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lentil_soup commented on CRISPR fungus: Protein-packed, sustainable, and tastes like meat   isaaa.org/kc/cropbiotechu... · Posted by u/rguiscard
adrian_b · 6 days ago
There are better alternatives than consuming the whole cells.

There have been other attempts to use genetically-modified fungi (Trichoderma) for protein production, where they secrete in the cultivation medium a water-soluble animal protein, e.g. a cow whey protein or chicken egg white protein.

Then, through filtration and ultrafiltration, the desired protein is separated from the fungal cells and the cultivation medium, producing a protein powder in the same way how one makes whey protein concentrate or milk protein concentrate.

If done correctly this method produces only healthy protein without contaminants.

However, searching right now online if there has been any progress with this, I see that against a startup company that has already produced such whey protein powder from a fungal culture there is a lawsuit that alleges that they have not separated properly the whey protein and that what they have sold contained more fungal protein of uncertain quality and safety than the good whey protein that they claimed to sell.

Even if that company might be guilty of trying to exploit the technology before being perfected, the principle is sound and there is no doubt that this can be done, producing pure high-quality protein.

I actually use whey protein concentrate to provide a significant fraction of my protein consumption, so I hope that its production from fungi will succeed in a not too distant future.

Trichoderma is among the fungi that secrete enzymes in their environment, so the genetic modification that replaced its enzyme with whey protein or egg albumin is much simpler than the many modifications described in the parent article in order to make the whole cells more palatable, without really achieving this.

For producing a protein powder that can be used as an ingredient in cooking food from vegetable sources, the approach used with Trichoderma is sufficient. The techniques used in the parent article are justified because they do not want to make a healthy food, but they want to make a meat imitation. For myself, enhancing the quality of vegetable food is a much more important goal than attempting to simulate meat, but at least in USA it is likely that the second goal might make more money.

lentil_soup · 5 days ago
>> There have been other attempts to use genetically-modified fungi (Trichoderma) for protein production, where they secrete in the cultivation medium a water-soluble animal protein

Honest question, what does "animal protein" mean here in regards to it being produced by a fungi? is it that it's the same as as one from a cow at the molecular level?

lentil_soup commented on Things I want to say to my boss   ithoughtaboutthatalot.com... · Posted by u/casca
firefoxd · 6 days ago
I know this will sound a bit cynical, but I've stopped putting too much care into my employer's product. I'll deliver work and perform my best, but I'm not killing myself over it.

I've built viable products where I poured my soul into it just for it to be tossed aside [0]. I've optimized processes that went from 12 hours job to 17 minutes, I was fired shortly after [1]. I even wrote on HN to get advice when I felt I cared more about my work and colleagues [2]. Instead, my boss was promoted and I was scrutinized.

So when I work with a boss that doesn't care and is mostly performative, unless we are building a product that makes the world a better place, I don't put too much heart into it. I make sure they pay me for my time, and I look for a better job.

[0]: https://news.ycombinator.com/item?id=42806948

[1]: https://news.ycombinator.com/item?id=38456429

[2]: https://news.ycombinator.com/item?id=21766903

lentil_soup · 6 days ago
I agree with you, but lately, given the state of my industry and my personal situation I've started to fear that my company is just going to burn if we don't succeed and I need to do as much as possible to prevent that as finding a similar role is going to be pretty damn hard, I also don't have the leverage I used to have a few years ago to just change jobs. All of that has lead me to break my back and confront my boss which is extremely uncomfortable and pushing me closer to burnout. Unsure what my point is other than I wish I had the space to not care
lentil_soup commented on Covid-19 mRNA Vaccination and 4-Year All-Cause Mortality   jamanetwork.com/journals/... · Posted by u/bpierre
sa-code · 13 days ago
> no increased risk of all-cause mortality

> study including 22.7 million vaccinated individuals and 5.9 million unvaccinated individuals

These are the important bits for the non medical folks

lentil_soup · 12 days ago
And this bit:

"vaccinated individuals had a 74% lower risk of death from severe COVID-19 and no increased risk of all-cause mortality"

lentil_soup commented on Kenyan court declares law banning seed sharing unconstitutional   apnews.com/article/kenya-... · Posted by u/thunderbong
estsauver · 13 days ago
For some context on why the original law was introduced:

When you're making a seed that you want to make the best crop possible, the way to do that is to take two great lines of maize that share relatively little genetics, cross them at the last step, and enjoy the hybrid vigour that results. This is one of the most important practical advancements we have for getting good yields from crops: the yields are dramatically better for this seed then if you plant the seed kernels that are made by the hybrid. When you plant saved seed (which many poor people are forced to do through not being able to afford hybrid seeds) you get dramatically worse yields and often even doing things like using fertilizer doesn't make economic sense (https://www.hks.harvard.edu/publications/low-quality-low-ret... is frequently cited.)

