Which does essentially this but requires no indexing of videos!
Using ChatGPT as a starting point? Sounds really good to me, been there, done that.
You can always check information before believing or acting on it.
However it’s often super difficult to even get started and know what it is that you should be reading more about.
Your ‘friend’ was probably into overdose territory and the Modafinil antagonized the d-amphetamine while also inducing a wakefulness effect.
I really hope your friend realizes how bad this was.
Amphetamine is primarily absorbed through the plasma membranes and not DAT since it’s lipid soluble.
Dopamine does not and thus relies on DAT. By inhibiting DAT (as both amphetamine and Modafinil do), you increase extracellular dopamine.
Next, DAT does not “transport amphetamine around the brain”. It only transports it from the post synaptic cleft into the cell.
Also Modafinil is a much weaker DAT inhibitor than amphetamine itself as far as we know.
Lastly, drugs don’t “antagonize” other drugs. That word is a specific term used for the action on the receptor level.
The dopaminergic effects of Modafinil aren’t well known and are thought to be mild. It’s simply misinformation to claim that modafinil was somehow blocking the effects of amphetamine on the dopamine receptors.
Imagine another physical problem. Simulating a sand grain and how it bounces off other sand grains or lodges against them. If you wanted to simulate a sand mountain, you could use a massive amount of compute and predict the location and behaviour of every single grain.
Or, you could take a bunch of well-known shortcuts and just know that sand sits in a heap at the angle-of-repose. That angle decides how steep the mountain will be. any steeper and it will tumble till it's at that angle.
Suddenly, the computation is dramatically reduced, and you get pretty much the same result.
Where this falls apart is that error accumulates over time and not just for one heap of sand but for many such heaps of sand that also interact with other heaps of sand.
Predicting weather for the next hour is trivial. Aviation runs on the fact that you can forecast fairly accurately into the next hour most of the time.
The difficulty scales superlinearly over time due to the error accumulation over predictions
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