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diob · a year ago
I've worked out my whole life (since around age 14, now over 35) and had periods where I did a lot of supplements like creatine or pre-workout.

I no longer bother with them, although creatine is one of the more well researched / "real" supplements, so you're better off with that than lots of others.

To me though they've never really done anything (besides cost money). In my opinion the best bang for your buck is drinking a coffee before or during your workout. That and make sure you get enough sleep and eat nutritious food.

mdorazio · a year ago
If we’re sharing anecdata, Creatine has very noticeable positive impact on recovery time for me. Without it, I basically have to take an extra rest day between workouts.
diob · a year ago
I'm at the point where I weight train about once every two weeks, over the course of two days (around 5 hrs each day, super focused on good form / slow movements). Cardio everyday though.

Been doing this for almost two years at this point. Used to do the more normal splits, but this has resulted in the best results / workouts of my life.

I don't recommend it necessarily, since I'm a sample size of one. I wish there were studies on this sort of thing.

nightowl_games · a year ago
I know caffeine is detrimental to my workouts because it dehydrates me and raises my heart rate. I have clear personal data on this. Creatine is well established as a substance that has a real measurable positive impact on people.
chaostheory · a year ago
It depends on your goals and heart health. If you want to burn through fat fast, then caffeine before heavy cardio workouts is the way to go (assuming your heart is in good condition)
diob · a year ago
If you have 23&me you can check your result for CYP1A2.

I have the fast processing version, but those with the slow processing should avoid caffeine at all costs.

hansvm · a year ago
That's a somewhat expected result (in the sense that averaged over the whole population I'd expect results like yours more than half the time, and averaged over the subset prone to taking pre-workout supplements I'd still expect a 20+% rate of creatine doing almost nothing). Creatine has a gender bias, doesn't work for everyone, has effects that overlap non-cumulatively with extra red meat consumption (lessening the relative effect size), and is most helpful when taken 1-2 times daily rather than just pre-workout.

If it doesn't work for you, by all means don't waste your time and money.

Other people reading might still want to give it a shot. Proper size experimental design is a bit hard, especially if you start taking creatine as you also start working out more, so keep that in mind when evaluating results.

diob · a year ago
Yes, in terms of supplements it is one of the few I'd recommend if folks want a bit of a boost.
maxglute · a year ago
Creatine for responders slightly improves your leverages by increasing water in muscles, which translates to a few % more weight or few more reps. Guestimate, 5% for weight, 10% for reps on higher rep sets. Which is to say it gives a little more headroom for intermediate/advanced lifters who needs to start dialing in program /volumes/recovery/diet in to progress. A few % of intensity or reps per set across training block makes all the difference. Which makes creatine pretty good no shit supplement if you taking lifting remotely seriously as a hobby when it cost $30-60 per year when bought bulk. Ultimately it's deciding if you're willing to shell out $5 a month to look a bit more swole, have slightly more headroom programming/dietting, or if programming and diet on point, lift slightly more than you otherwise would with the extra water balloon leverages. It's like the cheapest pay to win, pay for slight boost in gym ego/self esteem supplement along with a caffeine, which for many is enough.
grecy · a year ago
Keep in mind every body is different, and responds differently to inputs.

Creatine may not have done much for your body, but that absolutely does not mean it won't be very beneficial for others.

FWIW, coffee destroys me - I get the sweats, by heartbeat goes jittery and later in the day I crash HARD. It makes my stomach churn and grumble too. So for me, coffee is terrible advice.

atmanactive · a year ago
For me personally, coffee is true poison. I bless the day I decided to stop drinking it. It is a proper addictive substance messing with everything in your body. I'm sure studies will slowly but surely find correlation between coffee daily intake and a myriad of diseases plaguing humanity today.
diob · a year ago
Yes, absolutely. I have the "processes caffeine fast" gene according to 23&me.

For those on the other end, they should avoid it at all costs.

stemlord · a year ago
Try tea instead of coffee, sounds like you're just taking too much caffeine
ricc · a year ago
Maybe because you have been working out since 14, that's why the effect has been negligible or minimal?
diob · a year ago
Really could be, it's hard to know if my routines work because I have such a huge base, or if they're effective for everyone.
oarfish · a year ago
You are not alone in finding no benefit, and apparently about 1/3 of people are actually non responders.
memen · a year ago
Interesting! Do you have sources/studies that show this?
ratg13 · a year ago
If you’ve never tried adding a little bit of creatine in your diet, I would recommend trying it.