However, to the naked eye, there's basically no distinction between a hybrid seed and stored seed. A lot of seed companies sell seeds that are coated to help protect the seeds from pests/blights, but seed counterfitters have learned how to copy this. To distinguish them, you either need to run genetic testing or plant them and wait a season. If you get scammed, the result can be devestating for a smallholder farmer's family.

I don't necessarily think community seed banks should be banned, but I think it's important context to know. There are people for whom they really need any seed, crops which are not served commercially well, and a whole bunch of other use cases I immediately understand for a community seed bank. But seed counterfitting is a real problem that is hurting some of the world's poorest people. (I'll also just say I'm not up to date on this law, the court case, or how it's been applied in the country.)

Disclaimer: I'm one of the founders of Apollo Agriculture and still serve on the board, which operates in Kenya and a few other countries trying to help smallholders get access to better agtech (which includes hybrid seeds and fertilizer and other high roi agricultural tools.)

lentil_soup · 13 days ago
I don't understand the context. The idea of banning seed sharing is to stop counterfeits? That doesn't make much sense. Surely that'll just make it worse, no?

Also, what's the connection to the high yield ones? Is it because those get counterfeited the most?

lentil_soup commented on Ultra-processed food linked to harm in every major human organ, study finds   theguardian.com/society/2... · Posted by u/lentil_soup
mr_mitm · a month ago
If you are asking the question whether UPF is bad, surely you got to control for the amount. Of course you can say that people tend to eat too much of UPF simply because it is easier to prepare and eat, but that doesn't mean it's the processing that is bad for you. It's still just the amount.
lentil_soup · a month ago
But that's part of it. There's a part to do with the nutrient quality, which can also be talked about, but also a part that has to do with how UPF are consumed. The act of processing the food a certain way makes you eat more of it without realising it. Same with fat and sugar, eating a stick of butter on its own is hard, same with pure sugar, mix them up and it's delicious and addictive which leads to health problems.
lentil_soup commented on Ultra-processed food linked to harm in every major human organ, study finds   theguardian.com/society/2... · Posted by u/lentil_soup
general1465 · a month ago
Yeah the whole definition is bogus. i.e. "mechanically separated meat" is considered ultraprocessed food? Why? By this logic putting apples into mixer and creating pyre is ultraprocessed food too.
lentil_soup · a month ago
Apples are actually a great example.

Think of eating an apple vs drinking apple juice. The amount of entire apples you can drink is immense compared to eating the apple whole. So the mechanical process does affect how we consume the food.

lentil_soup commented on Ultra-processed food linked to harm in every major human organ, study finds   theguardian.com/society/2... · Posted by u/lentil_soup
stephen_g · a month ago
I’ve seen one theory that it might be something to do with not needing as much chewing and how quickly you can eat it. I can’t remember exactly the article I was reading but apparently there is a massive difference (e.g. insulin spike, etc.) eating apple purée of one apple vs. eating an apple.

Needing to chew less processed food may help just by being kind of rate-limiting (slowing down how fast you can get the food in), but also the enzymes in your saliva have time to start working on the food before you swallow it.

If I recall correctly I have also read (perhaps the same article, but maybe somewhere else) that some processes related to digestion might be triggered when you start eating (chewing), so the fact that you can eat so many calories so quickly before those processes get going might make a big difference too.

lentil_soup · a month ago
as I understand, it's also the fiber. The fiber acts as a barrier that slows down the speed at which you absorb the food which leads to a smoother insulin spike (in case of carbs) and a faster feeling of satiation. When you blend the apple all that fiber is broken down do it loses those properties

u/lentil_soup

KarmaCake day3699October 9, 2014View Original