or Anthropic models on AWS, etc.

It's mostly the kidneys that get damaged, not so much the liver. It also has a massive amount of benign or merely annoying side effects. Lithium might even be the drug with the largest overall amount of side effects. It's certainly a weird one.

High-dose lithium is extremely hard on your kidneys and may well lead to kidney failure in a decade or so. Medium-dose lithium is a lot more gentle but still requires monitoring. Many people can go down in dose after initial treatment, and good psych prescribers will attempt to do this after a while. (Or patients will request it, after the other side effects of lithium become noticable after the bipolar has settled down.) Low-dose lithium is much harder to study and may well be pretty safe. May.

It is not quite true that people have no idea how it cures bipolar disorder. It's definitely affecting the ion channels (sodium, potassium, etc), just like many other anticonvulsant drugs also used for treating bipolar. So the mechanism for action is not totally insane and unique. Now, why the ion channels are the place to go for certain people, that's an open question....

That's quite a stretch. Lithium does not cure bipolar disorder nor is it effective in many afflicted. Also, Lithium is not the only medication for Bipolar Disorder, there are a double-digit number of alternative options.

Also, to my knowledge, we are not entirely sure why most, if not all, of the psychiatric drugs work. Plenty of hypotheses though.

You could spray insecticides and kill some percentage while damaging the books further.

Or you put them in a sealed environment with no oxygen, killing every single one of these beetles.

I'm not sure that the more lethal option is "tame".

They gave the mice 15mg, which is about a low-medium dose for a human. But humans weigh about 2000 times what mice do, so the effects were observed at about 2k times a reasonable dose.

1) Those mice must have been completely out of it. 2) This probably isn’t helpful to humans unless given under sedation. Or maybe that extreme a dose is equivalent to sedation, I’m not sure anyone has taken 30 _grams_ of psilocybin to tell us?

It's just the fact that renewables aren't enough (since it's not always windy or sunny) and storage just isn't cheap or plentiful enough. They're great in many ways, but they alone won't provide enough power and stability.

So you're left with water power (which is only applicable in few areas and they destroy the nature), coal/oil/gas (which are much worse for the environment) and nuclear energy.

Nuclear might not solve everything itself either, but it's definitely part of the solution.