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johnwdefeo commented on Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2?   biorxiv.org/content/10.11... · Posted by u/johnwdefeo
beiller · 3 years ago
I have the opposite Occam's razor thoughts. My opinion is we are not capable of developing in a lab a virus that is so transmissible and survivable in human species only. I think the complexity of the virus machinery and its interactions inside of our bodies and immune system is beyond astronomical in complexity. It's laughable to suggest that we are so intelligent as to invent a better version of the machinery that is hypothesized as the very machinery responsible for creation of multi cellular life itself.
johnwdefeo · 3 years ago
Speaking as an artist, many (most?) of my enduring works were the result of an accident of some kind. I call them "happy accidents" because I recognized that the mistake was better than whatever the vision was that I had at the time.

As a corollary, there are unhappy accidents, and with respect to life forms in a chaotic system, such accidents can perpetuate and endure without human recognition.

johnwdefeo commented on Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2?   biorxiv.org/content/10.11... · Posted by u/johnwdefeo
jgeada · 3 years ago
So a likely extremely controversial paper being shared publicly to a non-expert audience prior to any peer-review.

Is this going to be yet one more of those “will be withdrawn after peer scrutiny but by then it is too late because the false meme has been injected into the public consciousness” things?

johnwdefeo · 3 years ago
I sincerely hope not. From one of the authors:

"Scientists publish papers not because the paper is the end of science, but because it is a unit of research that is valuable to share with others so that others can use this brick of knowledge and either build with it… or find its weakness and break it down...We wrote our entire analysis in R and shared our code with the world. I tried SO hard to check every single line of code and make our pipeline clear & easy to reproduce. However, despite nearly giving myself stomach ulcers checking every line and stressing about these findings, it’s possible someone finds a mistake in our work. We don’t share this work happily - this is the saddest paper I’ve ever written. We’ve shared our code precisely for that reason: we want you to see exactly what we’ve done, and if we’ve done something wrong we are open to hearing it."

As to your original concern, it is a valid one. I wrote this is response to pre-prints popularized via the press earlier this year:

-> Make bold, unjustifiable claims in the preprint; -> Ensure widespread coverage in the science press; -> Walk back those claims during peer-review; -> Get published; and then -> Watch blue checks tout original claims as "Fact!"

u/johnwdefeo

KarmaCake day530October 9, 2020View Original