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hrq commented on US Intel   stratechery.com/2025/u-s-... · Posted by u/maguay
vel0city · 9 days ago
Billions in grants have already been cancelled. Lots of research is losing its funding.
hrq · 8 days ago
Agreed. Also the biotech industry is largely getting defunded. Venture funds are pointing dollars elsewhere so fewer new companies are being started, while more biotechs are being started in China.

Most new drugs come from biotechs nowadays (not all of them, not GLP-1’s). But many do. If that innovation is happening in China and not the US today then it will create an issue in several years. We will not control our supply chain for a critical set of goods.

hrq commented on US Intel   stratechery.com/2025/u-s-... · Posted by u/maguay
themgt · 10 days ago
I’ll be honest: there is a very good chance this won’t work .... At the same time, the China concerns are real, Intel Foundry needs a guarantee of existence to even court customers, and there really is no coming back from an exit. There won’t be a startup to fill Intel’s place. The U.S. will be completely dependent on foreign companies for the most important products on earth, and while everything may seem fine for the next five, ten, or even fifteen years, the seeds of that failure will eventually sprout, just like those 2007 seeds sprouted for Intel over the last couple of years. The only difference is that the repercussions of this failure will be catastrophic not for the U.S.’s leading semiconductor company, but for the U.S. itself.

Very well argued. It's such a stunning dereliction the US let things get to this point. We were doing the "pivot to Asia" over a decade ago but no one thought to find TSMC on a map and ask whether Intel was driving itself into the dirt? "For want of a nail the kingdom was lost" but in this case the nail is like your entire metallurgical industry outsourced to the territory you plan on fighting over.

hrq · 10 days ago
I believe something similar is happening in drug development right now. It may take less than 5, 10, 15 years to see the impact to the US. But from someone who has a vantage point to see it across many parts of the industry, including having seen the evolution of Intel / TSMC, I think it is a very similar story. Right now is like 2007 (or maybe even a bit later) for therapeutics. In the future, we will look back on this year as the year we gave it up.
hrq commented on Machine Learning and Ketosis   github.com/arielf/weight-... · Posted by u/ddv
hoodwink · 9 years ago
As a long-term ketogenic eater (10 years), here are my top simple tips. Unfortunately they were not gleaned using machine learning.

1. Watch your protein. Most people when first going keto will eat too much protein and not enough fat. Protein has an insulinogenic effect when eaten in quantity. Keep protein below 8 oz per meal. Don't be afraid to eat more fat.

2. Avoid cheese. Yes, it's technically low carb, but it repeatedly throws me and my girlfriend off (also a low carber).

3. Avoid nuts. Yes, like cheese, nuts are delicious. But they're a slippery slope. Life will be easier if you avoid them.

hrq · 9 years ago
I've been trying to be low carb for the last couple years and I think it's overall gone well, but I really struggle with what to eat still.

I hear your points about protein, cheese, and nuts, but then what do you eat? Can you list out a few complete days of your meals?

hrq commented on The FDA's notes from its visit to Theranos' labs don't look good   businessinsider.com/fda-d... · Posted by u/bpolania
iandanforth · 10 years ago
Document numbers? Release dates? This seems more like red tape and nitpicking rather than a substantive challenge to a technology. It's stories like these that guarantee I would never try to start a company in biotech or recommend a friend join one.
hrq · 10 years ago
TBH the FDA is the least of the various hurdles to get a great biotech going. The FDA has (surprise) largely been spot on. Theranos is just a fraud. If you are not risk tolerant that's fine, it's a reasonable position. But, there are plenty of people who are willing to actually get outside the anonymous video chat / messaging whatever echo chamber and make real inventions happen in the world that make a real difference to real people.
hrq commented on Tesla Model III to challenge BMW 3 Series   autoexpress.co.uk/tesla/8... · Posted by u/mshafrir
martin_bech · 11 years ago
Cue link to a Tesla Model S beating a BMW M5. http://youtu.be/vvHTN0Yi1t4

You might want to do a testdrive yourself..

