> K.C. is a director of TdeltaS Ltd., a company spun out of the University of Oxford to develop products based on the science of ketone bodies in human nutrition.
So, a specialist with ketones published a study related to ketones; which they stand to benefit monetarily from.*
That doesn't necessarily mean the research is suspect in itself - but there is a reason we need disclosures like this.
"Competing interests: The intellectual property covering the manufacture and use of the ketone ester is owned by the University of Oxford and the NIH and is licensed to TdeltaS Global Inc. K.C., as an inventor, receives a share of the royalties under the terms prescribed by each institution. K.C. is a director of TdeltaS Ltd., a company spun out of the University of Oxford to develop products based on the science of ketone bodies in human nutrition."
It depends how you do it. My current approach relies on intermittent fasting for 18 hours (save it for coffee and salty water), and accasional 24-36 hours fast (approx every 6-8 weeks). Not a keto diet, but helps with training Ketons.
I hear this from barely healthy people all the time. Omg you're having too much lemon juice, too much salt, too much meat, too much butter, too much stinging nettle tea, skipping too many meals, on and on and on.
Yet anyone I finally convince to eat like be literally changes their entire life so positively their entire world view and opinions about the medical field and government changes.
Oh yes I'll worry about my kidney because I've stopped ingesting health destroying chemicals in basically all mass food, and focused on beef and fasting.
Nothing about industries that have captured legislature?
Bayer/Monsanto (pesticide exposure, water contamination, cancer risk), Tyson Foods (antibiotic resistance, air and water pollution, respiratory illness), American Crystal Sugar Company (obesity, diabetes, heart disease), Koch Industries (pollution, weakened environmental standards), ADM (antibiotic resistance, pollution), Bunge Ltd (antibiotic resistance, pollution), Nutrien (fertilizer runoff, water contamination, cancer risk), Corteva (pesticide exposure, water contamination, cancer risk).
Swinging from one extreme to another without a good research to back it up, always a sign for a good long term move for sure. But its good, please do some research on your body for the rest of mankind, we thank and salute you. I just hope you get your meat consistently in standards that pretty much surpass what we consider "bio" in say EU or Switzerland in most aspects.
You know, there is some middle ground. In southern Europe, people have consistently healthy diets without resorting to such extremes, while eating food that tastes massively better than what a general US consumers buy / are willing to spend money on.
I just returned from 1 week vacation in Italy, thats always a trip to a small universe of healthy gourmet food. That experience is unfortunately not very transferable outside country borders but can serve as great inspiration - ie pasta ins't very healthy unless cooked al dente, then it becomes much better for the body.
I aspire to the "One Hoss Shay" approach. [0] Nothing is unnecessarily overbuilt, so everything works perfectly for a hundred years... then it all collapses to dust simultaneously. :P
I'm not sure what the stats are, but my anecdote is that two family members who did long term keto have both developed permanent renal problems in their 60s. They can now eat only very little protein.
The one person's Dr. told her that the main issue is that she was eating way too much protein. Which might mean she wasn't doing Keto quite right. But I don't know enough about the diet myself to say for sure.
Also high protein consumption is not a problem for kidneys.
There was a lot of bad science, this "protein is bad for the kidneys" comes from people who already had kidney issues from other reason beforehand, not from healthy people.
I initially tried keto just to lose weight.
But to my surprise, after about three weeks, I started feeling much clearer mentally, and overall just lighter, like something had lifted.
Back then, I thought it was just a coincidence. Now, reading this paper, I’m starting to think it might really have something to do with how the brain gets its energy.
Is it correct that the study looked at the effect of a single (large) dose of ketones, rather than ongoing consumption?
As I understand it, dosage was 0.395g per kilo of body weight (so about 27g for 70kg subject), and that was it - with measurements of brain activity before and after.
No indication of duration of effect?
I Googled and have found a product on Amazon, which is asking about 30 USD for that dose, which would make daily 900 USD a month (!)
MCT oil could be one option because it’s a shorter chain saturated fat with a number of carbons divisible by 2,
I forget the reason this is better for ketogenesis than longer chain triglycerides, Google answers didn’t seem like what I had learned about it.
Avoiding high glycemic index carbs (sugar, dairy, starch) is a big factor. Also, water: beta oxidation of fat to make the ketones, is a hydrolysis reaction
> Ketone bodies are not obligately produced from fatty acids; rather a meaningful amount of them is synthesized only in a situation of carbohydrate and protein insufficiency, where only fatty acids are readily available as fuel for their production.
they used this product in the study - looks like subjects were geven about a 1/4-1/3 of the large bottle they sell, which is around $40 https://ketone.com
Absolutely terrible science, the conclusion is a bunch of mechanistic speculation passed off as causal inference, just more keto bro grifters trying to pretend to be scientists.
• As people get older, their brain connections start to break down faster in midlife (around 40–60 years) because brain cells don’t use sugar as well.
• Giving the brain a different fuel called ketones can help keep those connections strong during this middle‐age window.
• This suggests that helping the brain get fuel in midlife could keep it healthier and slow down memory problems later on.
You can ingest ketones on their own (generally expensive supplements), but this article is more interesting in that a ketogenic diet (very low carbs) may have similar benefits.
5 bullet points, make sure I fully understand everything in 5 bullet points:
(My deliberate buzzfeedification of the Internet)
---
- Brain aging isn't linear - it follows an S-curve with key milestones: onset ~age 43, fastest decline ~age 61, then plateau.
