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Posted by u/jpgvm 3 years ago
Ask HN: Beating depression with or without anti-depressants?
I realize this is somewhat of a taboo topic but I feel like if there is anywhere we can have a real discussion on mental health it's going to be HN.

I have been struggling with depression for as long as I can remember.

Life has taken me on ups and downs but as far as I can can tell I'm fairly lucky, well-off and have every reason to be happy.

Unfortunately I'm not.

I wake up with a pit in my stomach that I carry around all day and no matter how hard I try I just can't shake it.

It also gets really bad in waves to the point where I nearly can't function but most of all it makes me procrastinate on almost everything.

I usually end up using all my effort just to be a functional member of my team at work.

The sad part is that I know that if I didn't have this condition and I was able to sleep when I wanted to I could be many times more productive, not only at work but also in life.

The obvious solution to these problems are SSRIs and other anti-depressants. These drugs are very powerful but have really bad side-effects for most people that take them.

For these reasons I am completely shit-scared of them. I see them as my option of last resort but increasingly I feel my options running out.

I have tried therapy, I have tried all sorts of coping mechanisms but nothing solves the problem permanently.

So HN, what has your experience been with depression? Have you tried the drugs? What worked or didn't? Have you been able to triumph without chemical assistance and what did that look like? Is my utter terror of these drugs warranted or should I just bite the bullet and try them?

frankincense · 3 years ago
PLEASE do not read any of these people's advice. Talk to a MEDICAL PROFESSIONAL, preferably a DOCTOR. DO NOT trust your mental health to strangers on the internet, be it reddit, or hacker news, or whatever.

If you are based in the US and live nearby a university they usually have good counseling services and the infrastructure to refer people even if you're not attending the school. Search "{school} counseling services" on google.

hn_throwaway_99 · 3 years ago
I think the reason you are getting so many "I disagree" responses is because many of us have had awful experiences when it comes to medical professionals and mental health.

It's important to understand the economic pressures in psychiatry. I went to see a psychiatrist, who prescribed me antidepressants. They helped give be a baseline level of energy to get me out of my acute depression, but they addressed none of my underlying issues that caused me to get depressed in the first place, and a couple years later I was right back in the depths again. And I'm fine if my dr's economic model meant he couldn't do psychotherapy with me, but he never recommended I get therapy, and that's what I'm so bitter about regarding him.

I've heard it said that giving antidepressants to a depressed person, without any therapy, is like giving amphetamines to a tired person: yes, they may temporarily cure your "tiredness", but what you really need is to go to sleep.

So while I don't think OP should take detailed advice from random strangers, he should be aware of his options. Talk to a therapist first to see if they can uncover what some of the root cause issues are. Be open to medication - some mental issues really are largely organic in nature, but a good doctor and therapist will know they are just one tool to improve your mental health.

wheelerwj · 3 years ago
> I think the reason you are getting so many "I disagree" responses is because many of us have had awful experiences when it comes to medical professionals and mental health.

> I've heard it said that giving antidepressants to a depressed person, without any therapy, is like giving amphetamines to a tired person: yes, they may temporarily cure your "tiredness", but what you really need is to go to sleep.

I don't even know where to start with this comment. This whole thread should be booted waaaaay off HN.

A few people have problems with medical professionals. It's true, assuming you're in america, we're definitely not the best. But you find a few 1,000 people online with bad experiences (obviously, because people with good experiences have moved on and don't spend their time researching that issue) and assume you have a complete picture but you're only looking through a pinhole of information returned with biased search results. You probably aren't googling, "how many people have gotten their lives back after using anti-depressants?"

> he should be aware of his options.

Yeah fine, be aware. Talk to professionals, get second and third opinions if necessary. Take a holistic approach to your well-being. But please lets not glorify google medicine here.

danamit · 3 years ago
I found strangers online to be more effective than doctors, simply because they read to much on the matter, then they interact too much with you.

I basically got diagnosed online by 2 different people about 2 different issues, one is biological, and the other is mental. And they were right. This is nerds out there who read about topics constantly, way more than the average doctor, not even close. So a stranger can help.

Also depends on where you are located, doctors can be dogmatic, there is countries that give antibiotics before extracting teeth, and there is those who don't. Countries who believe ADHD can stay into adulthood and go undiagnosed, and others who believe it is impossible to have ADHD as an adult.

In the ADHD case, depends on who what countries are right, some group might be living a lie taking meds for an illness that doesn't exist, or the other group is suffering being undiagnosed with ADHD despite seeking help, the doctor just tell them its not possible to have ADHD.

I would rather research and try to solve my issues over hand my situation to the medical zeitgeist of my country. Also I am sure if I give myself days of research, thinking, talking to people, comparing situations over some doctor talking to me for 15 minutes then giving me the two meds given to everyone who enter that door (SSRIs and benzos), I might probably be up into something.

