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michihuber commented on Goldman Sachs asks in biotech Report: Is curing patients a sustainable business? (2018)   cnbc.com/2018/04/11/goldm... · Posted by u/randycupertino
stego-tech · a month ago
I feel kinda bad for the writer, because it's a good question: no, curing patients is not a good business model, just like public transit is not a good business model.

What a lot of folks neglect are N+1-order effects, because those are harder to quantify and fail to reach the predetermined decision some executive or board or shareholder has already made. Is curing patients a bad business model? Sure, for the biotech company it is, but those cured patients are far more likely to go on living longer, healthier lives, and in turn contribute additional value to society - which will impact others in ways that may also create additional value. That doesn't even get into the jobs and value created through the R&D process, testing, manufacturing, logistics of delivery, ongoing monitoring, etc. As long as the value created is more than the cost of the treatment, then it's a net-gain for the economy even if it's a net loss for that singular business.

If all you're judging is the first-order impacts on a single business, you're missing the forest for the trees.

michihuber · a month ago
Why would curing patients not be a good business model?

Of course it is, if you charge the right price, just like “building and selling (not leasing out) houses” can be a good business model.

No subscription or 2nd order effects needed.

michihuber commented on Grammarly acquires Superhuman   reuters.com/business/gram... · Posted by u/thm
isaachinman · 6 months ago
We're building what you want:

https://marcoapp.io

michihuber · 6 months ago
are you unifying the inbox across multiple mail accounts? (like apple Mail.app does)
michihuber commented on Ask HN: How to store and share passwords in a company?    · Posted by u/hu3
michihuber · a year ago
1password.com works well.
michihuber commented on Podcast-conversations with YC founders whose startups failed   open.spotify.com/episode/... · Posted by u/thinkwithlucie
eole666 · 4 years ago
90% of startups fail : https://review42.com/resources/what-percentage-of-startups-f... There is no surprise a startup is failing, most of them propose products nobody needs and are a big waste or time, energy and money.

But hey, creating a startup and trying to make it an unicorn is still trending. Still tons of people with too much money have a hobby investing in bullshit tech things, so there is hope for each founder to find a lot of founding money if they are good at selling their product idea, no matter how bad or good it actually is.

And then, when the initial cash flow runs dry, the startup fails, time to create another one !

michihuber · 4 years ago
so what? that’s the cost of making the other 10% happen.

and that’s how society becomes prosperous.

michihuber commented on Ask HN: Who is hiring? (February 2022)    · Posted by u/whoishiring
michihuber · 4 years ago
Arc Studio – Remote

Looking for a senior Clojure/ClojureScript dev – need some experience with frontend ClojureScript SPAs. Ideally wants to build and manage a small team (but mostly build and write code).

We're building a git/GitHub for screenwriters. Documents with branch-and-merge, versioning, and real-time collab. What if Google Docs was built for deep collaboration in the first place, instead of being Word with some collab tacked on?

Apply here: https://tally.so/forms/w8rqOm

michihuber commented on Ask HN: Why is building Windows apps so complicated?    · Posted by u/vixalien
michihuber · 4 years ago
Also, distribution: Windows Defender requires code signing with an extended validation certificate, or going through the Windows Store. Otherwise users see a scary warning after installation how your app is probably a virus.

But using an EV cert means you cannot build on a CD service (it comes on a dongl). And users hate the Windows Store.

What am I missing as a mac person? I hear that most apps aren’t on the Windows Store. Is it normal to just have a virus warning and people ignore it anyway? Or can you just not distribute through a CD service?

michihuber commented on Jam – Self-Hosted Clubhouse   github.com/jam-systems/ja... · Posted by u/synergy20
michihuber · 4 years ago
Nice, knew about Jam before, but just learned about jam-core. Will integrate into our app, thanks for sharing.
michihuber commented on Using Microsoft Word with Git   blog.martinfenner.org/201... · Posted by u/the_dripper
Atropos · 5 years ago
I am still working in big law and I disagree that the benefits of adopting more advanced version control would be small. However, I work in a field that is a mix of regulatory law and litigation, where almost no work is based on templates and most things are drafted from scratch.

One very large problem that typically comes up in large teams: Only 1 team member can edit the the "live version" of a document (it's locked for editing by the version control system), the other team members need to work "offline" and then reintegrate their changes/drafts into the main document. Everybody has lived through the horror story of a team member in the different time zone still having checked out the live version and going to sleep :)

Sometimes you have to circulate a draft document in parallel to multiple parties (e.g. colleagues with special subject expertise + client's inhouse lawyers + client's technical experts + other party's law firm + other party's inhouse lawyers + other party's technical experts). It can happen that you need to reintegrate comments from different parties to different versions of the drafts, e.g., if your client gives feedback quickly and you re-circulate updated version internally, then you receive other party's comments to the older draft version...

Besides the mechanical aspects of reintegrating comments, it is also difficult to track if everybody who needs to sign off has actually signed off on the parts of the documents they had to review. Often it gets lost who made which comment/change. It can be quite awkward if a regulator asks you "Isn't the technical statement on page 12 contradicted by fact XYZ" - please explain until tomorrow - and you have to quickly figure out who actually put that in...

michihuber · 5 years ago
Would you also email me so I can ask a few questions?

m@replace-with-my-username.com

Would be much appreciated!

michihuber commented on Using Microsoft Word with Git   blog.martinfenner.org/201... · Posted by u/the_dripper
tom1239 · 5 years ago
Similarly, I am a qualified lawyer. I previously worked in a big law firm in London, which describes itself internally as both the “best” and “the most advanced” law firm in the world. I now work full-time as an engineer in software, and increasingly in hardware.

I agree with both comments.

To add, in large-scale corporate/commercial practice (which is the area which I practised), Git would be useful in replacing email-based collaboration, but the switching costs seem too high.

Currently, the corporate law contract negotiation workflow is as follows:

1. a party adds their tracked changes to a Word document based on a template contract;

2. the party emails this document to party B;

3. party B reads the changes, may discuss the changes with their client, adds their tracked changes, and then emails the updated document to party A.

This process repeats for every document, punctuated by occasional conference calls between the parties, until the parties agree.

‘Git for law’ would be useful for lawyers in increasing efficiency - and thus reducing costs for clients.

However, the benefits for law firms of adopting a new Git-based workflow are likely to seem relatively small to lawyers. Their current email-based version control system is messy and time-inefficient, but generally functions with minimal error.

On this basis, I would predict that most corporate law firms would be very slow to adopt a Git-based system - the benefits may not justify the costs.

One should also note that lawyers, particularly contract/commercial lawyers, are conservative by profession. In my experience, most lawyers are very slow to adopt new technologies, highly risk-averse, and skilled at spotting risks. The combination of these traits means that any technology will have to offer a very high benefit to replace an existing legal workflow.

michihuber · 5 years ago
Tom, would also love to ask you a few questions via email.

m@replace-with-my-username.com

u/michihuber

KarmaCake day53February 18, 2013
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