if they had symptoms. Others could be impacted without currently having symptoms.

Now prop this data of actual medical conditions created as a result of getting the covid vaccine up against the likelihood of getting covid in the first place, and the likelihood of having lifelong side effects as a result of getting covid. Risk of getting an experimental vaccine substantially outweighs the reward of the "protection" it provides.

nosianu · 5 years ago
Not sure why teh parent post got downvoted - we have plenty of examples right here in the various sub threads of people telling us exactly that. Almost none of all those who wrote a comment with their own anecdote seem to have reported it, many only realizing that there even is anything worth reporting after reading this discussion right here.

For most people it is perfectly normal not to report anything unless it's bad enough that they have to see a doctor. Most people already expect some side effects for a few days since we've been told to expect it, for anyone following the media.

A statement about under-reporting is not automatically "anti-vax".

sudoaza · 5 years ago
That's about the same rate as clots in AstraZeneca's vaccine.
onlyrealcuzzo · 5 years ago
So if I'm reading this correctly - that means about 1 in 90,000 people are getting myocarditis that otherwise you wouldn't expect to get myocarditis from the vaccine.

Is that correct, and if so, is that a big deal?

hnarn · 5 years ago
This feels like a pretty lazy anecdote to mention off hand without any context of how these two side effects compare in terms of lethality.
thatswrong0 · 5 years ago
Anecdote: I had this reaction to the 2nd dose of the Pfizer vaccine, saw a cardiologist and she mentioned that she’s been seeing this quite a bit after the second dose. Have had to lay low for a month, but it seems like the symptoms are finally passing.
elliekelly · 5 years ago
If you don’t mind sharing I’d be curious to hear how you knew something was wrong? If I were a man in my teens or early 20s (or even 30s!) I feel like I would chalk any chest pain up to anxiety or heartburn before I ever even considered the possibility of a heart situation. My understanding is myocarditis is usually not a big deal but it does require treatment and isn’t something you should just “wait and see” if it resolves on its own.
psychlops · 5 years ago
I had this as a side effect of covid last year. You are correct, no medication was given and they won't actually do a biopsy of your heart due to the risk so the will simply wait and see.

It feels like a big deal. I had never had heart issues and it felt like my whole system was unstable. Hard to describe really. I don't know how serious it is, however. The cardiologists just tested my heart, saw that there was no blockage and the blood flow was strong and told me to rest.

edit to add: On the second dose of Pfizer, I felt a minor version of this for about an hour in the middle of the night after a morning shot. No other symptoms beyond a strong immune response.

thatswrong0 · 5 years ago
I went to the doctor because of general shortness of breath all the time, heart rate spiking during normal activity like standing up, palpitations out the wazoo, and general fatigue. If I felt “sick” or fluish that’d be one thing.. this seemed different.
pmccarren · 5 years ago
Anecdote: I too experienced this reaction, albeit after the first dose.

Noticeable but not significant heart pain beginning approximately 4 hours after getting the first vaccine.

Speaking with medical professionals, they said symptoms should improve with time, and they have nearly completely across the 1.5 months since.

Unsure if worth noting, but I had very strong immune responses to both the first and second doses.

pmccarren · 5 years ago
Pure, unadulterated speculation:

It felt like the mRNA took hold in both my arm, _and_ my heart. Which given the proximity and paths between, is not entirely surprising.

It felt like the vaccine entered my bloodstream and was taken up, in part, by the heart. Which then started making spike protein and soliciting an immune response.

I'd really love to learn more about this, but haven't been able to find any good resources. If anyone can point me in the right direction, I'm all ears!

popotamonga · 5 years ago
What kind of symptoms makes one go to a cardiologist? Just curious
atom_arranger · 5 years ago
I'm 27 and experienced a lot of chest pains and skipped heartbeats earlier this year. One night I stood up quickly, walked a bit then lost consciousness (low blood pressure), hit my head on the way down. I had an ambulance to the ER after that, they didn't find anything wrong during that visit.

I was referred to a cardiologist, had a holter monitor, ECG, and stress test. None of those turned up any issue.

Going by what I've read about this online I suspect I may have had myocarditis from a case of COVID, but I think that would only show up on an MRI, not the tests I got. Luckily the palpitations and chest pain have mostly gone away over the past couple months.