You will definitely notice the positive effects.

If you’re not training, don’t take weight lifting amounts, just 500-1000mg a day is more than enough.. more than that and your body will start to get larger because you will be retaining water.

voisin · a year ago
What are positive effects you have noticed if not for strength?
ratg13 · a year ago
Energy, drive, and focus.

I recommend giving it a try. You'll likely notice the effects yourself within just a few days.

whatjadat2 · a year ago
Creatine works exceptionally well for me (43m), I lift and do cardio, a couple of times a week. And if I take creatine, for a couple of weeks, I can see a noticeable improvement in energy, and body composition. It's so cheap, why would you not take it?
thefz · a year ago
The only downside with a normal intake is the weight water gain, especially when doing cardio like running or biking.

For the muscular benefits, yes, they are definitely there.

mattgreenrocks · a year ago
I have creatine on my short list of supplements to try this summer. Anything you wished you knew when starting it? Do I need to worry about buying a specific brand known for being “clean”?
boc · a year ago
I've heard anecdotal reports that it can accelerate hair loss in males (male pattern baldness). I have no clue if this has been studied but enough people have reported it across the web that it has caused me to avoid creatine personally. Any experts here feel like weighing in?
jjj123 · a year ago
Stronger By Science looked into this and the answer is basically no: https://www.strongerbyscience.com/creatine-hair-loss/
bzalasky · a year ago
Make sure to eat food before you take it, and start with 2.5g twice a day instead of 5g all at once to go easy on your stomach. The food helps slow down how quickly the creatine moves through your system. This prevents too much water from being pulled into your GI tract, avoiding undesirable symptoms (use your imagination).
worthless-trash · a year ago
As more anecdata, I eat it all times of the day and have no undesirable symptoms, before food, after food, while not eating at all, it simply doesn't have enough impact on the stomach for me to notice.
xattt · a year ago
This is likely a complete coincidence, so take my experience with a grain of salt. However… I am somewhat convinced that creatine caused me to develop appendicitis last summer about 5 days into a supplementation cycle. My best guess is that increased fluid retention (caused by creatine) caused vascular congestion at the verniform appendix.

On the (monkey’s paw) plus side, the perioperative IV fluids plumped up my muscles and gave a muscle man appearance that I was after for several days. I believe I was up 10-15 lbs in water weight when I came home.

miguelspizza · a year ago
Buy Thorne if you are really concerned about quality. Otherwise bulk supplements is fine. Creatine monohydrate is cheap and easy to produce
benced · a year ago
Be prepared to up your water intake significantly. In particular, I started sleeping near a full bottle of water.
silverquiet · a year ago
I assume you're aware of the water weight gain. Otherwise, it's effects are fairly modest.
soganess · a year ago
I don't know the first thing about these authors or if this paper was funded by a supplement company... but apparently that is a myth[1]? You may gain some water weight for a week or two, but that seems to stop.

[1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871530/

KevinMS · a year ago
I like the crystalline stuff rather than the powdery stuff because when I mix creatine with a juice the powdery stuff tastes worse, probably because the crystals just float past your tongue and you barely taste it.

My fav way to take it is put a tablespoon of crystals in about 3 fingers of juice, swirl the cup with the wrist and sip, swirl and sip, swirl and sip, until its all gone.

ropable · a year ago
Look at any pure creatine monohydrate (not the ethyl ester or hydrochloride forms) from a reputable supplier. It can cause stomach upsets in some people, but 5 grams once/day is generally well-tolerated and a sufficient dose for almost everyone. Don't expect miracles, but there is good-quality evidence for a marginal increase in sports performance in many situations, for many participants.
delhanty · a year ago
Creatine and caffeine possibly have a negative interaction - search PubMed for papers - eg

https://pubmed.ncbi.nlm.nih.gov/26219105/

I’m very slow and stiff in the mornings and I drink a lot of black coffee to mitigate that.

