ninala (u/ninala) - Readit News

ninala commented on At 17, Hannah Cairo solved a major math mystery quantamagazine.org/at-17-... · Posted by u/baruchel

assword · 7 months ago

> Jeez... what a damning indictment of today's Universities.

There’s a modern phenomenon I’ve been thinking about but have struggled to put a name to.

Everything just becomes so generalized, streamlined that it becomes impossible to operate outside of the pre defined “happy path”.

AI will make this increase 100x as taking humans out of the loop seems to accelerate this process.

ninala · 7 months ago

Perhaps the term "canalization" fits? Coined by C.H. Waddington, describing the process of forming a chreode in a homeorhetic system. But it doesn't really encompass the "everything becomes overly generalized" concept you mentioned. Rather, it's more about robustness against perturbation of a trajectory in a conceptual space. Christopher Alexander called them 'paths in configuration space'.

ninala commented on ‘With brain preservation, nobody has to die’ theguardian.com/science/2... · Posted by u/bookofjoe

glenstein · a year ago

>Our nervous system extends into our bodies. We feel emotions in our bodies. People with certain kinds of brain damage that prevents them from feeling emotions normally also experience trouble making rational decisions.

I think that may be true enough, but it doesn't have the upshot you seem to think it does.

It just means that what we need to sustain not just a brain itself but the totality of the environmental conditions on which it depends. No easy task for sure, but not something that presents an in-principle impossibility of preserving brains.

I think there's a major philosophical error here in thinking that the added logistics present this kind of in-principle impossibility.

Also, talking like this starts to play with anti-science speculation a bit. Octopi actually have neurons extending through their limbs. We don't. So when we talk about consciousness being "embodied", I'm sorry, it's an attempt to romanticize the question in a way that loses sight of our scientific understanding. Consciousness happens in the brain.

Sure, the brain needs stimulus from its embodied nervous system, and may even depend on those data and interactions in significant ways, but everything we know about consciousness suggests its in the brain. And so the data from "embodied" nervous systems may be important but there's no in-principle reason why it can't be accounted for in the context of preservation.

ninala · a year ago

> Octopi actually have neurons extending through their limbs. We don't.

You don't have neurons extending through your limbs?

ninala commented on Ask HN: Who is hiring? (December 2023) · Posted by u/whoishiring

ninala · 2 years ago

Nobias Therapeutics | Norcal/Mountain View/Palo Alto/SF; Philadelphia, PA; other locations welcome - particularly Boston, MA; Miami, FL; Austin, TX; REMOTE also acceptable (US, Canada, London/England, other countries considered on a case-by-case basis) | Full-Time | salary + equity

Hello HN! We have hired a number of people from this monthly "Who is hiring?" post. Please don't be put off by how spare our website is. We are doing very exciting work at the nexus of biology and computer science, and we would love to talk to you. If you've reached out recently but haven't heard back, we appreciate your patience as we work through a backlog of submissions. We have primary offices in Mountain View, CA and Philadelphia, PA - so even though we have a number of remote and hybrid employees, we're particularly excited about hiring local people.

Nobias is a new pharma startup using a variety of built-from-scratch, custom AI tools to speed drug development. As an early stage biotech, we use large repositories of biological data, bleeding edge deep learning techniques, automated reasoning, and computational biochemistry to discover and develop new medicines, diagnostics/biomarkers, and biological insights for a variety of diseases, particularly pediatric rare diseases. If you have strong programming chops, a background in machine learning, and deep knowledge of biology or computational chemistry, we would love to speak with you.

Multiple roles are available - right now we are particularly concentrating on expanding our stable of AI engineers who have deep expertise in modern ML techniques. You should understand these techniques at the deepest level possible, and be able to extend existing research and construct new concepts from scratch, while also understanding cell and molecular biology very well. Finally, we are also recruiting for a leader in Translational Research. This position will focus more on outstanding biology knowledge and the process of moving from concept to validation.

[our domain is nobiastx.com - our website is in flux, so please excuse the lack of detail!]

Please contact us at hn_recruiting {@} [our domain].

ninala commented on Researchers treat depression by reversing brain signals traveling the wrong way med.stanford.edu/news/all... · Posted by u/CharlesW

malauxyeux · 3 years ago

Maybe not even having kids, but being engaged in something fully.

From neuroscience, there's the default mode network.

https://en.wikipedia.org/wiki/Default_mode_network

> It is best known for being active when a person is not focused on the outside world and the brain is at wakeful rest, such as during daydreaming and mind-wandering.

