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jinder commented on Low serotonin levels might explain some Long Covid symptoms, study proposes   science.org/content/artic... · Posted by u/rbanffy
avisser · 2 years ago
Perhaps my favorite science experiment, next to dual-slit, https://radiolab.org/podcast/197242-gut-feelings

They cut the vagus nerves of rats and see behavior change.

Which makes sense to me - when "brains" first evolved, the connection to the stomach would've been the prime connection.

jinder · 2 years ago
Not just that. In mice, SSRIs stop having any anti-depressant effects if the vagus nerve is severed: https://www.nature.com/articles/s41598-019-50807-8

So they also seem to be effective via the enteric nervous system!

jinder commented on Low serotonin levels might explain some Long Covid symptoms, study proposes   science.org/content/artic... · Posted by u/rbanffy
RohMin · 2 years ago
While most of the body’s serotonin is indeed in the gut, the serotonin that impacts our mood, sleep, and other cognitive functions is exclusively produced and used in the brain.
jinder · 2 years ago
While the serotonin used in your gut doesn’t directly impact the brain, it does impact the enteric nervous system which communicates via the vagus nerve to your brain. So I don’t think it’s correct to say this doesn’t (or couldn’t) impact your mood (and indeed murine experiments demonstrate it does).
jinder commented on New study will examine irritable bowel syndrome as long Covid symptom   healthsciences.arizona.ed... · Posted by u/elorant
willcipriano · 2 years ago
IBS is a illness that many people legitimately suffer, but also many hypochondriacs claim to have without evidence.

The symptom profile of long covid is very close to lyme disease, another disease people actually get but also many more people claim to have without evidence.

I'd like to see the overlap between long covid sufferers, IBS, lyme disease, people with a gluten allergy, PCOS etc and the level of evidence that they actually have those diseases.

jinder · 2 years ago
Or perhaps there are significant links demonstrated in murine models of the multi-directional relationship of the gut-brain-immune axis, and that traditional models of disease are not sufficient to elucidate this?
jinder commented on Common infections can spark psychiatric illnesses in children   economist.com/science-and... · Posted by u/hampelm
whimsicalism · 2 years ago
Would recommend CBT.

e: I'm downvoted but this is one of the only treatments with best-in-class evidence for its effectiveness in treating long covid as well as CFS and IBS. The body is a complex organism.

jinder · 2 years ago
Where is the best-in-class evidence that CBT is effective at treating long covid and chronic fatigue syndrome?
jinder commented on Growing scientific interest in vagus nerve stimulation   theguardian.com/society/2... · Posted by u/acallaghan
InSteady · 2 years ago
That's interesting about famotidine. This is also a treatment for MCAS, which is probably under-diagnosed because it's kind of obscure and the diagnostic criteria kind of suck currently. It can reduce stomach acid, so my doctor and I decided against using it as the first option in treatment, but may reconsider even though the alternative seems to be working. Thanks for the link and explanation.

Can you share any relevant resources or ideas you've gotten on reducing the opportunists and increasing butyrate production? I've coaxed and cajoled my MMC and other digestive processes back into shape, or so it seems, but am struggling on the microbiome angle. It's tricky because the list of foods that trigger symptoms is insanely long, so it's hard to get creative and experimental as far as that goes.

jinder · 2 years ago
Some people really do have mast cell issues, but everyone and their dog thinks they have MCAS these days and it's questionable in my opinion. Often a diagnosis will be based on whether any of the MCAS-drugs work (rather than testing which is very problematic for MCAS). But as you see in the linked paper famotidine was effective in mice genetically engineered without mast cells, so at least in that instance it's not a mast cell issue.

The tricky thing with increasing butyrate production is that everyone's gut dysbiosis is different - and therefore, a prebiotic that works for one person may make someone else's condition worse. For example, I have big blooms in my Prevotella Copri population which would consume Inulin and make my butyrate production worse - but in people without a Prevotella Copri overgrowth, Inulin would improve their butyrate production.

I would look into 16S microbiome testing (I use Biomesight) and use that as a guide, as well as slowly trialing interventions and monitoring symptoms. None of this is perfect and you kinda have to be on the bleeding edge of science/alternative medicine to figure things out.

jinder commented on Growing scientific interest in vagus nerve stimulation   theguardian.com/society/2... · Posted by u/acallaghan
theshrike79 · 2 years ago
I have acid reflux and possibly a mild hiatal hernia. When it triggers in Just The Right Way, I also get severe panic attack symptoms.