I will never stop researching my medical issues, I will never trust my doctors fully, I will always google, research, ask, ask second opinions. Some doctors care more than others, some doctors are capable more than others, you have no idea which ones the RNG gave you.

jliptzin · 3 years ago
This is a great approach
zephyrthenoble · 3 years ago
This isn't a video game. Your sample size of one is not indicative of the greater population. Don't cause people to mess up their health by appealing to the notion that they can do better than trained medical professionals. This is dangerous.
dimal · 3 years ago
Sorry, you are very very wrong about this. Have you ever talked to a _medical_ professional about depression or any mental health issue? They generally don't know what they're doing. Medical professionals only have one tool in their arsenal for depression: antidepressants. So a medical doctor will likely prescribe them, whether that's appropriate or not. Antidepressants are no joke. Sometimes they can help, but they can also cause really strange side effects, like increasing the possibility of suicide. And does the average doctor monitor all their patients regularly to make sure they're not having suicidal thoughts? Nope. And doctors generally won't know anything about the difficulty of getting _off_ the antidepressant if it didn't work.

Asking for advice on the internet is a very valid strategy, given the terrible state of mental health care in the US.

kayodelycaon · 3 years ago
Not OP, but I have. If you go to a family doctor in the US, they really aren’t qualified or trained in treating mental health.

My psychiatrist was fairly clear on what was what and which things needed to be treated with therapy and which medication could help with. (Medication helps symptoms, it does not cure.) Finding the right medication would take months or years and will not solve everything. There will be side effects that I needed to monitor and report. And so on.

When seeing any doctor, you are your own best advocate. It helps to come prepared, knowing your family history, and things you are struggling with.

Researching medications can help, but most people are not qualified to use them without supervision, myself included.

Note: This is assuming you need medication. It was fairly clear in my case medication was absolutely required to at least treat psychosis.

I prefer to refer friends to a therapist or psychologist, who do not prescribe medication.

APhoenixRises · 3 years ago
Granted everyone's case is different, but my doctor went forward with medications only as part of a comprehensive plan to deal with my mental health which included seeing a therapist and committing to an exercise program (it sounded silly to be before, but exercise can be for some people can be nature's antidepressant). I'm on a 6 week to 3-month schedule of follow-up visits with my doctor to keep track of where I'm at mentally. Yes, there are absolutely doctors out there that will toss pills to people and send them on their way, but I don't think it's the majority. I also vet doctors the same way I would a mechanic or anyone else who is going to be doing important work for me. It can be hard, but there are doctors who care about doing the right thing out there.
heavyset_go · 3 years ago
> Sometimes they can help, but they can also cause really strange side effects, like increasing the possibility of suicide

This type of side-effect is thought to be mediated by 5HT2C activation when initially starting SSRIs, however, over the period of about two weeks, 5HT2C receptors downregulate and reach an equilibrium that can cause the effect to diminish or go away entirely. As an aside, there's research that suggests that abnormal amounts of upregulated 5HT2C receptors are present in suicide victims.

One of the reasons Prozac is recommended as a first line of treatment, besides the fact that it has a long half-life, is because of its 5HT2C antagonism that can block 5HT2C from extracellular serotonin activation from SSRI effects.

There are also plenty of antidepressants that don't typically cause that particular problem, especially if they aren't typical SSRIs or serotonin agonists.

SkyPuncher · 3 years ago
> Sometimes they can help, but they can also cause really strange side effects, like increasing the possibility of suicide

FWIW, my understanding is this has little to do with the drugs and mostly to do with the recovery process.

In a deep depression, you might have suicidal thoughts, but lack the will to take action on those thoughts (because depression takes away your motivation). As you a person comes out of depression, they tend to recover their motivation before their suicidal thoughts dissipate. This creates a situation where a person with suicidal thoughts now has motivation - which means they have the potential motivation to take action on their suicidal thoughts.

The important nuance of this is anti-depressants don't necessarily make your suicidal thoughts _more_ suicidal. In fact, it's likely, anti-depressants are making your suicidal thoughts _less_ severe. However, they do increase your motivation before they can fully eliminate suicidal thoughts.

I'm not saying you should take an anti-dpressant willy-nilly. It's just BS to be fear mongering like this without considering why this situation happens.

_moof · 3 years ago
> Have you ever talked to a _medical_ professional about depression or any mental health issue? They generally don't know what they're doing.

And you think a random stranger knows any better? I know firsthand that the medical profession has serious limitations in its understanding of and ability to treat depression, but no way in hell am I taking some rando's advice over that of any of the many doctor's I've seen.

frankincense · 3 years ago
You're a frontend engineer, not a doctor. You're not qualified to give advice on medicine.
kappuchino · 3 years ago
I DISAGREE. For this reason: I was given antipressants by my (former) doctor for a moderate anxiety "phase". It was escitalopram. And it did well for me - within a day! When it came to end the medication, I was told to just stop taking it. Which I did. But I should not have - I had anxietiy "echoes" over the following YEAR, really weird stuff. So I started to read about the medication: Studies have shown the longer you take time to reduce it in steps (like 10% of the former dose) the better is the time after. But since this is burdensome, its rarely suggested and also people need to "cut" pills to have the exact dose for their reduction.

My current OPINION is: Until you have read studies and got some plausible experiences from people with the same medication, one doctor alone isn't a good source for taking medication.

I will only take medication in the future if life wouldn't managable without, but not for issues that just take time.

