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mrosett commented on Iowa City made its buses free. Traffic cleared, and so did the air   nytimes.com/2025/11/18/cl... · Posted by u/bookofjoe
mrosett · a month ago
I'm calling BS on this one.

The claimed increase in ridership is modest (18%) off a low baseline (0 service on weekends) and occurred over a long time period (pre-pandemic to today.) They also expanded service during that period, which probably fully explains the increase in ridership. Certainly the reduction in fare ($1-->0) is nice for some people, but it's hard to imagine that it is actually decisive for a large portion of trips.

The estimates of traffic reduction and CO2 reduction just quote the city's numbers without establishing that "traffic cleared, and so did the air."

Key paragraphs:

> In 2021, the city starting [sic] running more buses, streamlining routes and seriously considering waiving the $1 fares. In 2023, the City Council voted to pay for a two-year fare-free pilot with Covid-19 relief funds.

...

> Ridership eventually grew to 118 percent of prepandemic levels, compared to the average nationally transit ridership-recovery levels of 85 percent.

mrosett commented on UPS plane crashes near Louisville airport   avherald.com/h?article=52... · Posted by u/jnsaff2
lostlogin · 2 months ago
Do we need that? MH370 may have benefitted, but it’s hardly a common problem.
mrosett · 2 months ago
The belief is that MH370 was depressurized which would have killed the passengers. A better example is Germanwings 9525 where the locked door allowed the first officer to crash the plane.
mrosett commented on When private practices merge with hospital systems, costs go up   insights.som.yale.edu/ins... · Posted by u/hhs
roughly · 3 months ago
> trying to help a person but being greedy while doing it.

The doctors are trying to help people, the execs are being greedy while doing it. Leadership doesn’t get the benefit of the doubt at this point.

mrosett · 3 months ago
Plenty of docs making the better part of a million dollars.
mrosett commented on When private practices merge with hospital systems, costs go up   insights.som.yale.edu/ins... · Posted by u/hhs
ikiris · 3 months ago
This issue is much more linked than you think, because its a strategy to upcode to have external practice groups.
mrosett · 3 months ago
Your assertion runs counter to the original article, which says that acquiring external practice groups raises prices.
mrosett commented on When private practices merge with hospital systems, costs go up   insights.som.yale.edu/ins... · Posted by u/hhs
ceejayoz · 3 months ago
Ah, but deaths…

Go up too. https://hms.harvard.edu/news/deaths-rose-emergency-rooms-aft...

Part of the problem of modern society is that statistical murder of thousands is treated as less of a crime than a normal murder of one person.

mrosett · 3 months ago
These are two distinct issues.

The study you linked concerns whether the hospital is owned by a nonprofit or by a private equity group.

The question in this study is whether physicians work for their own practice or for the hospital directly, regardless of the ownership of the hospital.

mrosett commented on Jeff Bezos says AI is in a bubble but society will get 'gigantic' benefits   cnbc.com/2025/10/03/jeff-... · Posted by u/belter
harmmonica · 3 months ago
Do I have this right that there have been no or at least very few pure AI IPO's during this cycle (I can't actually think of a single one)? So it's dissimilar to dotcom in that regard because during that time countless dotcoms went public with sky-high valuations and then failed. A bunch of reputable companies also went or were already public during that time and those saw huge valuation drops so that's more analogous to what could happen in the public market (NVDA, for instance, could pull a Cisco and drop "catastrophically," but survive just fine).

That would cause a lot of pain for those shareholders, but would that be somewhat contained given the public "AI" companies for the most part have strong businesses outside of AI? Or are these market caps at this point so large for some of these AI public companies that anything that happens to them will cause some kind of contagion? And then the follow up is if the private AI companies collapse en masse is that market now also so big that it would cause contagion beyond venture capital and their investors (fully aware that pensions and the such are material investors in VC funds, but they're diversified so even though they'd see those losses maybe the broader market would keep them from taking major hits).

Not giving an opinion here, though my knee jerk is to think we're due for a massive drop, but I've literally been saying that for so long that I'm starting to (stupidly) think this time is different (which typically is when all hell breaks loose of course).

mrosett · 3 months ago
IPOs aren't what they once were. The burden of being a public company has increased (SOX and related public company costs are $5-10M/year), so companies are far more likely to stay private. That has created a positive feedback cycle as the private funding ecosystem has become increasingly robust, which is why you see so many $100B+ private companies.

Also keep in mind that the biggest companies during that bubble had peak market caps of ~500B and then lost ~90%, so 400-500B in losses each and total internet related losses of a couple trillion. If NVDA lost 90%, it would be down 4 trillion dollars, or twice that total just by itself.

AI company valuations collapsing would have meaningful impacts on the broader market. Big pension/mutual funds are important sources of capital across every sector, and if they're taking big losses on NVDA, GOOG, and a portfolio of privates, it will have a chilling effect on their other activity.

mrosett commented on 'Universal cancer vaccine' trains the immune system to kill any tumor   newatlas.com/cancer/unive... · Posted by u/01-_-
CoastalCoder · 5 months ago
Out of curiosity, are there examples of drug development that did poorly in animal models, but then did much better in human trials?

I'm guessing this is rarely tested since animal modeling is usually a gating factor for human testing?

mrosett · 5 months ago
Checkpoint inhibitors (which are the primary driver of improved cancer treatment over the last 15 years and generate > $50B/year in sales) generally don't look very good preclinically. Even their clinical data can be hard to interpret prior to a large scale trial, which led to them almost being shelved.

The catch here is that only two targets (PD(L)-1 and CTLA-4) turned out to work well in humans. All of the other immunotherapies that looked mediocre preclinically turned out to also be mediocre or entirely ineffective in humans.

mrosett commented on Nearly 20% of cancer drugs defective in four African nations   dw.com/en/nearly-20-of-ca... · Posted by u/woldemariam
SoftTalker · 6 months ago
They will both die. Cancer treatment is largely useless (this is an editorial statement) Survival statistics are largely dependent on early detection. Detect the cancer early, you live longer after treatment.
mrosett · 6 months ago
This is an oft-refuted trope that does harm to patients. Numerous randomized phase 3 studies show meaningful survival advantages for modern treatments.
mrosett commented on The Tech Job Meltdown   professoraxelrod.com/p/th... · Posted by u/mooreds
jleyank · 6 months ago
I would think there’s a similar impact on biotech/pharma which relies on research finding candidates to take into development. These companies can burn a whole lotta money and I think their job market has been brittle over the last year as well. These are ms/phd/md kinds of jobs for the most part. Sudden upturns in laoyff or surrendering companies would confirm the article.
mrosett · 6 months ago
This isn’t really an issue in biotech since companies don’t have any revenue until late in their lives. Ie if I’m doing discovery work for a drug candidate today, it won’t generate revenue for 7+ years. So when if I have to amortize those costs over 5 years, that process will be complete by the time the project generates revenue.

I can’t speak to the pharma side as much, but since the 174 issue is most painful for companies with liquidity issues, I doubt it has a huge impact on them.

mrosett commented on Sprint, T-Mobile Merger Killed Wireless Price Competition in U.S.   techdirt.com/2024/05/16/r... · Posted by u/rntn
mrosett · 2 years ago
Does this article actually provide evidence for the headline claim?

u/mrosett

KarmaCake day2691August 13, 2018View Original