Readit Newsasafira commented on There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests arstechnica.com/health/20... · Posted by u/voxadam
If you're on TRT, you are already not producing enough on your own.
Isn't there TRT that doesn't impact your endogenous production? (HCG, SERMs)
Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one drug that is so good at so much.
There is large-enough consensus on this drug for its main use cases (treating diabetes and obesity), but more importantly for this conversation: it's actually quite common for drugs to get new indications after their initial one --- at which point, there might be a new, broader consensus on what the drug is good for.
Clinical trials are designed to treat a very specific subclass of individuals; pharmaceutical companies very carefully choose that subclass in an attempt to help ensure the clinical trials are successful, which is a combination of the following:
- Positive, statistically-significant results. - FDA approval with those results. - Insurance companies willing to pay for the given treatment. - A decent-sized addressable market.
Examples of drugs/medical technologies later getting other indications: - Minoxidil was a drug that only later got its approval to be used as a hair loss treatment; there are currently clinical trials for a more "advanced" minoxidil oral pill for this use case. - Re: GLP-1s: Tirzepatide later got an indication that it effectively treats sleep apnea. There are very many other clinical trials ongoing for GLP-1s, but perhaps most recently, Semaglutide (ozempic) failed to show statistical significance as a treatment for Alzheimer's. - The Galleri blood screening/test. The initial indication they are going for is folk who are at highest risk for cancer (I believe that's individuals between the ages of 50 and 70); however, that's not to say it would be bad for individuals younger or older. But, this is a way to help ensure the earliest product has a successful outcome.
These are ones I know off the top of my head, but I suspect an LLM can give several more examples.
Pixel camera hardware or software? Isnt there only one vendor for sensors - Sony?
He worked mostly on the software side, but of course had important input into what sensors and processors were chosen for the phones.
I did my PhD in Atomic, Molecular, and Optical (AMO) physics, and despite "optical" being part of that I realized midway that I didn't know enough about how regular cameras worked!
It didn't take very long to learn, and it turned out to be extremely important in the work I did during the early days at Waymo and later at Motional.
I wanted to pass along this fun video from several years ago that discusses HDR: https://www.youtube.com/watch?v=bkQJdaGGVM8 . It's short and fun, I recommend it to all HN readers.
Separately, if you want a more serious introduction to digital photography, I recommend the lectures by Marc Levoy from his Stanford course: https://www.youtube.com/watch?v=y7HrM-fk_Rc&list=PL8ungNrvUY... . I believe he runs his own group at Adobe now after leading a successful effort at Google making their pixel cameras the best in the industry for a couple of years. (And then everyone more-or-less caught up, just like with most tech improvements in the history of smartphones).
Market opportunity: A USB-stick-shaped device that, when you plug it into a USB-C port, probes the port and lights up LEDs to show the port's capabilities.
[x] 5 Gbps
[x] 10 Gbps
[ ] 20 Gbps
[ ] Power Delivery
[x] DisplayPort Alternate Mode
Even better if it is actually a usb stick, too.
The brand is already tarnished. I know many people that use lyft over Uber for this reason alone.
This might be the silicon valley bubble here though.
asafira commented on Accelerated “Ray Tracing in One Weekend” in CUDA devblogs.nvidia.com/accel... · Posted by u/corysama
Whitted published the first paper applying recursive ray tracing to the problem of rendering an image. Quibbling over this is like saying no one invented compute graphics because Renaissance artists knew how projection worked.
I am sorry you feel that way =/; I understand it was a picky comment, but quibbling over it is far from the gross overstatement you mentioned.
asafira commented on Making rain simulation as real as possible rainbowhunt.me/?plays... · Posted by u/sazers
I've read before that they used to use the sound of bacon cooking on a skillet to mimic the sound of rain in movies. I think I can hear it...
asafira commented on Accelerated “Ray Tracing in One Weekend” in CUDA devblogs.nvidia.com/accel... · Posted by u/corysama
"Ray Tracing in One Weekend" is the first in a very popular 3-part series of short, introductory-level books on ray tracing.
"Ray Tracing in One Weekend/The Next Week/The Rest of Your Life" have recently switched to DRM-free, "Pay What You Want" pricing http://in1weekend.blogspot.com/2016/01/ray-tracing-in-one-we...
From the post: "Ray tracing was invented by Turner Whitted around 1980."
I believe that Turner probably did some great things, but somehow I don't think I believe he invented ray tracing. Ray tracing has been around for so long in physics...