SketchySeaBeast · 3 years ago
But as grandparent suggests - talking to a forum full of strangers is not doing research.
SkyPuncher · 3 years ago
I just want to echo the other commenter. You had a completely incompetent prescriber.

Tapering SSRIs is the normal unless a provider has alternative indication it shouldn't be done.

inter_netuser · 3 years ago
You had an incompetent prescriber.

Tapering doses for all sorts of medications are routinely done, and any pharmacy can handle such an rx. If they can't - you don't want to go to such a pharmacy anyway.

Dead Comment

sillysaurusx · 3 years ago
Must every conversation about depression devolve into yelling? There’s not even any new information here.

No one with depression is going to read this and go “Oh, you’re right.” It’s self gratification disguised as help.

Everyone knows they really ought to see a doctor. There are plenty of reasons to be scared to. An untimely hospital visit bankrupted me thanks to no health insurance. My sleep doctor had to cut me a deal of only $50 per visit instead of the usual $150, and she really cared about me. I was part of a lucky few.

I think what rubs me wrong about your advice is that it’s positioned at the expense of all other advice. No one’s allowed to have an opinion except yours. Smart people like OP see right through such things, and it tends to push them away. Which is particularly troublesome when the advice is good, like yours is here.

hsn915 · 3 years ago
This is really weird advice.

Yea it's mainstream and to be expected under legaleeze circumstances.

But it's not the kind of advice I would give to a friend whom I'm genuinely concerned about.

Have you known anyone who was depressed and managed to get better by following the advice of a generic "profressional"?

I haven't.

Quite the opposite. I've seen people get worse in one dimension or another by taking medication or following other professional advice.

kayodelycaon · 3 years ago
I have told friends to see professionals. Mostly getting a good therapist. Medication should be a second line for the usually encountered forms of depression.

It’s worked.

oaktrout · 3 years ago
I would wager you know many people who have gotten better after seeing a "professional". Mental health isn't often discussed openly so you would probably be shocked at how many high functioning people are on SSRIs (doctors, lawyers, engineers, etc).
heavyset_go · 3 years ago
> But it's not the kind of advice I would give to a friend whom I'm genuinely concerned about.

My advice to friends and family experiencing such issues is to take those issues seriously, and to see a doctor about them.

jac241 · 3 years ago
Probably many people you know have seen a doctor for depression and gotten better, they’re just not telling that to the guy who says things like you did in your post… Very stupid take here man…
ad404b8a372f2b9 · 3 years ago
You have an unhealthy relationship to medicine if you refuse to even read the advice of other people. I've been treated by hundreds of medical professionals and worked with dozens and I can assure you they do not hold any secret undying truth about human health. Modern medicine is primitive and brutal, we are fumbling buffoons when it comes to the human body and its ills, especially in the realm of mental health. If you don't believe me watch an orthopedic surgeon do his work (if you can stomach the electric saws and the hammers).
frankincense · 3 years ago
There's a lot of dangerous advice in these comments.
Trasmatta · 3 years ago
Doctors aren't always effective at treating depression. Especially if they use a therapy modality or medication that doesn't work for you. That doesn't mean you shouldn't talk to them, but it's also helpful to read experiences from from other people.

My opinion, doing both is good. Consult a professional and read about other people's experiences.

At the very least maybe somebody mentions a form of therapy that you've never heard of that you can ask your doctor about, or find a therapist that specializes in. If you ignored everyone's advice online you'd never even hear about that.

Personally, I'm starting Internal Family Systems therapy, which has seemed more promising for my psyche than many other modalities. But there are countless others. CBT is a good place to start, but doesn't work for everyone.

inter_netuser · 3 years ago
50% of doctors are by definition below the average.

In reality, roughly 3-10% are good, the rest just go by standard guidelines only and/or punt you off to someone else.

spaetzleesser · 3 years ago
Some of the most depressing experiences I have had was to look for a therapist when I was really depressed. I went to several and never felt that they understood me or even cared about what I was thinking. I honestly think they made me worse.

I have learned way more useful info on online forums from people who were going through the same experience. Yes you have to be discerning but the advice “go to a professional” is thoughtless. There are a lot of incompetent people working in mental health. I am sure it’s easier if you have tons of money or just lucky to run into a good therapist. But already being down and then being disappointed by the professionals is devastating. At least it was for me.

R0b0t1 · 3 years ago
There's enclaves of doctors who e.g. think everything is some obscure type of bipolar disorder. Listening to doctors above all else is, surprisingly, not a good idea.

For everyone who had their life turned around by medication I have met two or three who either did not see improvement or had negative side effects on all options tried so they gave up.

Some drugs, like the typical or atypical antipsychotics that treat bipolar or rapidly oscillating bipolar, have the side effect of reducing your energy and making you more passive. It's hard to pick out the effects of some drugs from actually solving the issue or just making you more likely to not cause a fuss.

ls15 · 3 years ago
> PLEASE do not read any of these people's advice. Talk to a MEDICAL PROFESSIONAL, preferably a DOCTOR. DO NOT trust your mental health to strangers on the internet, be it reddit, or hacker news, or whatever.