- Insulin resistance drives it - metabolic problems (high blood sugar) appear first in midlife, before vascular or inflammatory issues.
- Neurons can't use glucose but could use ketones - gene analysis shows aging brain regions have high insulin-dependent transporters but also ketone transporters.
- Ketones reverse aging effects, but only ages 40-60 - ketone supplements significantly helped younger/middle-aged brains but did nothing for 60+ year olds.
- There's a critical intervention window - the 40s-50s appear to be when neurons are stressed but still saveable, suggesting early metabolic treatment could prevent dementia.
Readit News
> K.C. is a director of TdeltaS Ltd., a company spun out of the University of Oxford to develop products based on the science of ketone bodies in human nutrition.
That doesn't necessarily mean the research is suspect in itself - but there is a reason we need disclosures like this.
"Competing interests: The intellectual property covering the manufacture and use of the ketone ester is owned by the University of Oxford and the NIH and is licensed to TdeltaS Global Inc. K.C., as an inventor, receives a share of the royalties under the terms prescribed by each institution. K.C. is a director of TdeltaS Ltd., a company spun out of the University of Oxford to develop products based on the science of ketone bodies in human nutrition."
Nothing about industries that have captured legislature?
Bayer/Monsanto (pesticide exposure, water contamination, cancer risk), Tyson Foods (antibiotic resistance, air and water pollution, respiratory illness), American Crystal Sugar Company (obesity, diabetes, heart disease), Koch Industries (pollution, weakened environmental standards), ADM (antibiotic resistance, pollution), Bunge Ltd (antibiotic resistance, pollution), Nutrien (fertilizer runoff, water contamination, cancer risk), Corteva (pesticide exposure, water contamination, cancer risk).
You know, there is some middle ground. In southern Europe, people have consistently healthy diets without resorting to such extremes, while eating food that tastes massively better than what a general US consumers buy / are willing to spend money on.
I just returned from 1 week vacation in Italy, thats always a trip to a small universe of healthy gourmet food. That experience is unfortunately not very transferable outside country borders but can serve as great inspiration - ie pasta ins't very healthy unless cooked al dente, then it becomes much better for the body.
[0] https://www.gutenberg.org/files/45280/45280-h/45280-h.htm
The one person's Dr. told her that the main issue is that she was eating way too much protein. Which might mean she wasn't doing Keto quite right. But I don't know enough about the diet myself to say for sure.
Also high protein consumption is not a problem for kidneys.
There was a lot of bad science, this "protein is bad for the kidneys" comes from people who already had kidney issues from other reason beforehand, not from healthy people.
Back then, I thought it was just a coincidence. Now, reading this paper, I’m starting to think it might really have something to do with how the brain gets its energy.
Is it correct that the study looked at the effect of a single (large) dose of ketones, rather than ongoing consumption?
As I understand it, dosage was 0.395g per kilo of body weight (so about 27g for 70kg subject), and that was it - with measurements of brain activity before and after.
No indication of duration of effect?
I Googled and have found a product on Amazon, which is asking about 30 USD for that dose, which would make daily 900 USD a month (!)
Looks like blood concentrations peak about 30 mins after ingestion, then back to normal after about 120 minutes.
No info about how this relates to effects or duration of effects on cognition.
I forget the reason this is better for ketogenesis than longer chain triglycerides, Google answers didn’t seem like what I had learned about it.
Avoiding high glycemic index carbs (sugar, dairy, starch) is a big factor. Also, water: beta oxidation of fat to make the ketones, is a hydrolysis reaction
https://en.m.wikipedia.org/wiki/Ketogenesishttps://en.m.wikipedia.org/wiki/Beta_oxidation
> Ketone bodies are not obligately produced from fatty acids; rather a meaningful amount of them is synthesized only in a situation of carbohydrate and protein insufficiency, where only fatty acids are readily available as fuel for their production.
/s
On then off might let you get more variety in.
• As people get older, their brain connections start to break down faster in midlife (around 40–60 years) because brain cells don’t use sugar as well. • Giving the brain a different fuel called ketones can help keep those connections strong during this middle‐age window. • This suggests that helping the brain get fuel in midlife could keep it healthier and slow down memory problems later on.
You can ingest ketones on their own (generally expensive supplements), but this article is more interesting in that a ketogenic diet (very low carbs) may have similar benefits.
5 bullet points, make sure I fully understand everything in 5 bullet points:
(My deliberate buzzfeedification of the Internet)
---
- Brain aging isn't linear - it follows an S-curve with key milestones: onset ~age 43, fastest decline ~age 61, then plateau.
- Insulin resistance drives it - metabolic problems (high blood sugar) appear first in midlife, before vascular or inflammatory issues.
- Neurons can't use glucose but could use ketones - gene analysis shows aging brain regions have high insulin-dependent transporters but also ketone transporters.
- Ketones reverse aging effects, but only ages 40-60 - ketone supplements significantly helped younger/middle-aged brains but did nothing for 60+ year olds.
- There's a critical intervention window - the 40s-50s appear to be when neurons are stressed but still saveable, suggesting early metabolic treatment could prevent dementia.
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This isn't as funny or faddish or odd as it sounds at first blush.
It's a well-recognized and effect help with epilepsy. My sister went on such a diet growing up and it helped. No more 20 minute seizures.
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