Generally tomatoes and maybe peppers have enough margin and volume to be justify indoor settings.
Things like nuts are a no-go or any sort of wheat/cotton/maize/soybean operation (even specialty applications like edamame have severe uphill battles to profitability)
I'm mulling whether we have enough land (at 100% regen practices). I almost think we do.
From a system-level, we're over saturated because of ethanol and other things that realistically could disappear and society would be better off. Just need to recalibrate our acres a bit