Apparently, activation of the DMN is correlated to rumination, itself correlated to depression.

https://pubmed.ncbi.nlm.nih.gov/31655111/

Interestingly, one thing often suggested to counter depression these days – meditation – generally says right on the tin that you're supposed to get into a wakeful rest state, but specifically try to avoid daydreaming and mind-wandering.

(I should say that I'm no expert. Just passing along things that I've heard/read.)

Edit: formatting

ninala · 3 years ago

Broadly speaking, engaging in a task activates the task-positive network, which actively suppresses the default mode network [1][2][3]. This likely happens during meditation [4], as during properly done meditation, one is supposed to be focused on the task of breathing. But this can be interrupted, particularly by stray thoughts/salience/attention shifts [5].

[1] "The human brain is intrinsically organized into dynamic, anticorrelated functional networks", https://www.pnas.org/doi/abs/10.1073/pnas.0504136102

[2] "The Brain's Default Mode Network", https://www.annualreviews.org/doi/10.1146/annurev-neuro-0710... {search for 'task-positive'}

[3] "Neural antagonistic mechanism between default-mode and task-positive networks", https://www.sciencedirect.com/science/article/pii/S092523122...

[4] "Mantra Meditation Suppression of Default Mode Beyond an Active Task: a Pilot Study", https://link.springer.com/article/10.1007/s41465-017-0028-1

[5] "Modulatory interactions between the default mode network and task positive networks in resting-state", https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017816/

ninala commented on Ask HN: Who is hiring? (April 2023) · Posted by u/whoishiring

ninala · 3 years ago

Nobias Therapeutics | Norcal/Mountain View/Palo Alto/SF; Philadelphia, PA; other locations welcome - particularly Boston, MA; Miami, FL; Austin, TX. REMOTE also acceptable (US, Canada, London/England, other countries considered on a case-by-case basis) | Full-Time and INTERNS | salary + equity

Hello HN! We have hired a number of people from this monthly "Who is hiring?" post. Please don't be put off by how spare our website is. We are doing very exciting work at the nexus of biology and computer science, and we would love to talk to you. If you've reached out recently but haven't heard back, we appreciate your patience as we work through a backlog of submissions. We now have an office in Mountain View, CA - so even though we have a number of remote and hybrid employees, we're particularly excited about hiring local people and recruiting interns for the summer.

Nobias is a new pharma startup using a variety of AI tools to speed drug development. As an early stage biotech, we use large repositories of biological data, bleeding edge deep learning techniques, automated reasoning, and computational biochemistry to discover and develop new medicines, diagnostics, and insights for a variety of diseases, particularly pediatric rare diseases. If you have strong programming chops, a background in machine learning, and deep knowledge of biology or computational chemistry, we would love to talk to you.

Multiple roles available, particularly for ML engineers, computational biologists, and medicinal or computational chemists. We are also looking for product managers with experience or interest in the space. Finally, we are always on the lookout for exciting people with integrity, intelligence, and the desire to work in an AI pharma company, particularly people with other business skills (business development, HR/Payroll, executive assistant).

[our domain is nobiastx.com - our website is in flux, so please excuse the lack of detail!]

Please contact us at hn_recruiting {@} [our domain].

ninala commented on Ask HN: Who is hiring? (March 2023) · Posted by u/whoishiring

ninala · 3 years ago

Nobias Therapeutics | Norcal/Mountain View/Palo Alto/SF; Philadelphia, PA; other locations welcome - particularly Boston, MA; Miami, FL; Austin, TX; Boulder/Denver, CO; REMOTE also acceptable (US, Canada, London/England, other countries considered on a case-by-case basis) | Full-Time and INTERNS | salary + equity

Hello HN! We have hired a number of people from this monthly "Who is hiring?" post. Please don't be put off by how spare our website is. We are doing very exciting work at the nexus of biology and computer science, and we would love to talk to you. If you've reached out recently but haven't heard back, we appreciate your patience as we work through a backlog of submissions. We now have an office in Mountain View, CA - so even though we have a number of remote and hybrid employees, we're particularly excited about hiring local people and recruiting interns for the summer.