In relation to speculation about COVID and myocarditis cases elsewhere on this page: I doubt my case will be reported because the association between COVID and heart problems didn't seem to be on the radar of any of the doctors I saw.

mannykannot · 5 years ago
Arrhythmias are perhaps the most specific indicators that you should see a cardiologist, but chest pain and/or shortage of breath on mild exercise could well be caused by a heart problem. These are some of the symptoms of myocarditis, among other things.
thatswrong0 · 5 years ago
I went to the doctor because of general shortness of breath all the time, heart rate spiking during normal activity like standing up, palpitations out the wazoo, and general fatigue.
Black101 · 5 years ago
I wanted to avoid the second dose but ended up getting it anyways... hope they don't rush vaccine approvals again... might be good in the short run, but if issues come up, it might be bad in the long run.
digitaltrees · 5 years ago
I had this after COVID in April last year right at the beginning. I suspect it is an immune reaction to the virus not the vaccine itself.
SketchySeaBeast · 5 years ago
But the Pfizer vaccine doesn't contain any of the virus, unless it's just the immune reaction to the spike protein that causes the problem?
Klonoar · 5 years ago
Interesting.

It's also anecdotal, but I have a existing heart condition and experienced no such side-effects post-dose (on either dose (Moderna)).

gabriel9 · 5 years ago
This sounds more scary then covid. At least from the people who told me how was it when they had the infection, four of my friends to be precise. Did you doctor said about any long term issues or it is too early?
thatswrong0 · 5 years ago
The thing is that some cases of COVID can result in myocarditis as well, not to mention other kinds of damage (such as permanent taste changes, lung damage, etc.). Still waiting on the echo to confirm no long term damage. I'm feeling MUCH better now, compared to even 4 days ago.

Whatever the result, I can't say I really regret taking the vaccine because it _is_ somewhat rare, and the long term side-effects of COVID are just as unknown as these vaccine side-effects. I like knowing that I'm much less likely to be a transmitter of a disease that could be fatal to others.

JPKab · 5 years ago
My mother-in-law died 9 days ago, after being on life-support for 2 weeks. All following a sudden onset cardiac arrest 3 hours after getting her second Pfizer shot. She had a fever from the shot, was sitting in the living room watching a movie with family, and her heart suddenly stopped. She was healthy and in her early 60's. The medical team, after a week, concluded it was likely vaccine induced, and reported it to VAERS.

A neighbor of mine, who is 35 year old male, had an almost exactly similar event. Because he was younger, he survived. His medical team also reported to VAERS, and the Mayo clinic is researching it.

The vaccine is generally safe, and you should get it if you aren't immune to COVID. That being said, the effort to prevent vaccine hesitancy has suppressed media reporting on these events, understandably. They are likely more common than we think, but still relatively rare.

MRNA is going to be a revolutionary technology, but we should be honest about the fact that there are going to be some individuals who will experience some extremely nasty side-effects.

throwkeep · 5 years ago
> That being said, the effort to prevent vaccine hesitancy has suppressed media reporting on these events, understandably.

This works with toddlers, but not with adults. Suppressing information ultimately leads to less trust, more hesitancy and more conspiracy theories (they were hiding X, what else are they hiding?). It'd be better if they would just be be transparent and upfront from the start.

JPKab · 5 years ago
I agree, but I understand why they are doing this. I think it's a counterproductive strategy, and dislike it. But I'm too tired of being pissed at this point to say much more on it. People in the US, at least, just don't seem to trust others to make good decisions, and this particularly goes for elite academics who dominate public health organizations and government. They treat us like toddlers because, in their minds, compared to them, we are.
myfavoritedog · 5 years ago
Yep. I know of at least five stroke or adverse heart events in my social circle or one hop out, all had been vaccinated recently.

Like you, I maintain that it’s still a lesser risk than COVID... but there seems to be a lot of media/political pushback to just acknowledging the possibility of vaccine problems.

JPKab · 5 years ago
There is also social pushback. I've had a few longtime friends who got angry with me for not remaining completely silent about this. They insist that it's just a coincidence, and since THEY got the shot and are OK, it must be safe, and I'm a horrible person for "spreading fear".

They aren't my friends anymore. I don't have room in my life for people who can't understand nuance or recognize their own cognitive dissonance.

chronolitus · 5 years ago
I definitely had this: got the first shot and felt confident, cocksure that I would have no symptoms at all being healthy and young. Woke up during the night ~8 hours after the first shot feeling a little out of breath, with strong and almost painful heartbeats. I chalked it up to being stressed, but found it strange as I had zero reasons to be stressed that particular week. I connected the dots the next day when I still had this feeling, and talked to a doctor in the family who said it was probably heart inflammation, and actually not that uncommon after the vaccine or covid infection.