I find this comment so overused, ignorant and dismissive. In my city it can take months to get a 20 minute appointment with a specialized doctor, while the internet is full of useful and scientific information and helpful people. That isn't even saying if the doctor really understands your problem or just dismisses it (had that often enough), like you dismiss other people's anecdotes. What are people supposed to do while they are waiting for an appointment for months with acute issues? I'd rather spend days myself and read the same information that a doctor (hopefully) would read in order to work on the problem before it gets worse or kills me.

So yes, try to talk to a medical professional at least once if you have the chance. If not or if it does not help, keep doing what you need to do and try to get the best information that you can find.

dominotw · 3 years ago
>Talk to a MEDICAL PROFESSIONAL, preferably a DOCTOR.

why ? they don't really have a solution for it other than prescribing anti depressants. I don't see why they need to see a doctor.

Deleted Comment

jerome-jh · 3 years ago
I too can only advice the OP to seek a true medical advice with preferably a face to face consultation. Now my personal experience: anti-depressants do work and often with little or no side effects. A doctor will prescribe what is best in your particular case. Allow for a few weeks for the effects to be felt, then you can decide if you want to continue using the product or not. It is best to take again medical advice at that time. Do not self-medicate! Many plant based products have side effects for often a low effect.
fdgsdfogijq · 3 years ago
I don't trust doctors, and I have seen many people medicated for no reason at all. They basically just go by the book to avoid any sort of malpractice.
RickJWagner · 3 years ago
Yes!

Depression can be caused by hormonal imbalances. It's tricky to get things right-- see a doctor!

alienalp · 3 years ago
You may be correct about not trusting mental health with strangers. But at the and taking anti depressant or not taking it up to you. Doctor cannot weight pros and cons of taking anti depressant for you.
oneplane · 3 years ago
A doctor can definitely weigh it for you, that is practically the whole job... A doctor can (most of the time) not "make" you take medicine, but again, that is not the point either.
renewiltord · 3 years ago
Clueless comment. You don’t understand explore vs exploit. You are not qualified to give advice on the subject of whom to consult. Please do not try. Your advice is really bad.
weakfish · 3 years ago
This isn’t really a charitable response imo
yuuu · 3 years ago
My doctor is a fucking idiot. I also went to a university counseling service and they didn’t do shit. Never followed up or anything after the one consultation appointment I had.
TameAntelope · 3 years ago
https://www.betterhelp.com/

An option if you prefer an entirely-online experience.

But yes, your mental help is not worth asking strangers on the Internet for help. You deserve better than what we here can offer.

loteck · 3 years ago
Am I the only one scratching my head over people, who are themselves giving advice on this website, saying not to take advice from people on this website? Seems self-defeating.
a-dub · 3 years ago
now that everyone thinks covid is over (hopefully it is), we can go back to having a healthy skepticism towards healthcare under capitalism. this is a good thing.

asking for advice and personal stories regarding navigating an issue as complex as depression and the way it's treated is not only prudent, it's smart.

a good healthcare provider is one that is fully willing to discuss unorthodox strategies found via independent research. take advice from the internet and find a provider who is willing to discuss it with you.

joeman1000 · 3 years ago
Honestly: go and talk to a doctor you trust.

My opinion (not a doctor): What is wrong in your life? Are you:

+ Working too hard

+ Commuting

+ Not exercising and taking care of yourself

+ Eating a diet with lots of processed foods

+ Using drugs and alcohol as a crutch

+ Overweight

+ Not resting regularly

+ Sleeping poorly

+ Have other health issues not addressed

+ Without genuine friends

+ Without a good partner

+ A certain age without kids

+ Spending too much time on social media

+ Spending too much time watching TV

+ Not engaging in hobbies, such as reading

+ Neglecting talking to family

+ Wanting to do something different in life but ignoring it

+ Harbouring regret, judging yourself and generally being cynical

+ Judging those around you too harshly

+ Not trusting people

Etc.

I fully understand that depression causes people to avoid addressing problems like I’ve listed. I’ve been there too, and it is not easy to climb out of the hole. It’s a positive feedback loop though: you start neglecting things (maybe due to time constraints), you lose a bit of happiness/stability, you neglect more things & so on. The hard part is to break out of the loop and start ticking these boxes. Start small and don’t judge yourself harshly if you slip.

Really do examine my small list and see if any of these things are pulling you down. If there’s something there you can’t fix, don’t beat yourself up on it. That’s the last thing to do. No one can be perfect, so don’t worry.

valenaut · 3 years ago
As another person who has struggled with depressive issues at various points in my life, I really like your list. I have ticked every one of those boxes at one time or another; all of them brought me down, took effort to fix, and improved my well-being when fixed.
bckr · 3 years ago
Including having children?
tootie · 3 years ago
You can't always just pin depression on lifestyle. There's a strong biological component that influences your susceptibility to depression and every other mental illness. Some people fall in a pit over what might seem like a minor inconvenience to someone else. Some people get depressed over absolutely nothing.
joeman1000 · 3 years ago
I agree, but I prefer to start with these things. Smaller measures should only be passed over if they fail. I know what you mean though, I know people with mood issues like what you describe. It’s impossible to make a recommendation that suits everybody.
konspence · 3 years ago
I suspect some of these are meant to get a rise, but I'll bite.

