Readit News logoReadit News
normie3000 commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
Fogest · 16 hours ago
I only had an issue because I was taking an iron supplement at the same time which also can further cause constipation. I stopped taking that and it resolved my constipation issues.

I'm not too sure what you're referring to with a "write off day". I am on the highest dose currently and don't have this issue. I maybe get some sleepiness the day after taking it but I can still do things. However that effect has also subsided a lot after taking it for long over.

Every medication will have pros and cons. I'm having huge success on the medication and the slight issues I have are a worthy tradeoff personally.

normie3000 · 16 hours ago
> I'm not too sure what you're referring to with a "write off day".

Some people aren't comfortable leaving the house when their rear is flowing like Niagara Falls.

normie3000 commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
r00fus · 16 hours ago
If you don't have a regime that supports the medication, you could suffer some real problems. Drinking a LOT of water is mandatory. As well as eating lots of fiber - like good p-fruits (plum/pear/peach/etc) or benefiber/laxative.

I've had no problems following the advice of my weight loss program and r/Zepbound etc.

normie3000 · 16 hours ago
Pineapple?
normie3000 commented on Stories from 25 Years of Software Development   susam.net/twenty-five-yea... · Posted by u/vinhnx
alexjplant · 4 days ago
I've worked at a place or three where development environment setup took the better part of two days. Sometimes it was due to shitty proprietary software that nobody had bothered to automate the installation and configuration of. Other times it was due to an accumulation of crufty half-abandoned OSS projects with shell script glue liberally applied to hold it all together. In virtually all cases these environments would break randomly every few months and lead to unnecessary dev downtime.

One place I worked decided that it'd be easier to build an AMI and provision quasi-ephemeral EC2 instances to developers instead of putting the time in to pare down the landfill of dev dependencies they had. This whole process was, of course, orchestrated by a custom CLI that would itself randomly break in odd ways.

Fun times.

normie3000 · 4 days ago
> I've worked at a place or three where development environment setup took the better part of two days.

I feel like this is a real barrier to getting effective contributions from outside of existing team members. Some colleagues seem to see this as an advantage.

normie3000 commented on Coding agents have replaced every framework I used   blog.alaindichiappari.dev... · Posted by u/alainrk
milowata · 4 days ago
I had this moment recently with implementing facebook oauth. I don’t need to spend mental cycles figuring that out, doing the back and forth with their API, pulling my hair out at their docs, etc. I just want it to work and build my app. AI just did that part for me and could move on.
normie3000 · 4 days ago
Integrating auth code is probably a good example of code you want to understand, rather than just seeing that it appears to work.
normie3000 commented on Coding agents have replaced every framework I used   blog.alaindichiappari.dev... · Posted by u/alainrk
marginalia_nu · 4 days ago
I honestly think the stuff AI is really good at is the stuff around the programming that keeps you from the actual programming.

Take a tool like Gradle. Bigger pain in the ass using an actual cactus as a desk chair. It has a staggering rate of syntax and feature churn with every version upgrade, sprawling documentation that is clearly written by space aliens, every problem is completely ungoogleable as every single release does things differently and no advice stays valid for more than 25 minutes.

It's a comically torturous DevEx. You can literally spend days trying to get your code to compile again, and not a second of that time will be put toward anything productive. Sheer frustration. Just tears. Mad laughter. Rocking back and forth.

"Hey Claude, I've upgraded to this week's Gradle and now I'm getting this error I wasn't getting with last week's version, what could be going wrong?" makes all that go away in 10 minutes.

normie3000 · 4 days ago
I'm glad to hear the gradle experience hasn't changed in the decade since I started avoiding it.
normie3000 commented on A case study in PDF forensics: The Epstein PDFs   pdfa.org/a-case-study-in-... · Posted by u/DuffJohnson
mikkupikku · 7 days ago
> the employee might have found it easier to just flatten the pdf and apply a graphical filter to make the document appear like a scanned document

Is that remotely plausible? I can't imaging faking a scan being easier than just walking down the hall to the copier room.

normie3000 · 6 days ago
Working from home and no scanner in the house?
normie3000 commented on AI is killing B2B SaaS   nmn.gl/blog/ai-killing-b2... · Posted by u/namanyayg
noduerme · 6 days ago
My career occupies a weird middle ground where, for 20 years or so, I've catered to smaller businesses that need bespoke solutions (because the SaaS available doesn't conform well to their business logic), but don't have the scale or desire to build and maintain software in-house. Sometimes these are slapped together in a weekend, if that's all that's needed. But in most cases they still become ongoing improvement and maintenance projects for me.

This niche position has had some interesting ramifications for them and for me. They clearly incur a lot of technical debt once their business relies on bespoke software. On the other hand, they own the software and can get an immediate response or new feature or upgrade from me, limited only by my time. And in the end, this ends up saving them time and money. It gives me a permanent and unending flow of work. But if I die, they're pretty screwed.

One reason I don't vibe code things even now, even simple components that could easily be vibe coded, is that I remember and know where everything is, every function or line of code that might be causing issues, because I wrote it myself. I know right away where to look for a query that might be throwing errors after a database upgrade, for instance.

As a manager I assume you would probably not want to go down the road of hiring someone like that, but for companies of a certain size it's an acceptable compromise. However, I wouldn't want to hire someone like that myself unless they were extremely reliable and didn't rely on AI to write any of their code.

normie3000 · 6 days ago
This sounds great if you get on well with your clients. You must be an effective networker and at sales. How do you bill, and how do you price your services?
normie3000 commented on Aging muscle stem cells shift from rapid repair to long-term survival   phys.org/news/2026-01-spr... · Posted by u/bikenaga
vostok · 10 days ago
Do you know if running causes a person to have more or less heartbeats in a given time span? I'm not particularly medically knowledgeable and not sure.
normie3000 · 10 days ago
During the run their heart rate will be higher, but afterwards their resting rate might be lower.
normie3000 commented on Emoji Design Convergence Review: 2018-2026   blog.emojipedia.org/emoji... · Posted by u/surprisetalk
neogodless · 12 days ago
normie3000 · 12 days ago
This map doesn't seem accurate.
normie3000 commented on Emoji Design Convergence Review: 2018-2026   blog.emojipedia.org/emoji... · Posted by u/surprisetalk
Oarch · 12 days ago
The Toss emojis at the end of the article are surprisingly artful!
normie3000 · 12 days ago
Shame, I was hoping they'd introduced a "hand tossing" emoji.

u/normie3000

KarmaCake day763December 24, 2021View Original