When I started investigating it (my coping mechanism during panic attacks) I discovered that the vagus nerve travels next to the esophagus through the diaphragm.

So my complete layman explanation was that the stomach pushes through the diaphragm during a hiatal hernia -> it rubs against the vagus nerve -> panic attack symptoms.

I might need to add the study of vagus nerve to "why haven't we studied this about the human body more" -list along with gut bacteria composition.

jinder · 2 years ago
Famotidine an old school H2 antihistamine used for acid reflux (pre PPIs), was found to have an additional mechanism of action via activation of the vagus nerve to inhibit pro-inflammatory cytokines in covid (via alpha 7 nicotinic acetylcholine receptor (α7nAChR) signal transduction - https://molmed.biomedcentral.com/articles/10.1186/s10020-022...).

It has also been used quite extensively to combat post-covid neuropsychiatric symptoms.

I think the link here is that increased LPS/endotoxin production by your microbiota can induce acid reflux, cause neuroinflammation and psychiatric symptoms. Low acid production itself can result in a more inflammatory microbiome further exacerbating the problem. Long term fix would be working on the migrating motor complex, improve motility/gastric emptying and rebalance the microbiome by reducing gram-negative bacteria/pathobionts and increasing butyrate production via selective feeding. [I'm not a doctor, this is just the direction I've been working on things myself]

jinder commented on London Then and Now: Aerial Shots Show City Grow over Past Two Decades   londonist.com/london/art-... · Posted by u/susam
SilverBirch · 2 years ago
It's fascinating how boom and bust this is. You look at the City, or at King's Cross and there's just been a total transformation. Then you look at Nine Elms or Highbury and really very little has changed.

You've got Wembley - massively built up, loads of carparks gone and building in it's place. Then you've got the Millenium Dome, one big car park in 2007, one big car park in 2023.

jinder · 2 years ago
What bust are you referring to? As far as I can tell there's still considerable development going on all around London.
jinder commented on Mindfulness-based programs show promise in reducing psychological distress   nature.com/articles/s4422... · Posted by u/_kyran
NoZebra120vClip · 2 years ago
While I'm not a Buddhist, I'm fairly certain that the Buddha is the last guy to want to be the center of anyone's attention. Weird.

Buddhist contemplative traditions predate Christianity, and arose in distinct geographic locations, so nobody's de-Buddhizing anything here. Authentic understanding of the practices doesn't need to be a sectarian monopoly.

The uniquely indifferent, secular practice of "cafeteria Mindfulness" is the only novelty. It's exactly the M.O. of science: dissect a living thing and run tests until you think you know what substance makes it tick, then you isolate it, independently synthesize that substance, patent it, mass produce it, and then you wonder why you've got such shitty results in practice, and then you cover that up along with the adverse side effects, and charge the insurance companies triple profits.

jinder · 2 years ago
How do Christian contemplative traditions predate Buddhism if Buddhism arose in the 5th century BCE?
jinder commented on NHS waiting lists in England hitting new high of 7.2M people   itv.com/news/2022-12-08/n... · Posted by u/open-source-ux
benjaminwootton · 3 years ago
Many of us predicted that the Covid restrictions would kill more people than they would save.

Excess deaths have been high all year and this is likely to remain the case for the next decade. We’ve obliterated the health service and also damaged the economic engine to pay to fix the problem.

(And I’m still downvoted. Open your eyes people, it’s basically Stockholm syndrome at this point!)

jinder · 3 years ago
How have you determined that the excess deaths are due to "covid restrictions" and not for example, long term sequelae of covid itself or other factors?
jinder commented on Is it time to retire the .gb top level domain?   cddo.blog.gov.uk/2022/11/... · Posted by u/robin_reala
actionfromafar · 3 years ago
If you want to get really weird, look into City of London and some of the Channel Islands. UK very much retains living heritage of the medieval.
jinder · 3 years ago
I think the independent status of the City of London is grossly exaggerated and not really comparable with the Channel Islands.

u/jinder

KarmaCake day193June 11, 2013
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