> + Commuting

Prior to 2020 this was the vast majority of all jobs, including tech. Most got by just fine. And today still encompasses the majority of jobs, so I would argue this is classist.

> + Neglecting talking to family

Many people have reasons not to talk to family that end up with positive mental health outcomes. Sure, it can be negative, but this seems exclusionary.

> + A certain age without kids

C'mon. This isn't the 1940s.

Please be careful when putting out lists like this.

This is juxtaposing genuine, universal indicators of depression alongside subjective ones, which when read by the wrong (misinformed, uncertain, etc.) audience, could lead to adverse outcomes.

hoseja · 3 years ago
Most of those are symptoms and not causes.
dominotw · 3 years ago
what about sex ( or lack thereof). that caused me depression at somepoint in my life.
joeman1000 · 3 years ago
Of course. I think this stems from my point about not having a good partner. I don't think that sleeping around will help depression.
pasabagi · 3 years ago
> For these reasons I am completely shit-scared of them. I see them as my option of last resort but increasingly I feel my options running out.

I was in the same boat.

Don't listen to the haters. Anti-depressants are amazing. Most of the people who 'cured' their depression through some kind of cheap trick turn out to have been self-diagnosed.

Anti-depressants, if dosed and chosen properly, have basically no side effects. The only change is you get to experience life like neurotypical people. So like, exercise is fun, not a form of torture. Emotions are OK, not the harbringers of the apocalypse.

Living with depression is awful, and it almost never goes away. It's also extremely dangerous. Look at the stats: depression is a dangerous medical condition. Anybody telling you to take some herb or read a book is on the level of the people who prescribe smoothies to cancer patients. Get medical advice. Take drugs if they are prescribed. Depression massively increases your risk of death from all causes. Anti-depressants have like, a slight chance of causing dry skin.

chas · 3 years ago
This isn’t an accurate description of the possible side-effects. Anti-depressants can cause meaningful side-effects including changes to appetite, difficulty regulating body temperature, nausea, changes to sleep, and akathisia. They are also very, very not fun to quit abruptly if you run into an intolerable side-effect. That said, nothing that you said about depression is wrong and the effects of untreated depression can be far worse than the side-effects of anti-depressants. It can just be hard for people to tell what is normal and what is abnormal and potentially caused by their medication, so they should be informed so that they can switch medication if they run into side-effects. (And know if their doctor is not providing them with good information.)
pasabagi · 3 years ago
Yeah, re-reading my post, I probably should have expanded on the 'if dosed and chosen properly' part. Obviously, if you take the wrong dose, or have an adverse reaction, it's going to not very fun. I recommend talking to a psychiatrist.

That said, my first go-around with anti-depressants was a hugely overdosed prescription of venlafaxine from an overenthusiastic doctor, which is pretty side-effect-tastic, so my eyes were rolling out of my head and I was falling off chairs for a week and it was still far superior to being depressed.

Not taking anti-depressants because you're worrying about the side effects is like not wearing your motorcycle helmet because there might be a scorpion in it. The risk of dying from depression is really high. The risk of suffering from anti-depressants is fairly remote.

slaymaker1907 · 3 years ago
I tried a whole host of anti-depressants including several SSRIs and an SNRI and all gave me many horrible side effects. At times they were necessary evils, but right now I'm doing pretty well on a low dose of gabapentin. In particular, they tended to both make me sleepy during the day and dramatically reduced the quality of my sleep at night. I also ended up getting tremors and RLS. In the end, I think most of these symptoms were due to the medications decreasing the effective amount of dopamine in my brain (they increase seratonin, but due to how seratonin and dopamine interact, this can decrease the effect of dopamine in the brain; they really need to be in balance with one another).

I also take methylphenidate (Ritalin) for ADHD and it is MUCH easier to stop stimulant medication in my experience compared to anti-depressants. And while stimulants affect sleep, I found the SSRIs to be much worse in this regard since they made me sleep poorly regardless of when I took the SSRI unless I skipped a day of the SSRI (and I was on the lowest possible dose).

Not only do these medications have side effects, they have severe side effects, at least for some people.

pasabagi · 3 years ago
Depends on how you rate side effects. My experience of depression was feeling so physically awful I wanted to die, just to make it stop. In comparison, even the 'extreme' side effects from rapid anti-depressant withdrawal (shocks, vomiting, dizziness, etc) are very mild.

I get that's not everybody's experience. However, my feeling is that if you shop around until you can get the right dose and the right meds, the only side effect pain is when you start, and when you stop or draw down your dose.

The real danger of starting meds is that it can give a severely depressed person the motivation and wherewithal to commit suicide, so I do think it's worth starting them in a setting where you're not going to be alone. Still, I'd say that's less a 'side effect', and more just an effect of having severe depression and suddenly not feeling so debilitated that you can't do anything about it.

