I tune in all fourths as well. For me it has made a huge difference since I made the jump some years ago. Putting voicings, patterns, etc., into muscular memory is faster and a lot less work. For my purposes, it makes the instrument more intuitive with a better ear-hand connection. Even very advanced players trip on the G-B strings oddity (with things like playing a fast, angular melody on different string sets, without preparation, for example).