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bognition commented on Anxiety disorders tied to low levels of choline in the brain   medicalxpress.com/news/20... · Posted by u/clumsysmurf
LatteLazy · a month ago
The most annoying thing about pieces like this is how easy it would be to actually test the hypothesis. They could just give people choline (double blind placebo including some participants who are not anxious). And test the effect on both choline levels and anxiety.

It’s also ready sold OTC.

Instead people just sit around and do meta studies on meta studies on correlation and publishing whatever statistical anomalies they can find.

bognition · a month ago
I can understand why this may seem simple, but when it comes to the brain almost nothing is simple.

Choline a key component in Acetylcholine is the primary neurotransmitter used in your hippocampus. Its an excitatory neurotransmitter meaning it turns neurons on. The hippocampus is a massive parallel feedback circuit that when over stimulated can and will begin to seize. In fact many people who suffer from seizures have over active hippocampal circuitry. Simply "flooding" the brain with more choline could have very very bad effects.

Likewise, taking choline might not work as the brain actively controls and regulates the contents of the cerebral spinal fluid. Unlike the rest of your body, the capillaries in the brain are not leaky, but instead are enshrouded in the blood-brain barrier and there are active transport proteins for anything that isn't lipid soluble.

Choline is actively transported into the brain and the brain has additional internal mechanisms to regulate the levels of choline.

Lastly, neurotransmitters aren't just floating around in the soup of your brain. They are released by specific neurons which are integrated into specific circuits. Parkinson's disease is a perfect example here. There is tiny region of the brain involved in regulating voluntary movements that is rich in dopamine neurons. For Parkinson's these neurons die off while the rest of the brain remains relatively strong. Simply putting dopamine into the brain doesn't fix the issue you need to up the dopamine released by these specific neurons.

The treatment here is l-dopa which is a precursor to dopamine which does this, but once those neurons are gone they're gone and there is little we can do to stop the disease.

So if this works for l-dopa why won't it work for choline? My guess is because of the tight regulation the brain has around choline levels as its needed to prevent the hippocampus from seizing up.

bognition commented on Modular monolith and microservices: Modularity is what matters   binaryigor.com/modular-mo... · Posted by u/BinaryIgor
bognition · a month ago
Hard agree with this article. Split up your application by domains, create public apis between modules, understand your dep tree and keep it clean.

The devil in the details is how you pull something like this off. At the end of the day is boils down to how do you enforce that your team does the right thing. You can have a single person that enforces standards with an iron fist, but this doesn't scale. You can teach everyone how this should work, but you're going to experience drift over time as people come and go. Or you can enforce it using technology and automation.

In the cases of the first choice, its going to restrict how big your team can get and will end up eating all of the time of your one person.

In the case of the second choice, a combination of the tragedy of the commons and regression to mean will degrade the system to spaghetti code.

For the third scenario language choice matters here a lot. In Java with multi maven modules you can setup maven to forbid imports of specific module types allowing you to make modules as private/public. In Python you can't do any of this.

bognition commented on Smartphones manipulate our emotions and trigger our reflexes   theconversation.com/smart... · Posted by u/PaulHoule
changadera · 2 months ago
"Guns don't kill people..."
bognition · 2 months ago
Not sure if you’re being coy or pushing the trope but you’re right guns don’t actually kill people. The bullets and blood loss tend to do that.

That said, denying people access to guns does result in fewer gun related fatalities.

bognition commented on Rivian's TM-B electric bike   theverge.com/news/804157/... · Posted by u/hasheddan
h14h · 2 months ago
IMO a huge missed opportunity for these indirect-drive bikes is marketing them as a home exercise bike 2-in-1.

If the pedals are going into a generator with fancy software to emulate the feel of a bike, there's nothing stopping the bike from going into "stationary mode" and acting as an exercise bike. This thing even had a screen on it, so you could do workouts like a peloton.

Then there's the storage aspect -- many people already have (or want) to allocate space to an exercise bike. It would pretty compelling that was also the parking space for your bike-bike.

Then there's the added benefit that your workout is charging the battery. Imagine biking to a park on low charge, doing a stationary workout, and then having enough battery left to bike home with full assist.

bognition · 2 months ago
Its an interesting idea and the engineer in my agrees with you. Then the product skeptic says that anyone who wants to ride a bike as a form of exercise and get around using a bike, would probably just ride a normal bike.
bognition commented on Uv overtakes pip in CI   wagtail.org/blog/uv-overt... · Posted by u/ThibWeb
gatvol · 2 months ago
UV is super fast and great for environment management, however it's not at all well suited to a containerised environment, unless I'm missing something fundamental (unless you like using an env in your container that is).
bognition · 2 months ago
Why not?

In my docker files I use `uv sync` to install deps vs `pip install -f requirements.txt`

And then set my command to `uv run my_command.py` vs calling Python directly.

bognition commented on Uv overtakes pip in CI   wagtail.org/blog/uv-overt... · Posted by u/ThibWeb
ThibWeb · 2 months ago
for me the surprise is the pace? I’d expect people to be more set in their tools that it takes longer than a few months for a new tool, no matter how good, to become the majority use one. Though perhaps people adopt new tools more easily in CI where install times matter more
bognition · 2 months ago
Honestly, I was skeptical when I learned about uv. I thought, just Python needs, another dependency manager… this was after fighting with pip, venv, venvwrapper, and poetry for years.

Then I gave it a try and it just worked! It’s so much better that I immediately moved all my Python projects to it.

bognition commented on Uv overtakes pip in CI   wagtail.org/blog/uv-overt... · Posted by u/ThibWeb
bognition · 2 months ago
This shouldn’t be a surprise to anyone who has been using Python and has tried uv.

Python dependency management and environments have been a pain for 15 years. Poetry was nice but slow and sometimes difficult.

Uv is lightning fast and damn easy to use. It’s so functional and simple.

bognition commented on How HubSpot scaled AI adoption   product.hubspot.com/blog/... · Posted by u/zek
catigula · 3 months ago
>measurable but modest productivity improvements

No mention of how this was measured.

bognition · 3 months ago
> We pulled metrics on code review burden, cycle time, velocity comparisons before and after adoption, and production incident rates.
bognition commented on How HubSpot scaled AI adoption   product.hubspot.com/blog/... · Posted by u/zek
bognition · 3 months ago
Honestly its been pretty wild to see this company succeed over the years. They took on Salesforce and everyone predicted they were going to fail. Yet year over year they've continued to succeed.

u/bognition

KarmaCake day3691October 22, 2013View Original