Then, late afternoon, perhaps 6 to hours later, I take my creatine monohydrate for the day just before my ocean swim.

thefz · a year ago
Drink water when taking creatine and maybe while eating something, or it can lead to mild stomach discomfort.
FourierEnvy · a year ago
Start now, don't overthink it. It's one of (if not the most) studied supplements on the market.
oarfish · a year ago
just buy any monohydrate. if youre paranoid, look for a brand with cgmp certification thats batch tested.

other than that, dont expect a large effect. many people dont respond, and the rest get a small benefit plus a bunch of placebo effect.

burritosnob · a year ago
I'm rapidly approaching 50 and in the gym 7 days a week 2+ hours a day for heavy lifting and cardio.

Creatine is one of the few supplements that I can say has noticeable immediate difference on or off. Without it, my recoveries take longer and I have to back down workouts to 4-5 days a week.

5mg a day... time doesn't seem to make a difference but I take pre workout. No hair loss or other side effects.

DidYaWipe · a year ago
Is hair loss alleged to be a creatine side-effect?
Perceval · a year ago
Creatine increases levels of DHT in the body: https://pubmed.ncbi.nlm.nih.gov/19741313/

DHT appears to drive hair-loss in genetically-predisposed men: https://www.ncbi.nlm.nih.gov/books/NBK278957/

Propecia's mechanism of action to stop/reverse male pattern baldness is to block the conversion of testosterone into DHT: https://www.ncbi.nlm.nih.gov/books/NBK513329/

There is not a proven pathway from creatine to hairloss, but if you are genetically predisposed to male pattern baldness then increasing the amount of DHT in your system via creatine supplementation may contribute to further hair loss insofar as DHT drives hair loss for certain men.

ekanes · a year ago
I've experienced this hair loss, and if you read the comments underneath most posts/videos about creatine, you'll find a lot of people chiming in with the same experience. If you don't have male pattern baldness though, seems you're fine.
oarfish · a year ago
It is alleged, but not substantiated.
oarfish · a year ago
I am assuming mg is a typo? 5mg would be a dose you'd almost need lab equipment to correctly measure ^^
sauwan · a year ago
Yeah, recommended daily doses appear to be closer to 5-20g per day.
ekanes · a year ago
Creatine seems acknowledged as working in the fitness community by both the bro-science and the science-based crowds.

For me, it worked very well, but I noticed I was losing hair in the shower (eep!) and stopped using it. Seems that's a thing for people with male pattern baldness. ¯\_(ツ)_/¯

nomilk · a year ago
Wonder if these were related or just happened to occur at the same time.

If creatine helps you lift more, which increases testosterone levels, which speeds up balding, then it could be (at least part) causal.

Yusefmosiah · a year ago
Replying to signal boost this. I too get hair loss from DHT-boosters such as creatine or the herb tribulus terrestris. I should note that I have a higher than average amount of body and facial hair, so likely have naturally elevated DHT levels.

When I stopped taking creatine, I did lose a few reps in all my lifts; it does work.

ropable · a year ago
If you were losing hair, it probably wasn't the creatine causing it: https://www.strongerbyscience.com/creatine-hair-loss/
taeric · a year ago
I'm always harping back to this study: https://biolayne.com/reps/issue-5/creatine-so-effective-all-...

I think a lot of people jump straight to "placebo!" to explain this, but I am growing to think it is more that your body can also prime itself in ways that mimic creatine. That is, that it is akin to how your body will change hormone profiles on just the knowledge that you have an alarm that will wake you up in the morning.

Regardless of the reason, I'm interested in reading more on this.

m463 · a year ago
Years ago I started lifting weights quite a bit. And my hairline started receeding sort of in the corners of my forehead. Stopped lifting and it stopped.