In general, I just find the conversation around anti-depressants completely unhelpful and baffling. People focus on the extremely long-tail side effects, and ignore the massive bump in the bellcurve that is a depressed person either committing suicide, or just living a totally miserable life until they die from some substance abuse problem. People who are diagnosed with depression do not live good lives without medication. The statistics for life expectancy, etc, are just awful (it's worse with stuff like schizophrenia or bipolar). So all the stuff about antidepressants making you fat or whatever is just totally irrelevant.

insickness · 3 years ago
I was averse to anti-depressants as well. Ended up depressed and started self-medicating myself for a few years with weed and alcohol. Finally gave in and started taking the minimum dose of Celexa and, holy fuck, do I wish I had started taking them sooner. They changed my life. I took them for about 7 years and then went off them when I didn't need them anymore. Side effects were very minimal. Dampened sexual pleasure slightly. But it also made me more effective at work and better to get things done in my life.

My advice is try it. Talk to a psychiatrist and go on a minimal dose for a few months. Get therapy while you're going. If it doesn't work, it doesn't work. But it really could change your life.

The_rationalist · 3 years ago
> Anti-depressants, if dosed and chosen properly, have basically no side effects WTF is that bullshit ? SSRIs destroy libido and possibly permanently (see r/pssd) MAOIs have many side effects NRIs are not effective NDRIs can cause tinnitus. Stims are cardiotoxic and usually not prescribed for depression. TCAs are not an action mechanism and therefore fall in the above categories. Atypical mechanisms are not better either. The only ones with low side effects either cause some sedation (mirtazapine, agomelatine) or have dubious effectiveness. The only one that stands out is moclobemide and maybe bifemelane. The latter is only available in japan. The former has low efficacy. hence for someone that don't want side effects, only moclobemide make sense, or ultra atypical stuff that has probably low efficacy. One of the only atypical that might be potent is SAM-e but who wants to play with his DNA methylation ? 9 mebc is phototoxic unfortunately as it is very promising otherwise. edit: it's true though that testosterone is apparently as effective as SSRIs and with less side effects.

What should be said though is that there are some great anxiolytic out there, it's just that no one knows them, e.g opipramol, emoxypine, etifoxine

inter_netuser · 3 years ago
This is the reason why some people suggest not to listening to any comments. A lot of stuff here are factually incorrect:

  1) MAOIs are safe, and Parnate specifically is extremely effective. However, requires a special diet to adhere.
  2) Stimulants ARE prescribed very frequently to augment antidepressants in difficult cases, especially in people with serious illness.
  3) Moclobemide has every effect of an MAOI in effective dosages, including diet restriction. There are no effective drugs without side effects. Moclobemide is not thought to be particularly effective(mostly because on-label dosage is far too low), there is a reason why it's used infrequently.
  4) Etifoxine might be great for some, but it has significant risks of liver injury. There is a reason why Valium is still one of the most common anxiolytics prescribed worldwide.

hoseja · 3 years ago
There's MANY classes of antidepressants. You probably got prescribed one of the more pleasant modern ones.
tomatowurst · 3 years ago
Dangerous advice. Anti-depressants are band-aid solutions. Depression isn't an imbalance of "chemicals", it has been marketed that way for decades to sell pills.

As soon as you are off them, you will likely relapse back into depression. While it can help someone that is in immediate risk, it does not solve the core issue of what depression is which requires a holistic, non-conventional view that Western medicine shuns, and is doomed to never address.

Stop treating it like a medical issue and it will open doors. There's a reason Western society is riddled with drug abuses, addiction, mental health issues while other societies is riddled with war, poverty, and diseases.

robertakarobin · 3 years ago
Everyone experiences depression differently. SSRIs made a tremendous difference to me and my mom where therapy and various other treatments did not.

Please be careful; this attitude places the blame on the person experiencing depression, and feeling guilty about being depressed is a vicious cycle that can have catastrophic effects.

There are some for whom depression is a product of their environment. For some of those, a "tough love" approach may work. But there are also those for whom depression is a physical condition that requires medical treatment

j-krieger · 3 years ago
> Depression isn't an imbalance of "chemicals", it has been marketed that way for decades to sell pills

Medical professionals have been finding that in cases of clinic chronic depression, the patients brain doesn't produce nearly enough endorphins compared to others. Also, antidepressants are from a time where we didn't yet produce problems to sell the solution and they have helped millions of patients.

But I guess you know something we don't?

Dead Comment

blaser-waffle · 3 years ago
> So HN, what has your experience been with depression? Have you tried the drugs? What worked or didn't? Have you been able to triumph without chemical assistance and what did that look like? Is my utter terror of these drugs warranted or should I just bite the bullet and try them?

A lot of friends have ended up on prozac or other drugs, with profoundly hit or miss results.

I've struggled at times, but found that vitamin D, magnesium, zinc, decent amount of protein, and good sleep did a lot for me. Regular outside activities, even if just walks, or exercise also a lot for me.

Keep in mind I live in Western Canada, so my walks often happen in -30C weather.

Also just finding something that produces joy was big. Not fun, not cool -- joy. Making less money and doing more things that bring me joy made a big difference. Most of the people I know making "the big money" are miserable people.

alberth · 3 years ago
Couldn’t agree more on Vitamin D (and if possible get sun, even if it’s fake sun).

