Watch out, there is no reliable Mouse Model for Alzheimer's. I was deeply involved with mouse models at some point before quitting my phd in neuroscience and I quite remember that.
Could you share some sources that show this to be true?
Readit Newskovek commented on Lithium compound can reverse Alzheimer’s in mice: study hms.harvard.edu/news/coul... · Posted by u/highfrequency
kovek commented on We may not like what we become if A.I. solves loneliness newyorker.com/magazine/20... · Posted by u/defo10
This is a great example of what I'm talking about in regards to humans vs AI. First you misunderstand my comment, barely even responding to it, then you paint me as defensive even though I've been very open and the absolute opposite of defensive. It's actually you who is being defensive now, starting on a clear attack and painting me into some kind of scared recluse corner, somebody who supposedly can't even understand why socialising is important and telling me to go talk to my AI friends to figure it out. I mean you gave a great example of a toxic, hurt human ego here, showing the incredible value of AI friends in the future. Because who would choose such a type of conversation over an empathetic, kind AI that cares and understands what I typed? For example an AI would understand that I'm not just talking about a chatbox on a phone, I've clearly mentioned full robots and this is all a forward looking conversation about future AI which will have bodies and can interact like humans. There is going to be real competition for humans soon and I think people are overestimating the value of humans a lot.
Why are you socializing with humans on Hacker News right now?
The incredible technology you're describing was possible on the Nintendo DS without wires and no need for a LAN either. It's a problem that's been solved in hundreds of different ways over the last 40 years but certain people don't want that problem to ever be solved without cloud services involved.
This dumb pipe thing is certainly interesting but it will run into the same problem as the myriad other solutions that already exist. If you're trying to give a 50MB file to a Windows user they have no way to receive it via any method a Linux user would have to send it unless the Windows user has gone out of their way to install something most people have never heard of.
> It's a problem that's been solved in hundreds of different ways over the last 40 years
I guess now you can find the solution that you need by telling the requirements to LLMs who have now indexed a lot of the tradeoffs
kovek commented on America’s incarceration rate is in decline theatlantic.com/ideas/arc... · Posted by u/paulpauper
This is interesting. I don't know why it's happening. However, this book deserves a mention: https://en.wikipedia.org/wiki/The_Better_Angels_of_Our_Natur... . It shares statistics on how violence has been decreasing throughout the history of humanity.
kovek commented on Self-Adapting Language Models arxiv.org/abs/2506.10943... · Posted by u/archon1410
> Large language models (LLMs) are powerful but static; they lack mechanisms to adapt their weights in response to new tasks
The learning and inference process are entirely separate, which is very confusing to people familiar with traditional notions of human intelligence. For humans, learning things and applying that knowledge in the real world is one integrated feedback process. Not so with LLMs, we train them, deploy them, and discard them for a new model that has "learned" slightly more. For an LLM, inference is the end of learning.
Probably the biggest misconception out there about AI. If you think LLMs are learning, it's easy to fantasize that AGI is right around the corner.
What if you can check if the user responds positively/negatively to the output, and then you train the LLM on the input it got and the output it produced?
kovek commented on Show HN: iOS Screen Time from a REST API thescreentimenetwork.com/... · Posted by u/anteloper
This is great! I am really interested in trying this out. Also, I am wondering, are there solutions similar to this but on MacOS?
What's different is intention. A human would have the intention to blackmail, and then proceed toward that goal. If the output was a love letter instead of blackmail, the human would either be confused or psychotic. LLMs have no intentions. They just stitch together a response.
Don't humans learn intentions over their life-time training data?
I've been kicking around idea for a similar open source project, with the caveats that:
1. I'd like the backend to be configured for any LLM the user might happen to have access to (be that the API for a paid service or something locally hosted on-prem).
2. I'm also wondering how feasible it is to hook it up to a touchscreen running on some hopped-up raspberry pi platform so that it can be interacted with like an Alexa device or any of the similar offerings from other companies. Ideally, that means voice controls as well, which are potentially another technical problem (OpenAI's API will accept an audio file, but for most other services you'd have to do voice to text before sending the prompt off to the API).
3. I'd like to make the integrations extensible. Calendar, weather, but maybe also homebridge, spotify, etc. I'm wondering if MCP servers are the right avenue for that.
I don't have the bandwidth to commit a lot of time to a project like this right now, but if anyone else is charting in this direction I'd love to participate.
Why not use a smartphone for the user interface?
kovek commented on Gemini Live with camera and screen sharing capabilities blog.google/products/gemi... · Posted by u/agnosticmantis
I think it would be nice if the Pixel Fold could do: Have a browser on the left showing some content, and have Gemini on the right, where you can prompt it with questions or asking it to take actions on the left.
kovek commented on How the Index Card Cataloged the World (2017) theatlantic.com/technolog... · Posted by u/Tomte
I still carry a "Hipster PDA"[1] around, binder clip and all. Said binder clip came out of a box from the 1970s.
It's immensely useful in a pinch, it's free form, and I can place it flat on a surface and write on it.
And, if I write sensitive information on a card, unlike a regular pocket notebook, I can store it or take a secure photo of it and physically pitch that index card.
Thanks, Merlin Mann[2].
I find that when carrying the Hipster PDA in a pocket, the index cards curl up and get bent. However, it almost satisfies all my requirements for a portable note-taking device.