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Gethsemane commented on Meow.camera   meow.camera/... · Posted by u/southwindcg
eknkc · 2 months ago
This seems like a great program!

Small anectode;

My wife runs a cafe in Ankara, Turkey. A week after opening a random cat walked in and claimed one of the chairs.

We started feeding him. Then another walked in... We left a large automated feeder outside and started spaying / neutering, vaccinating, deworming them. I think we neutered close to 20-30 cats. A couple needed medical intervention (broken limbs, infections etc). And 2 I had to put down because they were too far gone. This effort alone put the neighborhood kitten population in control.

The place was aimed at health conscious / vegan people so the theme fit with cats hanging around.

It is really emotionally and financially draining to do these things. I've been fortunate enough to fund everything myself but I assume it is hard when scale grows larger and there is not enough help.

Gethsemane · 2 months ago
A highlight of my time in Turkey was the cats - thank you for your efforts! Antalya had a lot of cat hotels in the park and most looked very healthy.
Gethsemane commented on Apple M5 chip   apple.com/newsroom/2025/1... · Posted by u/mihau
mrkeen · 2 months ago
I have a pretty good time on Asahi Fedora (macbook air M1). It supposedly also supports M2 but no higher.

And it's a PITA to install (needs to be started within macosx, using scripts, with the partitions already in a good state)

Gethsemane · 2 months ago
If I was less lazy I could probably find this answer online, but how do you find the battery life these days? I'd love to make the switch, but that's the only thing holding me back...
Gethsemane commented on OpenZL: An open source format-aware compression framework   engineering.fb.com/2025/1... · Posted by u/terrelln
felixhandte · 3 months ago
It was really hard to resist spilling the beans about OpenZL on this recent HN post about compressing genomic sequence data [0]. It's a great example of the really simple transformations you can perform on data that can unlock significant compression improvements. OpenZL can perform that transformation internally (quite easily with SDDL!).

[0] https://news.ycombinator.com/item?id=45223827

Gethsemane · 3 months ago
I'd love to see some benchmarks for this on some common genomic formats (fa, fq, sam, vcf). Will be doubly interesting to see its applicability to nanopore data - lots of useful data is lost because storing FAST5/POD5 is a pain.

Deleted Comment

Gethsemane commented on Removing newlines in FASTA file increases ZSTD compression ratio by 10x   log.bede.im/2025/09/12/zs... · Posted by u/bede
totalperspectiv · 3 months ago
Removing the wrapping newline from the FASTA/FASTQ convention also dramatically improves parsing perf when you don't have to do as much lookahead to find record ends.
Gethsemane · 3 months ago
Unfortunately, when you write a program that doesn't wrap output FASTAs, you have a bunch of people telling you off because SOME programs (cough bioperl cough) have hard limits on line length :)
Gethsemane commented on Do I not like Ruby anymore? (2024)   sgt.hootr.club/molten-mat... · Posted by u/Vedor
maleldil · 4 months ago
Typer is very convenient. I don't believe anyone manually parses arguments manually in Python where we have argparse in the standard library, and Typer is a step forward from that.
Gethsemane · 4 months ago
I really want to like typer, and frequently go down the rabbit hole of rewriting all my argparse into typer, but I keep getting put off by it's high import cost and that development seems to be a bit up in the air (see https://github.com/fastapi/typer/issues/678#issuecomment-319...). A shame because otherwise it's a really nice library!
Gethsemane commented on AlphaGenome: AI for better understanding the genome   deepmind.google/discover/... · Posted by u/i_love_limes
331c8c71 · 6 months ago
This one seems like well done research but in no way revolutionary. People have been doing similar stuff for a while...
Gethsemane · 6 months ago
Agreed, there’s been some interesting developments in this space recently (e.g. AgroNT). Very excited for it, particularly as genome sequencing gets cheaper and cheaper!

I’d pitch this paper as a very solid demonstration of the approach, and im sure it will lead to some pretty rapid developments (similar to what Rosettafold/alphafold did)

Gethsemane commented on Using Pandoc and Typst to Produce PDFs   imaginarytext.ca/posts/20... · Posted by u/bribri
binarycoffee · a year ago
I can see why someone would prefer Typst over LaTeX when the source is written in Typst or LaTeX, but what are the advantages if your source document is in Markdown? Is there anything else beyond the (presumably) smaller install size of Typst?
Gethsemane · a year ago
Something I found useful is that you can create a much more minimal pandoc template for typst than for latex. Obviously if familiar with latex it probably won't be an issue, but when I tried to make my own barebones pandoc template (i.e., stripping out beamer) I gave up.
Gethsemane commented on Using Pandoc and Typst to Produce PDFs   imaginarytext.ca/posts/20... · Posted by u/bribri
Gethsemane · a year ago
I've similarly found the combination of pandoc + typst to be quite exciting. I've found it particularly useful for typesetting academic papers - I'm quite averse to word in general, don't require extensive mathematical typesetting support, and find latex to generally be quite unapproachable (just look at the size of the default pandoc template!), and so it gives me a method of making a decent pdf whilst simultaneously producing a .docx for my collaborators. Being able to track changes with git is also a huge advantage, although never had the chance to work with someone who is comfortable using git :(

The recently added support for PDF/A is also quite exciting, as I've never found a satisfactory solution to this with latex. Now I just wish journals would support markdown submissions...

Gethsemane commented on Chemists Create World's Thinnest Spaghetti   phys.org/news/2024-11-che... · Posted by u/pseudolus
Gethsemane · a year ago
I am a fan of the colour scheme they selected in figure 2 - very relevant. https://pubs.rsc.org/image/article/2024/na/d4na00601a/d4na00...

u/Gethsemane

KarmaCake day47September 6, 2024View Original