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tempsy commented on VC Fund gives money back, says the market for mature startups is too weak   nytimes.com/2024/10/02/te... · Posted by u/nytesky
tempsy · a year ago
I don't think it's just a "market" thing at this point. Reality is if you're not a Tier 1 VC, which CRV really isn't, then you cannot get into good deals that would make any sense.
tempsy commented on Californian fed up with stolen mail sends Apple AirTag to herself to catch thief   apnews.com/article/airtag... · Posted by u/achristmascarl
tempsy · a year ago
I'm wondering how we haven't solved "securely leaving packages" at this point.

Having to coordinate with delivery drivers is difficult if you're not home, which is often the case unless you're WFH.

Seems like every front door should be designed in some way to securely leave packages by now.

tempsy commented on Mark Zuckerberg unveils giant Roman sculpture of his wife – AP News   apnews.com/video/social-m... · Posted by u/ssahoo
mensetmanusman · a year ago
I wish billionaires were spending more on beautiful public places with cool sculptures.

Better than hiding wealth with art in storage centers that will never be seen again.

tempsy · a year ago
do they not?

little island in NYC was funded by Barry Diller https://en.wikipedia.org/wiki/Little_Island_at_Pier_55

tempsy commented on Mice live longer when inflammation-boosting protein is blocked   nature.com/articles/d4158... · Posted by u/pseudolus
Teever · a year ago
That's missing the point. If this technique can result in longer lives for people with both good diets and not, it is a genuinely novel innovation in human life span that can't be replaced with better diet alone.
tempsy · a year ago
It's not missing the point. The point is that a lot of people live with chronic inflammation caused by poor lifestyle choices and that results in many diseases later in life, including Alzheimer's.

The point is that chronic inflammation is bad. The comment I'm replying to isn't recognizing that it's just saying "oh inflammation is fine because it's a response to injury" which is very much missing the point.

tempsy commented on Mice live longer when inflammation-boosting protein is blocked   nature.com/articles/d4158... · Posted by u/pseudolus
moh_maya · a year ago
Inflammation is typically experienced when the body is responding to an infection or injury. It is a normal, and as per current understanding, a necessary part of the body's immune response.

The Cleveland clinic has a nice, informative page if you want more information [0]

[edited to add]

The response of the innate immune system to the infectious agent / injury is what causes inflammation - i.e., for instance, fever, swelling, etc. It is a very very complex multi-cascade process, but one of the first responses to an injury, for instance, is the release of signalling molecules that results in localised swelling, slightly elevated temperature (which makes the tissue a little more inhospitable to bacteria / viruses), etc. all of which serve as the front line defense. <This is a severe over-simplification> Wikipedia has a good explanation that goes into the roles and triggers of the inflammatory response. [1]

Acute inflammation in response to infections and injuries is a good thing, and from everything we know, it is a necessary part of the immune response. The challenge is when the same inflammation response is mis-directed to target the body - for instance, in rheumatoid arthritis, and other inflammation related auto-immune disorders.

[0] https://my.clevelandclinic.org/health/symptoms/21660-inflamm...

[1] https://en.wikipedia.org/wiki/Inflammation?useskin=vector

tempsy · a year ago
There is a huge difference between inflammation in response to injury and chronic inflammation caused by lifestyle choices like poor diet.
tempsy commented on The economics of the Birkin handbag   wsj.com/style/fashion/her... · Posted by u/wallflower
michael_vo · a year ago
I went to a buy.

Hermes gives you 24 hours to go into the store and buy the item. Otherwise the bag goes to the next buyer on the rolodex.

Buyers call their friends and make it into an event. They’re literally giddy and excited to go. It’s like winning the lottery.

You’re ushered into a private room with nice couches, mirrors, a phone. You choose a scarf and wrap the scarf around the strap.

Buyers text their sales rep almost daily.

In a way it’s like a drop in the NFT space.

tempsy · a year ago
Uh not really.

The unique part here is that in order to even have the chance to buy a bag you need to develop a relationship with a sales rep and buy a bunch of other stuff. The more other stuff you buy the higher on whatever list they'll put you and when they get a bag in stock they'll give the chance to buy to whoever they have a positive relationship with and who has spent a lot of money.

tempsy commented on The economics of the Birkin handbag   wsj.com/style/fashion/her... · Posted by u/wallflower
jamesralph8555 · a year ago
This model is not unique to Hermes. Watch and car brands work the same way. Early on in these markets, you can get one of the desirable items without spending too much on undesirable items.

Some examples:

Rolex - stainless steel models are desirable and appreciate, gold models go for below msrp

Porche - Bucking the trend a bit, Porche gives you the option of paying an additional dealer markup rather than making you buy a Macan to get a GT3 RS.

Over time, this arbitrage goes to equilibrium and resellers can’t make money. It is relatively easy to get into this market so naturally it gets flooded. Profit goes to 0. Resellers also carry a risk that the item loses market value while they hold it. The only real winner here is the brand.

tempsy · a year ago
I think you're missing a key point here and that is you have no chance of buying a Hermes bag unless you have a relationship with a specific sales associate and buy a lot of other stuff there. Very few other categories of goods can get away with something like this.

In some ways Rolex is like this but Rolex is relatively high production volume and there are many situations where you can get lucky and buy one relatively easily, especially now that the hype has died down a bit from 2021-2022.

tempsy commented on Gavin Newsom wants to take smartphones out of schools   politico.com/news/2024/06... · Posted by u/koolba
andrewla · a year ago
I agree with this measure on general principles. At the very least phones should not be used in class unless on explicit instruction of the teacher.

But I do have that this is phrased as moral panic around "social media". In general, I hate the entire term "social media" because it smooshes together consumption of user-generated content, production of content, consumption of social network and contribution to social networking.

These are all very different phenomena. Kids watching Tiktok, Reels, Shorts, or whatever, doesn't really bother me at all. Producing the content bothers me a little more, but mostly as a parent -- I don't like the idea of people leaving a permanent record of all the stupid shit that they thought when they were a kid.

The other side of it, social networks, are very much a mixed bag; I'm not certain that the rise of "cyberbullying" or spreading rumors via social media is any worse than it ever has been -- we just have more visibility into it, because instead of a he said/she said about a who started a rumor, you have the screenshot of the rumor being started or spread. Maybe this makes it worse because of the indelibility, or maybe it's ameliorated by the fact that these sorts of rumormongering is so widespread and easy to see.

tempsy · a year ago
You don't have to believe social media creates mental health issues or exacerbates bullying or whatever.

The biggest problem is that it's a massive distraction from learning and also enables cheating, especially now with AI tools.

u/tempsy

KarmaCake day12572July 17, 2019View Original