Does it do 3D maps? I can understand that the UX will be terrible even with a lot of progressive enhancements. Does it display text (i.e. news sites)? Then it should by all means work without scripting support, and should display images that would usually be lazy-loaded.
I am also willing to compromise on functionality. If a site offers nice, client-side filters for their 100 products, it is OK if they do not work as long as I can [Ctrl]+[F] to find products.
Another thing to consider is that most users who block sites consciously use a plugin that allows unblocking scrips based on the domain (e.g. NoScript, uBlock, uMatrix). Scripts that enable functionality should be hosted on the same TLD or a CDN. I have no mercy if your site depends on various A/B testing and ad tech scripts to work, but I will gladly allow scripts from the origin host, especially if the functionality I gain is explained well.
At the end of the day, humans are pretty much the only thing that matters.