I suspect the testosterone boost from strength training.

yoyohello13 · a year ago
I lost my hair at 23 without exercising at all so damned if you do, damned if you don’t I guess.
xhrpost · a year ago
Curious, why does higher T cause hair loss if T is naturally higher in adolescence where there is less hair loss.
eggy · a year ago
I only use it when training hard, otherwise, you might as well flush it. Anecdotally, I feel I can squeeze out a bit more and I am not as fuzzy during the activity. I can't speak too much about how I feel during recovery or muscle growth. I do body weight, boxing, and range of motion and coordination drills with kettle bells and medicine balls.
pcthrowaway · a year ago
> I only use it when training hard, otherwise, you might as well flush it

Creatine has benefits for brain function as well, people who weight train are not the only people who benefit from it.

on_the_train · a year ago
People keep posting studies dating it doesn't cause hair loss. But it absolutely causes hair loss.

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OutOfHere · a year ago
I think you can add supps that lower T to DHT conversion. I have just started on this journey.
tg180 · a year ago
Taking creatine, RU58841 or CB0301 are even better than supplements.

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mgarfias · a year ago
Im losing it without the creatine so why not get the benefits.
OutOfHere · a year ago
Make sure your fasting glucose and HbA1c are normal, not prediabetic. Avoid eating or drinking anything with added sugar.

Also, avoid any supplement for now that strong raises testosterone and its resulting conversion to dihydrotestosterone. These supplements could include creatine, boron, tribulus, excessive zinc, etc. The workaround is a stack to sufficiently block the conversion of testosterone to dihydrotestosterone.

bamboozled · a year ago
Correlation is not causation…
radar · a year ago
Just be sure to cycle your creatine and be aware you need to have more water when you're taking it.
Lerc · a year ago
Given the near de facto standard use of creatine for people working out, I would have expected there to be more conclusive results available.
anigbrowl · a year ago
Conclusion: Creatine supplementation improves sit-to-stand performance, muscle function, and lean tissue mass. It is crucial to conduct high-quality prospective RCTs to confirm these hypotheses (PROSPERO number, CRD42023354929).

'Give us funding pls'

I use creatine myself and think it helps build muscle, but this is a pretty weak result. I do think it's worth researching because it's a cheap supplement and could help an ageing demographic as part of an exercise program. OTOH I'm not sure it's necessary if you're not exercising intensively or actively trying to build strength. Consistent regular light exercise and reducing sugar in your diet seems like the best way for most people to deal with ageing.

pedalpete · a year ago
Small improvements in balance and strength is valuable to the older population. One fall can significantly reduce their movements, and that becomes a slippery slope to being sedentary and then death.
riversflow · a year ago
I mean, I think it makes sense and deserves funding. Creatine has a mountain of evidence in sports nutrition, as you are likely aware, so much that it’s kinda mind boggling to me that there hasn’t been more research into treating it more like a Vitamin for the general population. The evidence is clear that your body simply can’t produce as much creatine as it can utilize. As an adamant vegetarian I admit that this is extremely good evidence that being vegetarian is unideal for our species.

In athletics, creatine is basically the first thing after protein that gets recommended to supplement. As you get older muscle mass and strength become very critical indicators of vitality and independence. It also becomes harder to build and maintain muscle as you get older. The data is clear on this. During this stage of life, giving your body everything it needs is a no brainer.

maxglute · a year ago
Sports nutrition is pretty sus as a field though. Creatine gets recommended because it's cheap and tested. Problem is most of what creatine functionally does is flood your muscles with water, improve leverages somewhat to get a few more reps on medium-high rep ranges, which has a real training effect, provided you're at level where that extra stimulus helps. Which is to say intermediate-advanced lifters who needs to seriously periodize/plan stimulus recovery cycles to progress. Which excludes 99% of genpop that wouldn't seriously strength train past novice phase at all.

If anything deserves funding/destigmatization, it would be steroids that packs on lean mass merely sitting around. Would be nice if billions gets put into steriods that doesn't adversely effect heart etc. Gen pop needs ozempic tier solutions.

justinator · a year ago
Yes absolutely: any supp. should only be reached for after an intervention to lifestyle through physical activity and diet.
viridian · a year ago
I mean yeah, pretty much every meta-analysis says this, even when they produce high quality comprehensive evidence.

The reality is that labs employ people who have families to feed, and the PI's primary job is to keep money rolling in so people can keep being paid. We are now generations removed from scientists being largely upper-class hobbyists who seek to advance humanity or make a mark on the world.

Modern science is an industrial complex that produces research papers as a product.

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