Nobias is a new pharma startup using a variety of AI tools to speed drug development. As an early stage biotech, we use large repositories of biological data, bleeding edge deep learning techniques, automated reasoning, and computational biochemistry to discover and develop new medicines, diagnostics, and insights for a variety of diseases, particularly pediatric rare diseases. If you have strong programming chops, a background in machine learning, and deep knowledge of biology or computational chemistry, we would love to talk to you.

Multiple roles available, particularly for ML engineers, computational biologists, and medicinal or computational chemists. We are also looking for product managers with experience or interest in the space. Finally, we are always on the lookout for exciting people with integrity, intelligence, and the desire to work in an AI pharma company, particularly people with other business skills (business development, HR/Payroll, executive assistant).

[our domain is nobiastx.com - our website is in flux, so please excuse the lack of detail!]

Please contact us at hn_recruiting {@} [our domain].

ninala commented on Ask HN: Who is hiring? (February 2023) · Posted by u/whoishiring

ninala · 3 years ago

Nobias Therapeutics | Northern California/Mountain View/Palo Alto/San Francisco; Philadelphia, PA; other locations welcome - particularly Boston, MA; Miami, FL; Austin, TX; REMOTE also acceptable (US, Canada, London/England, other countries considered on a case-by-case basis) | Full-Time | salary + equity

Nobias is a new pharma startup using a variety of AI tools to accelerate drug development and drive towards predictable discovery. As an early stage biotech, we use large repositories of proprietary biological data, bleeding edge deep learning techniques, automated reasoning, and computational biochemistry to discover and develop new medicines, diagnostics, and insights for a variety of diseases, particularly pediatric rare diseases. If you have strong programming chops, a background in machine learning, and deep knowledge of biology or computational chemistry, we would love to speak with you.

Multiple roles available, particularly for Deep Learning/ML engineers, computational biologists with expertise in systems biology, and extremely strong programmers looking to move into the biotech space. We are also looking for an operations/business development director (see our post here - https://www.linkedin.com/jobs/view/3416697042/). Finally, we are always on the lookout for exciting people with integrity, intelligence, and the desire to work in an AI pharma company, particularly people with other business skills (clinical operations, program management, executive assistant, other business roles, etc).

[our domain is nobiastx.com - our website is in flux, so please excuse the lack of detail!]

Please contact us at hn_recruiting {@} [our domain].

ninala commented on Coinbase’s chief product officer will leave with a $105M payday dlnews.com/articles/coinb... · Posted by u/ilamont

1024core · 3 years ago

He also had a terrible reputation of being an arrogant prick. People hated working for him (or so I've been told). I've heard he made grown people cry.

ninala · 3 years ago

None of that is true, so far as I know. I remember him as kind and considerate. That doesn't mean he wasn't demanding, but he was quite fair, and sensitive to the impact of his words and actions.

ninala commented on Coinbase’s chief product officer will leave with a $105M payday dlnews.com/articles/coinb... · Posted by u/ilamont

matthewaveryusa · 3 years ago

I'm always intrigued at people's carriers and where exactly the inflection point was. Looking at Surojit's career, it went something like this:

BS in CS at Kharagput, something like a US T2 university

MS in CS at Buffalo, something like a T2 univeristy,

Spend some years at IBM and Oracle as a developer/senior developer 200k/year ?

MIT Sloan MBA T1 world class

PM/Senior PM at Symantec for a year 200-300k/year?

Head of Payment products India at Google, 8 years rising though the ranks 300-500k/year?, did an externship of 2 years at flipkart as SVP

Then back to google as a VP 500-1.5MM/year?

CPO at coinbase made 150 million.

It looks like he moved around, leveraging his title to get senior roles between start-up and well-established companies:

PM at small company to PM at big company,

Head of product at big company to SVP at startup

SVP at startup to VP at big company

VP of big company to C-suite at startup pre-IPO

Most of all, he got in on the crypto gravy train right in time for his options to balloon

ninala · 3 years ago

I've worked with Surojit; he was an absolute superstar. He rose through the ranks on the basis of mountains of backbreaking and incredibly impactful work.

ninala commented on Consider working on genomics claymcleod.dev/blog/2022-... · Posted by u/clmcleod

YouWhy · 3 years ago

I am a career SW engineer that has worked on genomics in a startup. The field is genuinely exciting.

The endemic disease of the field is the leadership. A leadership made out of Principal Investigators forged in academia, appear simply incapable of producing any item which is not articles (or equivalents thereof).

ninala · 3 years ago

Do you think that's true of pharmaceuticals/biotechs as well? Or just academia?