(April 1, 2024)
Readit Newsphnofive commented on · Posted by u/aadillpickle
> A tantalizing clue stemmed from men who have two X chromosomes and one Y chromosome, a rare condition called Klinefelter syndrome. These men run a much higher risk of suffering from autoimmune diseases, suggesting that the number of X chromosomes plays an important role.
Interesting. And apparently this is pretty common. Less than 1 in 1000 male births.
Speaking of, here's a study showing a reduction (sort of) in autoimmunity in such persons following a course of TRT:
phnofive commented on Evidence and Orthodontics: Does Your Child Really Need Braces? undark.org/2020/07/20/doe... · Posted by u/bookofjoe
(2020)
Submitted once before, but not discussed at the time.
It more or less complies with Betteridge's law of headlines, but since publication, the article was amended:
> Editor’s Note: The original version of this article failed to disclose that some of the quoted critics of orthodontics have financial ties to alternative, direct-to-consumer therapies. While the criticisms raised by these experts pre-date these financial ties by decades, and Undark’s reporting — both prior to and after publication — supports the story’s premise that there is disagreement within the discipline over many of the purported medical benefits of traditional orthodontics, these relationships should have been acknowledged in the original article. They have now been added, along with a response from the individual experts involved.
phnofive commented on Ozempic Is Making People Buy Less Food, Walmart Says bloomberg.com/news/articl... · Posted by u/cachecrab
https://archive.is/O0zr5
Anyone here taking Ozempic? Care to share your experience?
Taking compounded tirzepatide ($6000/yr for 15 mg/wk) and lost ~120 lbs. Ironically, sugar tastes a lot stronger, and food generally tastes better, but I don't want as much. Haven't seen any other changes or improvements.
phnofive commented on Show HN: Rot - Offline secrets management github.com/candiddev/rot... · Posted by u/candiddevmike
Huh, nitializing the submodule with GH requires key-based auth. Learned a lot just setting it up locally.
phnofive commented on Why you can't divide by zero garrit.xyz/posts/2023-11-... · Posted by u/sharjeelsayed
The problem with this explanation is that I should perfectly well be able to divide my jellybeans into 0.5 or -1 groups, though those also make no real sense in this example.
Stretching the metaphor, but your jellybeans were in a group to start with, so halving it makes sense.
Changing the sign is harder, but let's say your group of jellybeans was actually a loan, and you borrowed from two people... beans / -2
She already was comfy. I'm 51 and I've never actually even heard of a job where you ONLY had to know a specific dialect of SQL. Also, you would think that mere intellectual curiosity would have taken her at least somewhat "abroad" in the knowledge sense, but I see no evidence of that, which means she was basically a corporate mercenary for 20 years who phoned it in. (Note: I've mostly worked for startups, so my standards and expectations about "job interestingness" and "job expectations" and "necessary intrinsic motivation" are possibly entirely different.)
She needs to find a giant corporation where she can live out her pre-retirement days in Storage Room B, only writing very specific SQL queries for Oracle, IMHO.
Data migration is not that hard, so the fact that she's balking at even step 1 says a lot to me.
> She needs to find a giant corporation where she can live out her pre-retirement days in Storage Room B, only writing very specific SQL queries for Oracle, IMHO.
Cool, how should she get started?
phnofive commented on Ask HN: Switching from Software Engineer to Data Engineer Because of Leetcode · Posted by u/AdityaSanthosh
Kind of. I just switched from senior software engineer to junior data engineer. I did it because this position is work from home and honestly all JavaScript positions at this point are junior positions.
90% of JavaScript jobs now are really React positions or Angular plus Java positions. If you need React/Angular and spend all your time over-engineering how to put text on screen and at this point cannot figure out Node you are a supremely overpaid junior. After working with overpaid juniors at the last job and getting laid off from it, it feels like a broken house of cards ready to fold at any time.
So, after refusing to go back to work in that line of work for 5 months a recruiter for this data science job found me and I super easily qualified. There was no leet code nonsense. This current project uses a low code enterprise suite for data science and service delivery and starts with up to 6 weeks training to certify in the platform.
I'm looking for a similar change - if you don't mind my asking, are they still hiring?
phnofive commented on Wegovy's heart benefits due to more than weight loss, Novo says reuters.com/business/heal... · Posted by u/JeremyNT
Reads line an ad and also stinks like damage control after what Reuters posted last month regarding GI track issues. [1]
[1] https://www.reuters.com/business/healthcare-pharmaceuticals/...
Tract*
I honestly don't know what to say about someone who can't recognize their own intestinal blockage. Perhaps ask patients to keep a BM journal and flag anomolies?