Disk space is cheap. It's most likely not worth the 20% compression to lose your original images (and possibly lose metadata as well--it's quite hard to robustly retain all vendor-specific MakerNotes, for example).
Also if you decide to forgo the reversibility you can get a bit more out of it as JXL is actually a superset of JPEG, so it can read the JPEG stream and convert it to JXL without complete recompression - it will just use more efficient structure of JXL and much more efficient (ANS vs. Huffman) entropy encoding. The additional savings compared to the reversible mode aren't big however.
My impression is that this is more or less how ISO standards are supposed to work. Personally, I don't want to work in such an environment.
The process has its issues and could cause problems, but in practice I don't remember anyone reporting issues.