Also, avoid caffeine like coffee etc. Caffeine can make things worse.

EDIT: why the downvote?

Jtsummers · 3 years ago
I don't know why you were downvoted, but I will say that for me caffeine has not directly impacted my depressive episodes. The closest is when it impacts my sleep. I've learned that poor sleep quality and insomnia are my first obvious signs of a depressive episode, but the causal direction is not always straightforward (depression -> insomnia, insomnia -> depression? Both have happened, they feed on each other). So keeping caffeine to the morning and early afternoon is sufficient in my case.

However, caffeine does heighten my anxiety (with or without the impact on sleep). Maybe I should quit caffeine, but I like my morning coffee ritual so have no plan to right now. Instead, I take periodic breaks from caffeine to make sure I'm not addicted again. If I can go a few days without caffeine and without getting a headache, then I'm good. If I can't, then I'm probably consuming too much and it will (or already has) exacerbate my anxiety.

jrgoff · 3 years ago
I have also found vitamin D to be important for my mental health. In the past I found probiotics extremely helpful for my mood as well, though lately they haven't seemed to effect me much (seems to have changed after I had a course of antibiotics, so perhaps the reason they had been effective was related to an interaction with some bacteria?)
emerged · 3 years ago
Depression runs in my family but daily exercise completely reverses it. I’m referring to 60m+ of cardio average per day. Anytime I go more than 2 days without exercise, I’m immediately under a dark cloud.

I’ve heard plenty of people say it doesn’t work for them. I have to assume they’ve actually tried it for a length of time and it’s true. But it’s at least worth finding out of it works for you before resorting to medication.

GuardianCaveman · 3 years ago
When I had two major crisis hit at the same time last year I made sure to get out of bed no matter how I felt and go run for about 45 minutes rain or shine every day. I had been through stress anxiety periods before and found it to work wonders. It kept my head above water last year and things are much better now and I am still exercising training for a half Ironman. It’s so amazing how much it helps. Also walking it sounds like bs but it really works for me.
tucaz · 3 years ago
There is evidence supporting that. Not a lot but there is.

https://pubmed.ncbi.nlm.nih.gov/24026850/

honksillet · 3 years ago
That’s a lot of cardio. Especially as you age? Do you have a contingency for injuries?
Jtsummers · 3 years ago
Not GP, but I'm integrating lower impact cardio into my routine both to prevent injuries now and to get myself into good habits for when running may not be possible (or reasonable). Right now I run or walk (I took the winter off from running, so I'm getting back into it) and row each weekday. I have a bike and a trainer for it, which I will put next to the rower soon (I have had too many close calls to be comfortable with road biking anymore). There's a gym with a pool across the street from my house so I also plan to get back into swimming, but I need to work on shoulder strength and mobility first.
emerged · 3 years ago
Cycling and other forms of cardio can be done well into old age. Sure I’ll eventually be forced to wind down, but that doesn’t seem relevant to whether I do lots of cardio at my current age.
timbit42 · 3 years ago
A bungie rebounder (mini trampoline) is a good exercise. It gets your heart rate up and exercises pretty much every muscle in your body while being low impact and easy on your joints. NASA did a study back in the 70's and claimed it was more efficient than jogging with less joint stress.

Even if you can't stand, you can get health benefits from bouncing while merely sitting on it. Even people who are paralyzed can benefit by sitting on it and be bounced by another person.

You can watch videos or chat while doing it. You don't have to worry about bad weather. It's almost silent so you can do it even while others are sleeping in the same room. You can hold or wear weights while doing it to increase strength. It doesn't take much space and some have folding legs for storing behind or under other furniture and some even fold the frame for storage or transportation.

mFixman · 3 years ago
If you think 60m per day is a lot of cardio, you need to improve how you get your heart rate up.

Treatmills and stationary bikes are boring; going for a run or hopping on a bicycle works much better.

playcache · 3 years ago
I likely do double that and have done for 20 years now. For me its simple, run on soft surfaces (trails) or a treadmill if its really rough out there.

Dead Comment

devonbleak · 3 years ago
Had Major Depressive Disorder and Generalized Anxiety Disorder for many years.

I went through a couple different psychiatrists and multiple combinations of meds before I found something that was mostly effective and without major side effects for me. Along the way I went through times where I was severely overmedicated and couldn't really function but quickly recognized that and worked with my psychiatrist to move onto another treatment. You have to give stuff a shot and see how it goes for you, chances are the first thing you try is not the thing that's going to work.

The psychiatrist that I stuck with was the one that suggested I should also see a therapist. My take is you need both. I went through a few different therapists before I found one that worked for me. They helped me develop the tools I needed to break out of the cycle and take control of the anxiety and depression.

Ultimately starting to take care of myself physically was the biggest impact and the thing that really got me off the meds and "graduated" from therapy. But I wouldn't have been able to get started on that without the meds and the therapy.

jemfinch · 3 years ago
I went through mild (and not professionally diagnosed) depression a few years back. No suicidal thoughts, no pit in the stomach, just a complete lack of desire to do anything at all. Crystallized apathy. Before seeing my doctor, I figured I would anticipate his questions: he would ask, "Do you get any exercise?" And I would say, "No, I walk up two flights of stairs and back down those flights of stairs each day and that's about it." And my doctor would say to me, "Get some exercise, and see what happens."

