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glaugh commented on Sports supplement creatine makes no difference to muscle gains, trial finds   unsw.edu.au/newsroom/news... · Posted by u/geox
cj · 5 months ago
> no change in my life has been more important besides kids

Quick note to add: if you're reading the above comment and you still want kids, it's important to note that loss of fertility is one of the most significant side effects of testosterone (or any steroid). There are additional medications that can reduce the risk (and possibly reverse it after fertility is already lost), but it's not guaranteed.

glaugh · 5 months ago
Yeah. A lot of the warnings on the side of the box are based on really suspect data from a very long time ago (Abraham Morgentaler at Harvard is my go-to for this) but the point cj raises is legit.

When a man takes exogenous testosterone, their endogenous production (in the testicles) plummets. This is largely fine, but the production in the testicles also leads to sperm production, and that gets lost.

The solution to this is HCG, which stimulates some testicular production. But it is not a perfect solution, and recently CA has made it much harder to use HCG for this purpose (which was always off-label).

glaugh commented on Sports supplement creatine makes no difference to muscle gains, trial finds   unsw.edu.au/newsroom/news... · Posted by u/geox
maerF0x0 · 5 months ago
> Steroids don't magically give you the gains, you still have to put the work in.

That's not an entirely fair description of the situation actually.

Imagine the 4 groups from the cross product of WorksOut?(Yes/No) cross Steroids?(Y/N).

It's intuitive, obvious, and supported by the data that The WorksOut(Y) + Steroids(Y) Group reliably gains more muscle over time than other groups. And similarly that the WorksOut(N) + Steroids(N) group gains the least (including losses too!) .

The interesting groups are WorksOut without Steroids, vs Steroids without WorksOut.

The sad truth is those on steroids, though sedentary, gain more muscle than those who workout without steroids.

Here's the source of what I'm talking about from Jeff Nippard's Youtube channel https://www.youtube.com/watch?v=VD9p9tEP9RE around 4:05

And it's important we educate folks about who is likely on them and what's realistic naturally. Because many young people are innudated with drug enhanced bodies on social media and think that's possible without steroids (and their negative sideeffects). It's particularly troublesome in the case of sexual selection and competition, for example using the hetero normative pairings, when young women are attracted to the steroidal bodies and when young men are pressured to take damaging gear to compete with peers who are. (There's the equivalent analogues for other sexual pairings/preferences).

glaugh · 5 months ago
My personal experience, having had low testosterone for much of my life and then now being on testosterone replacement therapy:

- It’s obvious to me that I (n=1) gained a ton of muscle and lost a ton of fat very quickly without having done dramatic changes in workouts at first

- It also made it waaaay easier to work out. I used to hate it bc I was exhausted all the time, and now I don’t really mind, and sometimes even enjoy it. In actual practice pulling these variables apart is hard

PSA: T levels have declined markedly over the past generation or two. But when one tests for low T, the goalposts move bc every time a new population is studied for setting benchmarks (generally every decade or two), the definition of clinically “low” is moved to the new 2.5%ile of that study, such that someone in the current 3rd %ile (considered A-okay by most doctors) would have been in maybe 2.4th %ile (considered red alert by most doctors) using the previous benchmarks (made up numbers but roughly right).

(This is a dumb approach, the binary magic of the 2.5%ile (2 standard deviations), and it frustrates me greatly bc i was denied care bc my first test was 2.4%ile and 2nd was 2.6%ile and thus i was told i was fine bc of the 2nd result and offered anti-depressants instead).

Fixing this is not about muscles, it’s about having energy to live life fully and not be cranky.

So if you’re constantly tired, consider testing for this. And use a functional doc, as in my experience from shepherding 5-10 other folks through this process, the standard doc knows little about this stuff and thinks that having a condition like this is binary

Sorry, a bit off-topic, but no change in my life has been more important besides kids, so I try to spread the word where even somewhat appropriate

glaugh commented on Alzheimer's biomarkers now visible up to a decade ahead of symptoms   newatlas.com/brain/alzhei... · Posted by u/01-_-
glaugh · 7 months ago
> …small amounts of clumping tau protein in the brain and cerebrospinal fluid, which lead to Alzheimer's disease.

