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squigz commented on FDA intends to take action against non-FDA-approved GLP-1 drugs   fda.gov/news-events/press... · Posted by u/randycupertino
Aurornis · 16 hours ago
> No, what I mean is it takes pulling teeth to get someone who would die anyway, the ability to try experimental drugs even with a doctor’s prescription.

This topic came up in another online community (which I'm intentionally not mentioning) a lot a few years ago. I left a comment about why giving experimental drugs to terminally ill patients is not a simple or obvious idea like many would assume. I got some very long, very intense replies from someone who was dying of a type of cancer who believed he had a good shot at recovery if he could get his hands on an experimental drug. He had all of the links and papers to prove it.

I remember trying to take it all in and reconsider my position.

A few years later, there was a post from his wife that he had died. It was a very sad situation. I clicked some of her links and found that he had a blog where he had written a lot. He actually did go through with the process of requesting the experimental drug and his request was granted. However, the drug not only didn't work, it had caused some irreversible damage to his body that made his final months a lot more painful and difficult than they had to be.

Apparently the "compassionate use" exemptions are not as hard to get as the anti-FDA writers have led us to believe. The harder part is often getting the companies to provide the drugs, because they know the risk profiles and uncertainties better than anyone and aren't always interested in letting terminally ill patients experiment on themselves outside of the process.

squigz · 6 hours ago
Sounds like you might be talking about Jake Seliger, and indeed, his and Bess' fight to get treatments was rather eye-opening for me too.

Jake's blog where he posted throughout his entire illness: https://jakeseliger.com/

Bess' blog: https://bessstillman.substack.com/

It was a heartbreaking story to follow, and one that hit me a lot harder than I thought it would when Jake died.

squigz commented on Pentagon cutting ties w/ "woke" Harvard, ending military training & fellowships   cbsnews.com/news/pentagon... · Posted by u/alephnerd
cornhole · 10 hours ago
half of America thinks the public school system is there to turn kids gay and trans
squigz · 9 hours ago
No, "half" of America does not think that.

Also, is Harvard part of the "public school system" now?

squigz commented on Substack confirms data breach affects users’ email addresses and phone numbers   techcrunch.com/2026/02/05... · Posted by u/witnessme
parable · 11 hours ago
I'm fairly sure even mentioning the name of the forum isn't allowed on HN. It should be trivial to find it yourself, though. I also replied to someone else with the CSV headers if you're only trying to find out what exactly was included in the leak: https://news.ycombinator.com/item?id=46932380

Also, keep in mind that this is a partial leak. The data was scraped from some leaky endpoint which was patched out before every user could be scraped. Only users who were in the partial leak received emails (I have two accounts, only one received an email). If you're a Substack user but didn't receive an email, I'd assume you're not in the leak. Troy Hunt should load it into HIBP eventually, and those concerned can check there if they don't want to seek the leak out on their own.

squigz · 9 hours ago
> I'm fairly sure even mentioning the name of the forum isn't allowed on HN.

I'm not sure this would be the case? I've seen plenty of links to content of questionable legality shared on HN.

squigz commented on Cannabis usage in older adults linked to larger brain, better cognitive function   medicalxpress.com/news/20... · Posted by u/PaulHoule
tartoran · 4 days ago
It’s cheap for ocassional use, yes. However, heavy users spend quite a bit for their habit since their tolerance level is shut. Also I never found it to be addictive but that’s my own bias, there are a lot of users who can’t go to sleep without it, not to mention daily and frequent use.
squigz · 4 days ago
> It’s cheap for ocassional use

This can be said about any drug, but even then, heavy use of weed vs other drugs is absolutely cheaper, especially these days if you live in an area where it's legal and/or are willing to grow it.

squigz commented on Todd C. Miller – Sudo maintainer for over 30 years   millert.dev/... · Posted by u/wodniok
rileymat2 · 6 days ago
The problem is if I was going to do that with the open source projects I use, it is more like a penny a month * 1000 projects.
squigz · 6 days ago
This is why I feel like a missing piece of Patreon/Kofi/whatever is the ability to say "Here's $x; divide it automagically amongst the creators I'm currently following"

Sure, I think a lot of those donations would amount to a few pennies or so at once, but I feel like a lot more people would be willing to support creators if they didn't have to constantly choose which to support.

squigz commented on Roots is a game server daemon that manages Docker containers for game servers   github.com/SproutPanel/ro... · Posted by u/Kerrick
squigz · 8 days ago
Created 3 weeks ago. 27 commits, half of which seem to be version bumps.

Why should anyone want to use this, OP?

squigz commented on The hidden engineering of runways   practical.engineering/blo... · Posted by u/crescit_eundo
dyauspitr · 13 days ago
Some of it is stock but Grady has a lot of custom animations and miniature scale replicas in his videos all the time.
squigz · 12 days ago
Writing off Practical Engineering's videos as "stock footage" is utterly hilarious to me.
squigz commented on The state of Linux music players in 2026   crescentro.se/posts/linux... · Posted by u/signa11
atoav · 12 days ago
For me peak musicplayer UI is still my customized foobar2000 setup on Windows.

I need a waveform, a playhead, a good browser that can do both metadata based libraries and dumb folders fast and without lagging, a way to build/save/view/load playlists and a way to queue songs.

Most players are just too basic or make the wrong or to many assumptions about my collection. Or the interface is just too cute and dysfunctional for my actual daily use.

This means on Linux I currently use either mixxx or just VLC player, but I surely haven't tested every possible mediaplayer.

squigz · 12 days ago
I think ncmpcpp might check all those boxes, with the caveat that it's a TUI player. Have you tried it?
squigz commented on The state of Linux music players in 2026   crescentro.se/posts/linux... · Posted by u/signa11
rpnop94 · 12 days ago
None of the current solutions work for someone like me. I have multiple versions of the same album so the UI needs to incorporate labels, catalog numbers, etc. and the playlists need to accommodate disc subtitles and grouping. The only two players that allow me this functionality are both on Windows so there's little available for the collectors such as myself.
squigz · 12 days ago
Which players on Windows are you talking about?
squigz commented on France passes bill to ban social media use by under-15s   rte.ie/news/europe/2026/0... · Posted by u/austinallegro
djtango · 12 days ago
Just the other day the FT put out an article that the current generation of graduates are so serially online that they freeze or go silent when faced with basic small talk questions.

I have encountered this for myself.

A few months ago New York banned phones at lunch and was discussed on HN [1]

We live in times where parents and schools no longer have the authority to enforce behaviour and social media is peer pressure from the entire world.

These bans are obviously heavy handed but hopefully they are a reversion back to an equilibrium that gives our young a chance to properly develop...

[1] https://news.ycombinator.com/item?id=45822539

squigz · 12 days ago
> We live in times where parents and schools no longer have the authority to enforce behaviour

...What? They certainly can, if they're banning certain behavior?

u/squigz

KarmaCake day4303July 24, 2023
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