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avarun commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
A_D_E_P_T · 7 days ago
lol, that one was really a howler.

You're spot on. But for the rest of the forum:

The most commonly accepted mouse-to-human conversion is: (D)*(3/37) = H

Where D = the mouse dose in mg/kg. H = human dose in mg/kg.

So if a 25g mouse eats 0.1% of its bodyweight in taurine, that comes out to 1000mg/kg. It translates to 81mg/kg for a human. If you weigh 100kg, an equivalent daily dose for you is 8.1 grams/day.

The rat equation is similar, but 6/37 rather than 3/37.

avarun · 7 days ago
In plain English: scale by body weight then divide by 12.
avarun commented on Gemma 3 270M: Compact model for hyper-efficient AI   developers.googleblog.com... · Posted by u/meetpateltech
layer8 · 10 days ago
Doesn’t the “M” in “Gemma 3 270M” Stand for “male”?

Also: https://en.wikipedia.org/wiki/Gemma_Frisius

avarun · 10 days ago
Not sure if that’s a serious question but it stands for “million”. As compared to 1B+ models, where the B stands for “billion” parameters.
avarun commented on Andrej Karpathy: Software in the era of AI [video]   youtube.com/watch?v=LCEmi... · Posted by u/sandslash
orbital-decay · 2 months ago
This is what mechanistic interpretability studies are trying to achieve, and it's not yet realistically possible for a general case.
avarun · 2 months ago
Similarly to how you can never guarantee that one of your trusted employees won’t be made a foreign asset.
avarun commented on The Zed Debugger Is Here   zed.dev/blog/debugger... · Posted by u/SupremumLimit
jaoane · 2 months ago
They don’t support windows, they don’t support regular screens on Linux… are they a Mac shop basically?
avarun · 2 months ago
Most startups are
avarun commented on FTC takes action against Uber for deceptive billing and cancellation practices   ftc.gov/news-events/news/... · Posted by u/pinewurst
woodruffw · 4 months ago
> even for people living in a place with public transport as encompassing as say NYC, you _need_ some form of ride-sharing service eventually in day-to-day life

Not really. You can say this about smaller US cities, but NYC is absolutely a city where the >90% percentile of people can live without the daily use of a car.

(The simplest reason for this has nothing do to with car ownership or desirability per se: it's because of NYC's food delivery happens by bike or moped.)

avarun · 4 months ago
This is a strawman if I've ever seen one. The person you're responding to said literally nothing about "daily use of a car". The point was that you need rideshare at some point in your life, which is a point you failed to respond to. There are trips, even in NYC, where you'd be severely inconveniencing yourself by not using rideshare, which makes it a tough calculus to choose between $20 and being banned from Uber for life.
avarun commented on Ending our third party fact-checking program and moving to Community Notes model   about.fb.com/news/2025/01... · Posted by u/impish9208
Henchman21 · 8 months ago
Please provide one example of your assertion.
avarun · 8 months ago
Noah Smith’s entire twitter feed is dedicated to pointing out progressive lies.
avarun commented on Why is it so hard to buy things that work well? (2022)   danluu.com/nothing-works/... · Posted by u/janandonly
georgewfraser · 8 months ago
I have some insight into this because this claim is about my company Fivetran:

“…relies on the data source being able to seek backwards on its changelog. But Postgres throws changelogs away once they're consumed, so the Postgres data source can't support this operation”

Dan’s understanding is incorrect, Postgres logical replication allows each consumer to maintain a bookmark in the WAL, and it will retain the WAL until you acknowledge receipt of a portion and advance the bookmark. Evidently, he tried our product briefly, had an issue or thought he had an issue, investigated the issue briefly and came to the conclusion that he understood the technology better than people who have spent years working on it.

