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beardface commented on Elasticsearch is open source, again   elastic.co/blog/elasticse... · Posted by u/dakrone
unethical_ban · 2 years ago
Okay, cool. No notes, that's neat.

Are there any SMEs that have worked with both OpenSearch (the fork) and ElasticSearch? Are there significant differences?

I know the AWS fork had the big difference back then of having RBAC built into their Kibana portion.

beardface · 2 years ago
For most use-cases (indexing denormalised data as documents then running searches against them), there's little difference between the two. The mechanics of how the cluster operates are almost identical.

There are some Elasticsearch features that were part of X-Pack (their commercial offering) so aren't included in the OpenSearch fork. Some of those features are really nice to have and make life much easier; the enrich ingest processor is something I really miss in OpenSearch.

The biggest differences are in the tooling around Elasticsearch. All the observability stuff, the SIEM features, various integrations, and now the AI fluff. I've worked with clients in different sectors and - aside from the observability stuff (which is really nice) - none have had an appetite for any of that.

The OpenSearch team is doing some really cool stuff and the project has come a long way. I'm sure it'll continue to improve. It has a very loyal customer base and even has its own annual event; OpenSearchCon 2024 is next month!

beardface commented on Immunotherapy Is Changing Cancer Treatment Forever   nymag.com/intelligencer/a... · Posted by u/bookofjoe
borbulon · 2 years ago
I was recently released from a clinical trial because of too many “newly measurable” areas of tumor. I was offered CAR-T but was told that it comes with a high risk of possibly fatal infections and is not guaranteed to work at all for my cancer (HER-2 positive lung cancer, stage 4). I turned it down. I have a wife and 3 kids, I’d rather spend an unknown amount of time being fully present with them than risk my life today.
beardface · 2 years ago
My Mum went through CAR-T for lymphoma earlier this year. It's a brutal therapy but can offer benefits in the long term.

As you mentioned, the big issues are around infections. It completely wipes out the immune system, including all vaccinations. Every vaccination needs to be taken again, once the body is recovered from the initial therapy.

My Mum recently contracted COVID and is in hospital being given Paxlovid. She had COVID a while ago and it was nothing compared to her current state. CAR-T made it significantly worse but will hopefully be worth it in the long term.

I'm saddened by your news but - given what I've experienced with my Mum during her cancer journey - can understand the difficult decision you've made.

beardface commented on Vitamin D supplementation and incident dementia   alz-journals.onlinelibrar... · Posted by u/bookofjoe
CharlesW · 3 years ago
Hey people who follow the science: As an “indoor human”, how much should I be taking? (TIA!)
beardface · 3 years ago
I would advise taking a K2 MK7 supplement with D3, or get a supplement that contains both. Personally, I take one capsule a day that contains both 3000IU of D3 and 100μg of K2 MK7.

D3 by itself can cause high calcium levels, to the point of toxicity in very high doses. The K2 moves the calcium from the blood to bones.

beardface commented on Apple Makes Major Progress on No-Prick Blood Glucose Tracking for Its Watch   bloomberg.com/news/articl... · Posted by u/mfiguiere
bilsbie · 3 years ago
I’m more interested in seeing my insulin levels than blood sugar. But I guess that’s not happening anytime soon.
beardface · 3 years ago
Insulin levels are massively overlooked. You can have normal blood glucose but excessive insulin levels due to insulin resistance, which leads to type 2 diabetes.

As another poster mentioned, it won't happen either invasively or non-invasively any time soon. Insulin levels aren't even part of a standard blood test in most places due to the cost.

beardface commented on Apple Makes Major Progress on No-Prick Blood Glucose Tracking for Its Watch   bloomberg.com/news/articl... · Posted by u/mfiguiere
__jf__ · 3 years ago
I was primarily struck by the awesomeness of this whole autonomous glucose regulation thing. My last meal is usually around 18:30 in the evening and during the night glucose would fluctuate around 4.5 mmol/l between 4.0 and 5.0 in 1 hour periods, like a crappy PID controller that needs a firmware update. Other nights it would be flat instead of fluctuating, but unfortunately two weeks were too short for a controlled experiment, meal repeats and figuring out what caused the difference. Some nights it would show a couple of hypo's where glucose would drop to 3.5, quickly to be countered by an increase. I didn't notice a thing.

Additionally every morning before my alarm went off, I could see my glucose increasing, most likely preparing for wakeup, all by itself. Amazing!