So I got some exercise. I bought a bike and put it on a trainer. I rode a few times. I loved riding my bike when I was young. That helped, a little. I think it helped me take my next step.

I'd been coaching my 9yo son at soccer for a year or so, but I never played soccer myself. So I decided I'd try playing a local soccer pickup game.

That was the trick for me. I don't know why. But suddenly I found motivation. Just enough to play soccer. Once a week, and then twice a week, and then three times, and now as many times a week as I can fit into my schedule. I lost 10#, 20#, 30#, even made it to 40# before the pandemic and found more motivation in other areas of life as well.

Soccer hurts. A lot of games I can barely shuffle through my garage after driving home. I was 39 when I started playing and I'm 41 now. I'm no spring chicken. But the mental and physical engagement of playing soccer, even just pickup soccer, has thoroughly enriched my life.

I have a friend who's a psychiatrist. I talked to him about this. He told me that I correctly anticipated my doctor's response. Exercise is the first line of defense and the first treatment suggested for depression. And it doesn't take much to try it and see if it helps. Your depression sounds worse than mine. Maybe you can walk before you run.

You shouldn't be afraid of the drugs: let the doctors handle that. But if you prefer to try something before drugs, exercise is the clear choice.

xtracto · 3 years ago
This is important advice. I was just diagnosed with a micro-stroke due to covid & AZ vaccine. My vascular neurologist doctor basically prescribed 3 things: aspirin, exercise and diet. Including for depression I got after the fact.

If you look for the 'solution " to most chronic ailments, exercise is usually at the top of the list.

So OP, if you dont exercise at least 40 mins every day, start with that. If you already do that, then your condition might require antidepressants

gdfgjhs · 3 years ago
When I had depression, I had similar symptoms like you. I had same deep pit in the morning and unable to sleep at night.

I tried exercise, read Feeling Good book, took different vitamins etc. None of this really helped.

What finally worked was giving into my depression. I would come back from work, listen to sad songs, cry like a child, pray, and drink until I passed out. Within a few days, I would wake up without pit in my stomach. Hangover was another story. Within a couple of weeks, I was not depressed. Depression turned into anxiety. And anxiety was a lot easier to deal with than depression.

Once depression was mostly gone, then I was able to use CBT methods to deal with my anxiety.

It is really hard for people who never experienced depression to understand what it feels like. It is worse than hell. I am sorry you are going through it. Just take one day at a time.

throwawayboise · 3 years ago
I don't know if I've ever been clinically depressed. I've never been diagnosed, but I've never seen a therapist or talked to a doctor about it either.

I have defintely had periods of unexplained very low motivation and lethargy. I've done the "listen to music and get really drunk alone" thing a few times. It did seem to help, though I didn't do it with that intent. It kind of slapped me in the face with a "you are pathetic, get over it" message that really sunk in. It has been a few years since I have done that.

I also started exercising (weightlifting) about 2 years ago, which is something I never did before. I have tried other exercising (biking, running, swimming, etc.) but none of it ever stuck. Weightlifting did for some reason. Barbells, not machines. Squat, bench press, deadlift. Read or watch some videos from Mark Rippetoe "Starting Strength." I can't say I enjoy doing it, but for some reason I have kept at it and I do like the effect on my body. I'm 55 and have the best muscle tone I've ever had in my life.

I also take a regular multivitamin every day, along with moderate additional C, D, and Zinc. I don't get headaches anymore and I hardly ever even get a cold. I don't eat fast food or drink soda, I eat mostly chicken, steak, and salad and drink water, coffee, or tea.

afr0ck · 3 years ago
I had been, not long ago, through a crippling depression that I fought by myself. Initially, it crippled me to the point of not being able to get up from bed and start my day (I spent the whole weekend on bed, feeling terribly sad, regretful and helpless. I only get up for biological needs).

After 5 or 6 months of suffering, I decided, at some certain point, that I need to do something about it and that I need to get over it and not waste my life. I started small, step by step, waking up, taking shower, going out for a walk, etc. I used to WFH, but I reversed the habit and started to go to work place everyday.

Then, I got a gym membership and started exercising almost everyday (after so many years of physical inactivity. I am 25 BTW). I started cooking and eating healthy. I take multivitamins everyday with an additional dose of Vitamine D and Magnesium. I eat only vegetables (lots of them), rice, chicken and fish and sometimes beef steaks. I also take fruits everyday (usually Oranges, Bananas and Apples). I also drink Coffee (one cup in the morning and sometimes another in the evening) and Tea with Ginger.

I feel much better. Now, I have a routine, I am more active and I get some work done. However, I still suffer from a slight lack of motivation and happiness. I still feel a bit unhappy and I am not as motivated as I was before the whole depression thing hit me. I don't know why and I have no idea how to solve this part to become the super motivated, super focused and super productive person I used to be.