I'm still glad I got vaccinated, but given that heart disease is the #1 cause of death worldwide, I'm surprised the ramifications of heart inflammation aren't taken more seriously (if the heart was permanently damaged in a small way, I'd expect it to manifest many years later).

ev0lv · 5 years ago
>>I'd expect it to manifest many years later

You're spot on. Long term risks take many years to evaluate.

cronix · 5 years ago
Dr. Bret Weinstein, Dr. Robert Malone (invented mRNA tech) and Steve Kirsch had a most fascinating discussion on youtube that touches on this, but touches on much bigger direct and indirect issues as well. I'd urge people to watch: https://youtu.be/-_NNTVJzqtY?t=591
briefcomment · 5 years ago
This was worthwhile. Not sure why you're being downvoted.
yk · 5 years ago
Slightly off topic, but it is quite interesting that US media very consistently uses "Pfizer" if the news is good and some variant of "Pfizer/Biontec" if the news is bad. The opposite holds of course for the German press, which addresses the vaccine as "Biontec" when the news is good.
bonzini · 5 years ago
Somebody even made a copypasta about it in Italian. My translation is the following:

"I’d just like to interject for a moment. What you’re refering to as Pfizer vaccine, is in fact, the BioNTech-Pfizer vaccine, or as I’ve recently taken to calling it, BioNTech plus Pfizer vaccine. Pfizer did not develop the vaccine by itself, but rather another company called BioNTech created the original formula, which went through Pfizer's clinical trials and became the vaccine we use these days.

Many people who got the vaccine refer to it as the Pfizer vaccine, without realizing it. Through a peculiar turn of events, the BioNTech-Pfizer vaccine which is widely used today is often called "Pfizer", and many of its users are not aware that it is basically the vaccine initially developed by BioNTech.

There really is a Pfizer contribute to the vaccine, and these people should partly thank that corporation, but it is just a part of what allowed them to be vaccinated. Pfizer is the distributor and responsible for clinical trials. Clinical trials are an essential part of a vaccine, but useless by itself; they can only be done once somebody developed the vaccine in the first place. So, the Pfizer vaccine can only be used because it was developed in the first place by BioNTech: the whole system is basically BioNTech with Pfizer contributions, or BioNTech/Pfizer. The so-called Pfizer vaccine should really be called BioNTech/Pfizer!"

skocznymroczny · 5 years ago
In case someone has never heard it before, above is a variant of "Stallman GNU/Linux copypasta"
dependsontheq · 5 years ago
Watching the various vaccines fail in production or in clinical trials gives an interesting perspective on what an amazing and lucky combination BioNTech/Pfizer are. So I think we should be grateful for both companies, amazing scientists and amazing engineers.
rootusrootus · 5 years ago
My skept-o-meter is twitching. I'd have to see actual numbers backing that up, as it looks much more like confirmation bias to me.
Flatcircle · 5 years ago
May wife got severe joint pain like arthritis across both arms and in other parts of her body after the Pfizer vax. She's getting several tests done and has been doing physical therapy. It was several months ago and it doesn't seem to be getting better.

Her PT said she's been seeing lots of these.

She never had covid. I hope she gets better, it's been really difficult.

dQw4w9WgXcQ · 5 years ago
Have her get blood work for various inflammation and fatigue markers like TSH/FT4/FT3, CBCs, Iron, TIBC, Serum Ferritin, VitD, IL-6, (etc) for a sanity check.

Some of it can simply be stress/anxiety which - if not managed - accumulates as whatever condition emotionally feels like it is "not resolving" and produces similar symptoms. If everything checks out, stuff like Omega3s, VitD, Glucosamine, Chondroitin and a good 3-4 week vacation to unwind are all greatly associated with reducing chronic inflammation.

I think the challenge we're all facing is Dr's are so overwhelmed with all these "inflammatory"-type conditions where some stuff can slip under the radar but they're all inclined to blame it on anxiety/depression. COVID has been a sneaky fucker wrt asymptomatic infections.

The best thing you can do is take as many stressors off the plate and give it 6-9 months. Better 6-9 months off than a lifetime of wading thru chronic issues.

Offpics · 5 years ago
8 months ago I developed severe pain, burning and stiffness in hands. Then it went to the legs and finnaly to the whole body. It got to a point where I was bedridden and couldnt eat on my own. All of my energy was put into seeing doctors and doing labs tests wich all turned out negative. I was doing PT and pain killers but they were innefective. Finally, I got a meeting with a rheumatologist that said its fibromyalgia. There are no lab tests to prove fibro diagnosis so Im still not sure about this and I suspect it may be a covid sideffect. Luckily fluoxetin helped me to be back in life, overtime it modify brain to reduce the threshold pain in a soft tissue. Covid damages nerve cells in the soft tissue (thats why people lose smell or even has body pains) so the dots are connecting. I hope your wife will get better, I know how hard it is for a whole family. Normally Im a lurker but who knows, maybe this reply will help with your situation.
vimy · 5 years ago
Sounds like this: https://mobile.twitter.com/yodoctoryo/status/137127533820710...

This doctor might be able to help, he’s been doing a lot of research to long covid.