hrq · 11 years ago
I test drove the Telsa S (along with several other cars in the general $100k range) and found the acceleration to be astounding, but the handling to be uninspired and the interior actually felt cheap to me. There's nothing like the immediate acceleration from the Tesla, but the M5 just seems like a better overall car today. The M5 is a total beast, but still incredibly comfortable. Wouldn't be hard for Tesla to change the interior. Just felt hard to swallow paying $100k and sitting in a plasticy feeling interior. Also the handling in the M5 is a completely different animal than anything I experienced in the Tesla. Again, not impossible or maybe not even hard for the Tesla to update in the future, but the M5 just feels like a better car today.
hrq commented on Google Ventures Leads $130M Round For Medical Software Company Flatiron Health   blogs.wsj.com/venturecapi... · Posted by u/brandonb
hrq · 11 years ago
Wow! How about that? Congrats guys - what a time to make a difference in cancer.
hrq commented on How Long Have I Got Left?   nytimes.com/2014/01/25/op... · Posted by u/conesus
melling · 12 years ago
"And then my health began to improve, thanks to a pill that targets a specific genetic mutation tied to my cancer."

Isn't tailoring drugs to specific mutations the next big revolution in medicine that we've been waiting for? Steve Jobs had his DNA sequenced to help fight his cancer.

http://appleinsider.com/articles/11/10/21/steve_jobs_had_his...

hrq · 12 years ago
http://www.technologyreview.com/view/519686/steve-jobs-left-...

Another article describing a business that was started around this concept and seems to be having an important impact in medicine.

hrq commented on Twitter / paulg: We installed Nest thermostats ...   twitter.com/paulg/status/... · Posted by u/ph0rque
foobarian · 12 years ago
I never heard of it before, but it seems like it addresses the major issues I have with programmable thermostats, which is that their UX is invariably like something from the 1960s.

Now if you could disable all that learning crap then we'd be talking.

hrq · 12 years ago
You can disable that stuff. Once you turn learning off you can use it either as a normal thermostat or as a pre-programmed one.

I actually use our Nest as a normal thermostat that just looks great and can connect with my phone. It's awesome. I also like that it tells us our energy usage relative to everyone else.

I bought it because it's far and away the best looking thermostat out there and because it can connect with my phone. LOVE it for those reasons.

hrq commented on In Treatment for Leukemia, Glimpses of the Future   nytimes.com/2012/07/08/he... · Posted by u/thecoffman
tokenadult · 13 years ago
Here's some good commentary on this case in a blog post "The future of cancer therapy?" from a cancer physician in today's Science-Based Medicine blog:

http://www.sciencebasedmedicine.org/index.php/the-future-of-...

"While the story is basically one long anecdote that shows what can be done when new genomic technologies are applied to cancer, it also shows why we are a very long way from the true 'individualization' of cancer care.

. . . .

"Taking the results of the sequencing of the entire genome and RNAseq data and analyzing them allows scientists to probe the genome and transcriptome of cancers in a way that was never before possible. It produces an enormous amount of data, too, terabytes from a single experiment. At cancer meetings I’ve been to, investigators frequently refer to a 'firehose' of data, petabytes in magnitude. Indeed, the sheer quantity of data from these experiments challenges the bandwidth of universities doing them, and, in fact, it’s not at all uncommon for the preferred means of sending experimental data to be to load up a hard drive with the data and send it by the quaint but effective method of overnight mail to other investigators because it’s faster and more reliable that way. Not surprisingly, serious computing power and major advancements in computer algorithms have been necessary to develop the methods of analyzing data from these experiments.

"What I’m trying to convey is that what WUSTL did for Dr. Wartman was not a little deal. It was a big deal that took a lot of resources and effort and likely cost well over $100,000. Apparently it was paid for through research grants, and Dr. Ley claims that no patients were neglected while all that sequencing and computing firepower were transferred to sequencing Dr. Wartman’s cancer genome and transcriptome, having done the same thing for a previous patient."

In other words, the glimpse of the future that we may be able to derive from this case shows that the future is still far off, and the steps to reach the future are enormously expensive. More details are available in other paragraphs of the linked Science-Based Medicine post.

hrq · 13 years ago
Seems like people and companies are already starting to address the cost issues to make this a more accessible and scalable process. I'm thinking of things like DNAnexus to help with the computational stuff. Also surprising they didn't mention any of the companies doing this work (i.e. this isn't just an academic exercise anymore).

u/hrq

KarmaCake day43October 21, 2010View Original