It gave me a new-found respect for these otherwise invisible processes happening in this fleshy vessel on autopilot with closed cockpit doors. I only got to peek through a small window during 2 weeks.

beardface · 3 years ago
Now imagine having that entire responsibility yourself, having to do it all manually. That's what we type 1 diabetics do every day!

The nighttime fluctuations could be legit changes in glucose level, but could also be weird sensor issues. The sensor will often give low readings when lying on it in your sleep. These are referred to as 'compression lows'.

The morning glucose spike you noticed is called the 'dawn phenomenon'. I inject a little insulin every morning to counteract it.

beardface commented on Time-restricted eating reduces visceral fat and improves metabolic syndrome   cell.com/cell-reports-med... · Posted by u/nabla9
agacera · 3 years ago
Thanks for sharing this.

Did you notice any improvements with your condition (type 1 diabetes) once you started to do intermittent fasting?

beardface · 3 years ago
It's difficult to tell if IF alone had a change because I also switched to a very low carbohydrate diet at pretty-much the same time. The two combined had a massively positive effect on my diabetes.

My glucose level is much more stable, and A1C is lower. I also use significantly less insulin than a lot of people with type 1 diabetes.

My reason for doing both was to reduce insulin levels as much as possible.

beardface commented on Ask HN: How did you stop drinking?    · Posted by u/chrisgd
marginalia_nu · 3 years ago
I've found it easy to stop a great deal of such behaviors by examining not what they promise to deliver, but what they actually brought. I.e. don't look forward, look backward when making decisions.

Alcohol promises a great time. Alcohol delivers a hangover and regrets.

Junk food promises a great time. Junk food delivers poor health and regrets.

Going to the gym promises hardship and struggle. It delivers health. I've never once regretted it.

Reading a book promises struggling and boredom. It delivers wisdom and inspiration. I've never once regretted it.

If you compare what you think you will happen with what you know will happen from experience, it's very easy to see how often you are misjudging these things.

beardface · 3 years ago
The problem with looking at what something delivers is that the time between taking the action and noticing what was delivered. There's often days, weeks, or even months (especially in the case of going to the gym) between doing something and seeing a difference.

When taking a new action (or new inaction), you can even feel worse before feeling better.

It's a good idea but the temporal component skews everything.

Habit formation, even if it's a new habit of not doing something, is something that's worked for me in the past.

beardface commented on Time-restricted eating reduces visceral fat and improves metabolic syndrome   cell.com/cell-reports-med... · Posted by u/nabla9
throwaway290 · 3 years ago
Is a cup of coffee (with/without milk) outside of the 8-hour window considered a breach of TRE?
beardface · 3 years ago
Type 1 diabetic here. My body doesn't produce insulin, so if my glucose level goes up after eating or drinking something, that increase in glucose is a (very) approximate measure of insulin response in someone without type 1 diabetes. Insulin is released/produced/injected in response to glucose level increase (and other signals in someone who doesn't have type 1 diabetes).

In my experience, black coffee is absolutely fine outside of an eating window. I fast for at least 18 hours a day, only drinking black coffee and water when fasting. There was no measurable difference in glucose on occasions when I drank black coffee, vs occasions without (all other things as equal as possible).

beardface commented on The best apples for apple pie   seriouseats.com/the-food-... · Posted by u/djoldman
beardface · 3 years ago
No mention of Grenadier apples, unfortunately. Perhaps understandably so.

They're impossible to find in most shops due to them not storing well and being quite ugly. We have a tree in our garden and the apples are outstanding for pies, crumbles, cobblers, and Charlottes. They can hold their shape well, or turn to a delicious purée if cooked longer.

beardface commented on WeatherKit   developer.apple.com/weath... · Posted by u/ag8
dieselgate · 4 years ago
Apple api - nope. Norwegian Meteorological Institute api - yup.

That’s mostly in jest though (sent from an iphone) but also because Apple bought darksky (which was my preferred weather api/source in the past) and I’d assume that’s a big part of/rolled into the weatherkit offerings now?

beardface · 4 years ago
I've been using Dark Sky for years but I uninstalled it yesterday. Since the acquisition, the native Weather app has been massively upgraded with a lot of Dark Sky's best features and is very good now.

I ran the two in parallel for a few months to compare the alerts and accuracy. Weather won out.

u/beardface

KarmaCake day106September 26, 2018View Original