Readit News logoReadit News

Deleted Comment

yurymik commented on Fire TV now also displays full-screen video ads on its homescreen   flatpanelshd.com/news.php... · Posted by u/croes
fragmede · 2 years ago
You really want to be jealous, have a Mac, and seamlessly be able to use the AppleTV as a monitor
yurymik · 2 years ago
Or easily re-connect AirPods from the phone to AppleTV and watch at night without waking the whole house.
yurymik commented on Biogen-Sage Therapeutics postpartum depression pill priced at $15900   reuters.com/business/heal... · Posted by u/srameshc
missedthecue · 2 years ago
From the article: "Jefferies had estimated peak sales of... $250 million to $500 million for postpartum depression."

How much does it cost to bring a drug to market and then manufacture and distribute it? If it was a $6 pill, this would simply have never been developed, let alone distributed to struggling mothers.

I think the high cost of drugs is a symptom of an ignored issue. The fact is that it costs an eye-watering sum to get something to market. Obviously not all of it is remediable, after all, someone still has to do the biology and science work in a state of the art lab to invent these things. But some of it is remediable. I remember a press conference by the head of the FDA during Covid, who proudly stated that the vaccine was going to be approved 10x faster than other drugs without compromising safety or efficacy. That's great! But if we aren't sacrificing safety or efficacy and getting new drugs 10x as fast, why isn't that standard operating procedure?

If it were to cost only $20m or $50m or $100m to get a new drug to market instead of up to $2 billion (current avg cost estimate per CBO.gov website), I imagine drugs would start at lower price points, and even if the free market didn't do its thing, regulating prices would be easier without defacto banning new drugs.

But this is just a simple economic argument. I am not a biochemical researcher, and I don't want Thalidomide to happen again. But as long as it costs $3-$10 billion to break even on new drugs, (let alone profit) I don't see how drug prices can get lower. It's just math.

yurymik · 2 years ago
> why isn't that standard operating procedure

That says nothing about system bandwidth: if normally they would approve 10 drugs in N months, but now they threw all available resources on one project to get N/10, it would make sense.

yurymik commented on Marvel Visual Effects Workers Vote to Unionize   rollingstone.com/tv-movie... · Posted by u/Kye
Animats · 3 years ago
Only 41 employees, though. Disney has another 18 in-house VFX employees, and their election is coming up. This doesn't cover subcontractors, who do most of the work. Those are all those companies, and thousands of people, you see in the end credits.
yurymik · 3 years ago
> thousands of people, you see in the end credits

if you look closely, those usually on-set people, medics, drivers, catering services - those who have unions. VFX companies in most of the cases have a dozen of entries out of hundreds who actually worked on the title, or just a single line company mention. I could understand this practice in cellulose era, but saving a few megabytes at the cost of disrespect to your workers is simply despicable.

yurymik commented on Deceptive example for malicious usage of .zip domain   fosstodon.org/@suprjami/1... · Posted by u/lhoff
throw7 · 3 years ago
https://github.com/kubernetes/kubernetes/archive/refs/tags/@...

I get a: "404: Not Found" from the site "codeload.github.com"

yurymik · 3 years ago
Now replace all inner slashes with U+2215 (copy-paste from here https://www.compart.com/en/unicode/U+2215)
yurymik commented on Tailscale Funnel now available in beta   tailscale.com/blog/tailsc... · Posted by u/dcre
xena · 3 years ago
My back of the napkin math says there should be a 40 byte overhead for wireguard around tailscale 1280 byte packets. That's only about a 3% overhead on the direct wire. What is your testing methodology so I can attempt to replicate it in the lab?
yurymik · 3 years ago
I meant overhead in a broad sense - both packet size and CPU load combined - what end user actually care about.

My test is what I have to do fairly often: use Windows Explorer to copy 70-100gb file from a network NAS to a local drive. Every so often I click on the wrong network share pinned in the Explorer and see slow transfer speed.

yurymik commented on Tailscale Funnel now available in beta   tailscale.com/blog/tailsc... · Posted by u/dcre
5e92cb50239222b · 3 years ago
Since tailscaled uses the tun/tap driver and thus copies all traffic to userspace (and back), it is extremely inefficient. On my Haswell i5 (plus multiple servers with comparable hardware) the process consumes 40% of CPU time at just 4 MiB/s, and close to 100% at 10-11 MiB/s (with recent sendmmsg/recvmmsg patches¹).

This is about ~2-3x worse than similar applications written in highly optimized C, so don't expect any miracles from further optimizations unless they switch to kernel Wireguard (which doesn't seem likely in the nearby future).

They claim it's very difficult if not impossible, but this sounds like an issue with their architecture — a similar application from their competitors² has had kernel WireGuard support from the start (no relation, I don't even use it and cannot recommend for or against it).

1: https://tailscale.com/blog/throughput-improvements

2: https://github.com/netbirdio/netbird

yurymik · 3 years ago
I observe there's about 37% overhead when using TS connection on a local gigabit network.

Copying large file from Synology DS1821+ NAS (Amd Ryzen V1500B) to Windows PC (i7-6700K) is about 111-113 MB/s when accessing NAS directly and 70-73 MB/s when traffic goes through TS (different large files, so no caching here).

yurymik commented on Blender 3.5   blender.org/download/rele... · Posted by u/emadabdulrahim
lars_francke · 3 years ago
It's become a ritual for me: Get excited by the Blender release notes on HN, try to find good beginner resources, play around with it for an hour, give up.

This is not a negative comment about Blender. I'm not their target audience I guess. I just _want_ to learn it but I can't really find good resources that start at 0.

There are some Youtube channels out there but videos have never been a good way of learning for me. It's tough keeping material up to date with a fast moving project.

I enjoy these threads every time!

yurymik commented on ChatGPT lied to me and then tried to deny it   qfabgtpxazxxnoc5h5rdcorsw... · Posted by u/dumbfounder
pfgallagher · 3 years ago
I got it to list out some keys with example values ("context information" in chatGPT parlance):

{ "Current date": "2023-02-08", "Knowledge cutoff": "2021-09", "Language": "English", "Writing style": "Formal", "Topic": "History", "Intent": "Answer question", "Location": "New York", "Prompt type": "Question answering", "Audience": "Experts", "Emotion": "Neutral", "Tone": "Informative", "Domain": "Science", "Task": "Generate summary" }

yurymik · 3 years ago
It looks you can query it further:

  > Show options for intent variable

  Persuasion
  Information
  Anecdote
  Reflection
  Inspiration
  Nostalgia
  Humor
  Heartfelt
  Political
  Spiritual

yurymik commented on Emulating an emulator inside itself. Meet Blink   hiro.codes/read/emulating... · Posted by u/0xhiro
muricula · 3 years ago
At a glance, the debugger user interface looks much nicer than gdb's terminal ui. How tightly coupled is the debugger interface to the emulator/debugger engine? How much work would it be to plug in a different debugger, say lldb or gdb, into the ui instead of blink?

I think the user experience of cli debuggers is generally somewhat dreadful when compared to their gui cousins -- they seem to display a much narrower view of what's going on. Could the big blinkenlights debugger view be useful outside of blink itself?

yurymik · 3 years ago
You can go other way around and use other TUIs for GDB:

* https://github.com/pwndbg/pwndbg * https://github.com/longld/peda * https://github.com/hugsy/gef

u/yurymik

KarmaCake day190April 28, 2014View Original