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joefigura commented on Grifters, believers, grinders, and coasters   seangoedecke.com/programm... · Posted by u/rbanffy
encoderer · a year ago
People are multi-dimensional.

I’m 42 and I’ve been all of these things at different times.

joefigura · a year ago
The author makes this point.

"These aren’t immutable aspects of your personality. They’re more categories for how you approach the job of software engineering - you’ll move around between quadrants as you change your approach to work, for all the usual reasons."

joefigura commented on Oregon decriminalized hard drugs – early results aren’t encouraging   theatlantic.com/politics/... · Posted by u/slapshot
gspencley · 2 years ago
It's working just fine.

I guess if you want drug use to go down, or to reduce deaths etc. if those specific metrics are you goals, and nothing else matters, that's one thing. Maybe it is not "working" by those standards.

But I don't want a government having any opinion on what people put into their own bodies. It is a health/medical issue and, in a broader context, a liberty issue. It is not a legal issue in my opinion. Regardless of drug use statistics, no one belongs in jail or with a criminal record for no reason other than possessing and/or consuming an intoxicant. I don't even care if drug use goes up with decrminalization or legalization. In my opinion it is simply outside of the proper moral scope of a government to concern itself with such matters. Feel free to disagree. This is my personal political view.

joefigura · 2 years ago
A person who becomes addicted to opiods, methamphetamine, or other "hard" drugs will with some probability require medical treatment, and and some people who uses those drugs will cause other costs to society. I don't know what those percentages are, but for opiods it's definitely not negligible. Many people begin using opiods and become addicted without intending to, and later need medical assistance. So there is a public interest in how much these substances are used, and it's legitimate for government to regulate them.

In other words, there's a tradeoff between the autonomy to do things to your body and the real costs that drug addiction imposes on others.

joefigura commented on Promising Cancer Drug - AOH1996 Cancer Drug Paper   cell.com/cell-chemical-bi... · Posted by u/joefigura
joefigura · 2 years ago
This is the paper on AOH1996 which a flagged front-page AI-generated story was based on. The title of the paper is "Small molecule targeting of transcription-replication conflict for selective chemotherapy," but that was too long for HN, so I substituted a title
joefigura commented on Cancer pill AOH1996 shows promise in annihilating all solid tumours   innovationorigins.com/en/... · Posted by u/netfortius
gardenfelder · 2 years ago
joefigura · 2 years ago
That is not the paper mentioned in the press release, that's a different paper on the drug published in 2018 by the same group. The current paper is here:

https://www.cell.com/cell-chemical-biology/pdfExtended/S2451...

joefigura commented on Cancer pill AOH1996 shows promise in annihilating all solid tumours   innovationorigins.com/en/... · Posted by u/netfortius
gwill · 2 years ago
"Percentage of the article that is generated by AI: 63%"

I appreciate the transparency, but just raises questions for me. What parts were generated by AI? What edits were made to correct the AI? Why did they feel AI was necessary?

joefigura · 2 years ago
That article should be ignored and people ought to read the PR that the research group put out.

https://www.prnewswire.com/news-releases/city-of-hope-scient...

Edit: Or better yet, the paper https://www.cell.com/cell-chemical-biology/fulltext/S2451-94...

joefigura commented on Cancer pill AOH1996 shows promise in annihilating all solid tumours   innovationorigins.com/en/... · Posted by u/netfortius
mebazaa · 2 years ago
this is super AI-generated. paradoxically, the PR release might be a better link: https://www.prnewswire.com/news-releases/city-of-hope-scient...
joefigura · 2 years ago
Agreed, the author on the linked article is listed as an AI, and the article is just an AI mangling of the PR release. The PR release is directly from the group and the link ought to be changed.

Edit - Here is the FDA record page for the relevant clinical trial: https://classic.clinicaltrials.gov/ct2/show/NCT05227326?titl...

The press release says they've published a paper today, but doesn't link to it or say where it was published. So if anyone has journal access and can see or share the paper let us know.

Edit2 - The paper is here: https://www.cell.com/cell-chemical-biology/pdfExtended/S2451...

joefigura commented on A room-temperature superconductor? New developments   science.org/content/blog-... · Posted by u/nneonneo
deeg · 2 years ago
I'm astounded that the MSM seems to be ignoring this ATM. I did a Google news search on LK-99 and saw nothing from major publications. A search on the NYTimes returned an article from 1974.
joefigura · 2 years ago
Well, half the comments are making fun of the spotty quality of the evidence and it's been barely a week since the paper was published. I think it's reasonable to wait for at least a pre-print of a successful replication. I don't think it's fair to say the MSM is ignoring it, the possible discovery literally just happened and some combination of low awareness and caution with the evidence means they haven't covered it yet.

u/joefigura

KarmaCake day476February 15, 2021
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