Don’t get me wrong, it is absolutely possible for the experts to be wrong and one smart guy to be right. But at least part of what’s going on in this post is an arrogant guy who thinks he knows better than everyone, coming to snap conclusions that other people’s work is broken.

avarun · 8 months ago
The kind of arrogance this comment displays has ensured that I’ll try my best to never use Fivetran anywhere I work ever again.
avarun commented on Cold Email Handbook   za-zu.com/blog/playbook... · Posted by u/baxtr
ChilledTonic · 8 months ago
There was a startup about a decade ago when crypto was just kind of becoming a mainstream-ish thing, where if someone emailed you, it would intercept it if it wasn’t on your contact list, and the app would automatically ask them for a bitcoin bribe to have you actually get the email to land in your inbox.

I wonder weekly whatever happened to that company. I wish it took off.

I get 100+ emails like this “handbook” a day and discard all of them. Want my attention? Spend your ad dollars on it, literally.

avarun · 8 months ago
You're referring to Balaji Srinivasan's startup, Earn, right? It was acquired by Coinbase and became Coinbase Earn, at which point Balaji became Coinbase's CTO, around 2018. I believe it's since been shut down.
avarun commented on ChatGPT Pro   openai.com/index/introduc... · Posted by u/meetpateltech
lumb63 · 9 months ago
Famously, the last 10% takes 90% of the time (or 20/80 in some approximations). So even if it gets you 80% of the way in 10% of the time, maybe you don’t end up saving any time, because all the time is in the last 20%.

I’m not saying that LLMs can’t be useful, but I do think it’s a darn shame that we’ve given up on creating tools that deterministically perform a task. We know we make mistakes and take a long time to do things. And so we developed tools to decrease our fallibility to zero, or to allow us to achieve the same output faster. But that technology needs to be reliable; and pushing the envelope of that reliability has been a cornerstone of human innovation since time immemorial. Except here, with the “AI” craze, where we have abandoned that pursuit. As the saying goes, “to err is human”; the 21st-century update will seemingly be, “and it’s okay if technology errs too”. If any other foundational technology had this issue, it would be sitting unused on a shelf.

What if your compiler only generated the right code 99% of the time? Or, if your car only started 9 times out of 10? All of these tools can be useful, but when we are so accepting of a lack of reliability, more things go wrong, and potentially at larger and larger scales and magnitudes. When (if some folks are to believed) AI is writing safety-critical code for an early-warning system, or deciding when to use bombs, or designing and validating drugs, what failure rate is tolerable?

avarun · 9 months ago
> Famously, the last 10% takes 90% of the time (or 20/80 in some approximations). So even if it gets you 80% of the way in 10% of the time, maybe you don’t end up saving any time, because all the time is in the last 20%.

This does not follow. By your own assumptions, getting you 80% of the way there in 10% of the time would save you 18% of the overall time, if the first 80% typically takes 20% of the time. 18% time reduction in a given task is still an incredibly massive optimization that's easily worth $200/month for a professional.

avarun commented on Amazon to invest another $4B in Anthropic   cnbc.com/2024/11/22/amazo... · Posted by u/swyx
cma · 9 months ago
> But I can tell the quality drops even when you do that

Dario said in a recent interview that they never switch to a lower quality model in terms of something with different parameters during times of load. But he left room for interpretation on whether that means they could still use quantization or sparsity. And then additionally, his answer wasn't clear enough to know whether or not they use a lower depth of beam search or other cheaper sampling techniques.

He said the only time you might get a different model itself is when they are A-B testing just before a new announced release.

And I think he clarified this all applied to the webui and not just the API.

(edit: I'm rate limited on hn, here's the source in reply to the below https://www.youtube.com/watch?v=ugvHCXCOmm4&t=42m19s )

avarun · 9 months ago
Source?

u/avarun

KarmaCake day415July 11, 2016
About
Varun Arora, varun [at] varun [dot] codes

[ my public key: https://keybase.io/varunarora; my proof: https://keybase.io/varunarora/sigs/wKOHSwQ2CrIeEblomNw37xlU4pIRclWlhWkPfSoEEE4 ]

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