The issue with these studies, according to what I've heard, is that they use the wrong type of aspirin - they use enteric-coated aspirin, which doesn't work the same way. Instead, if you take pure aspirin (you can only find it for veterinarian use) together with vitamin C and/or DGL (Deglycyrrhizinated Licorice), then you protect your stomach from aspirin, and it acts as it's supposed to act. Georgi Dinkov of Ray Peat's fame told me once that another trick is to take aspirin with gelatin, which also coats and protects your stomach lining. I discussed different novel aspirin formulation such as the disappeared now Vazalore. I still think the easiest way is to take Aspirin C by Bayer in Europe and breat it into 4 pieces, because the asprin dose is pretty high otherwise, which is good if you have an acute problem, but it's a bit too much for a daily use.
Readit Newsnikolay commented on Aspirin Confers No Long-Term Heart Benefits in Older Adults medscape.com/viewarticle/... · Posted by u/wjb3
nikolay commented on Paracetamol disrupts early embryogenesis by cell cycle inhibition academic.oup.com/humrep/a... · Posted by u/XzetaU8
People do that because they haven't been "educated" (even superficially) about what fever really is, which is your body working hard to fight of the infection. And messing with it is counterproductive.
They also do it with their kids because they want to help them. Also, some people have a lot on their plate, calling them lazy is not right thing to do. I have health insurance that covers me when my kids are sick (not in the US), so I can take care of them "properly ". This doesn't make me more responsible and someone else that works two jobs and can't afford to have sick kids lazy.
Also, I don't lower fever, even with my kids unless it prevents them from sleeping. But overstated is relative, it's happened to the kid next door from me. You don't want to be careless with infants.
They are lazy if they don’t educate themselves about what they are doing and what they are giving their children. Don’t get offended. I’ve never done anything health-related to my kids without doing thorough research. I’ve witnessed four major medical mistakes made right in front of me in Orange County, California, in some of the best medical facilities and by the best pediatricians in the area! That’s why I don’t blindly trust anyone, whether it’s a doctor or not. I use critical thinking and always look for alternative advice. Doctors often find me a nuisance, but that’s okay with me. Just try asking a doctor when they prescribe Tylenol for a fever: “Why should I try lowering their fever?” or “Why should I give them Tylenol exactly?” The hepatotoxicity of acetaminophen occurs when the production of the toxic metabolite NAPQI exceeds the liver’s glutathione detoxification capacity, which can happen quite frequently during infections! So, then ask your doctor: “Doesn’t it make sense to give them NAC with Tylenol as well, just in case?” They won’t know what to say, trust me!
nikolay commented on Paracetamol disrupts early embryogenesis by cell cycle inhibition academic.oup.com/humrep/a... · Posted by u/XzetaU8
> risks of febrile seizures are overstated and if you're a responsible parent, not a lazy one, you can see if things are going South
Not always. Blaming “lazy” and irresponsible parents is disgusting.
But it's the truth. Something that has just a 2% incidence should not dictate 98% of the treatments. Compromising the innate immunity of the 98% is more disgusting!
nikolay commented on Paracetamol disrupts early embryogenesis by cell cycle inhibition academic.oup.com/humrep/a... · Posted by u/XzetaU8
I have not found any study published after 2020 (the year when the French minister made the statement) that advises against ibuprofen for COVID-19. But I'm not a doctor, so I'd be interested to know your source.
Studies showed negative efficacy. At best, no difference. [0]
nikolay commented on Paracetamol disrupts early embryogenesis by cell cycle inhibition academic.oup.com/humrep/a... · Posted by u/XzetaU8
nikolay commented on Paracetamol disrupts early embryogenesis by cell cycle inhibition academic.oup.com/humrep/a... · Posted by u/XzetaU8
I never took Tylenol/Paracetamol/acetaminophen, or anything containing it or given it to my children. We never reduce fever below 39.5/103.1 either - risks of febrile seizures are overstated and if you're a responsible parent, not a lazy one, you can see if things are going South, but there are other traditional means to lower fever. People are just too spoiled nowadays!
I tested positive with COVID-19 on Tuesday and had a pretty high fever (103) with a terrible headache, but I didn't take ibuprofen. First, because it could lower my fever, second, because its anti-inflammatory effect would compromise my immune system response to the pathogen. Most people I know immediately try to lower their fever to reduce their discomfort and would immediately take it for headaches, too.
What I mean is that the Hayflick limit is a concept from the laboratory; it applies to cells that divide quickly, like skin cells, but it has limited practical use for strategies aimed at extending an animal's lifespan, because as the animal or human ages, it will lose neurons and muscle strength (including heart muscle).
In other words, 100% of humans relying only or mainly on telomere repair will be faced with Alzheimer’s, Parkinson’s, and/or ALS, as well as cardiovascular diseases, before they reach 100 years old.
I thought we're past the times when we thought cartilage, neurons, and other tissues cannot regenerate. Didn't we, for example, find that BDNF activators can trigger neurogenesis?
No worries!
Not all cells divide (neurons and some muscle cells don't divide); some cells divide very slowly. And in some cases telomeres may be repaired but this increases the risk of cancer [0]
https://biologyinsights.com/what-is-telomere-repair-and-is-i...
I'm fully aware of cancer risks with substances such as astalagus extract, but maybe telomerase activators can be combined with anti-cancer strategies such as fasting, etc.
> "human cells don't divine indefinitely!"
I apologize about the typo, but it's true that cells don't divine without a (Hayflick) limit due to telomere shortening. Excessive autophagy is detrimental. The best strategy is to prevent cells from becoming senescent.
I would appreciate any pointers to a scientific article that describes this.
[0]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6336700/
[1]: https://www.sciencealert.com/new-study-reveals-more-about-ho...