There's a bunch of stuff coming out about his coordination with Epstein to run pandemic simulations, and a lot of business level stuff going on after Epstein's initial run-ins with the law. That aside if he's on a personal enough level to ask him for antibiotics to sneakily slip his wife, then Bill would definitely know about all the rest.
Really don't have any more room to give these people the benefit of doubt.
If you’re Bill/Melinda and you’re undertaking a massive project to change the world positively, why not take money from Epstein? The public benefit would dwarf whatever benefit Jeff could obtain.
1 - Piles of parents too stupid or lazy to, well, parent the children they made;
2 - A very reasonable societal expectation that it shouldn't be easy for young kids to access, or even be exposed, to the worst dregs of the internet;
3 - Very different use cases (gaming, kids stuff, free/affordable slack for communities) all on the same platform;
4 - A pile of morons in legislatures who insist there's a magic highly private way to do all this, but (see Australia) refuse to lay out the actual method. It's a government-wide game of underwear gnomes.