I don’t think this should be stated as a proven fact anymore, given the doubt now cast over the amyloid hypothesis

This is a nice summary of the case: https://podcasts.apple.com/us/podcast/plain-english-with-der...

glaugh commented on Why is Warner Bros. Discovery putting old movies on YouTube?   tedium.co/2025/02/05/warn... · Posted by u/shortformblog
wbl · 7 months ago
What is the similarity between the Dominicans and the Jesuits?

Both were started to fight heresy: the Dominicans the Cathars, the Jesuits the Protestants. Both were started by soldiers. Both have unique spiritual disciplines.

What's the difference? Meet any Cathars lately?

glaugh · 7 months ago
I went to a Jesuit high school but am not religious now. But I still have a soft spot for the Jesuits. They tend to be liberal (relatively speaking) and taught extensively about social justice, and generally are very education-oriented.
glaugh commented on Avoiding outrage fatigue while staying informed   scientificamerican.com/po... · Posted by u/headalgorithm
slantedview · 7 months ago
The Economist is not exactly a neutral source of information, and is very much pro-big business, which has caused it to take horrible positions on many important issues throughout its long history, such as overthrowing democratic governments, supporting dictatorships, etc.
glaugh · 7 months ago
I’d say it’s pro economic development. Like they express concerns around the decline of anti-trust enforcement.

I’m sure it’s true that they used to advocate dictators, but in the 30 years of reading it as my primary news source, they’ve always seemed to me to be very consistently on the side of liberalism (in the older sense of the word) and very concerned about democracy

glaugh commented on I had to take down my course-swapping site or be expelled   linkedin.com/posts/jdkaim... · Posted by u/jdkaim
move-on-by · 8 months ago
It’s a funny thought, but looks like a nonstarter:

> SLS cannot represent a student when the opposing party is another UW-Seattle, Tacoma, or Bothell student or UW entity.

glaugh · 8 months ago
I know very little about lawyering, but I could imagine a UW-alum or Seattle-area lawyer advising pro bono bc of generosity or good publicity on a very newsworthy case

Anyone on here friends with a UW-alum or Seattle-area lawyer who might be interested but doesn’t read HN?

glaugh commented on Carlsen quits World Rapid and Blitz championship after dress code disagreement   chess.com/news/view/2024-... · Posted by u/throwup238
ttyprintk · 8 months ago
The title of the dress code PDF is helpful—-something like “proposal of Ms B Marinello”.

https://web.archive.org/web/20200925160442id_/https://www.fi...

But I wonder if another player complained to the administrators.

glaugh · 8 months ago
Possibly this is not the actual dress code? Or I'm missing something.

3.a. The following is acceptable for men players, captains, head of delegation. -- Suits, ties, dressy pants, trousers, jeans...

3.b. The following is NOT acceptable for men players, captains, head of delegation. -- Beach-wear slips, profanity and nude or semi-nude pictures printed on shirts, torn pants or jeans...

glaugh commented on Task-specific LLM evals that do and don't work   eugeneyan.com/writing/eva... · Posted by u/ZeljkoS
jacobr1 · 9 months ago
Here is a short example that came up for me last week.

I had a set of documents I wanted to classify according a taxonomy that is well known (so it is exists in the training data of all the major llm models I tested)

If I have prompt like, `You are an expert classification system. Using the Classification Approach Foo, consider the following and output the category in JSON format, such as {"class":"bar"} `

This works ok, but it works much better if I tell it to output {"class":"bar", "reason": "baz"} and improved with some other approaches like adding "related_class" or "parent_category" which would otherwise be redundant.

Also including some few-shot examples helped, but the biggest benefit came from the "reason" field. Trying justification or other synonyms seems to produce the same output.

I suspect this is something similar to CoT.

glaugh · 9 months ago
Great, thank you (and hedgehog), that makes sense
glaugh commented on Task-specific LLM evals that do and don't work   eugeneyan.com/writing/eva... · Posted by u/ZeljkoS
hedgehog · 9 months ago
As other people pointed out here you can also add "verbosity sinks" as text fields in structured output, recently I've also been experimenting with tool calls to support guided self-talk in a way that doesn't necessarily all accumulate in the context (e.g. if not all the tool parameters get echoed back).
glaugh · 9 months ago
Thank you (and teMPOral) for these comments, this sounds potentially useful to me.

I hate to ask this, but I'm struggling to find any thorough posts or articles or papers about this, do you have any links you could point me toward?

u/glaugh

KarmaCake day1937August 27, 2011
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