I once took Ketamine, "fell through the bed" and spent half an hour in a different dimension, peacefully floating above and close to incredibly detailed, dull and dark colored patterns while unable to form language-based thoughts until I suddenly snapped out of it. The music I was listening to (HUSBANDS (Run Along, Son, etc.)) helped a lot and was just incredible, though I am still not sure if I could have had the same great experience with different music.
It was THE single most amazing and out-of-this-world thing I ever experienced and I highly recommend it to everyone.
I don't know if it helped me in any way with my depression though. No hangover. No lasting changes.
I had a similar experience with ketamine listening to different music. It felt almost like I was engulfed in the music, in a very positive and beautiful way. Having experienced opiates, MDMA, 2C-E, 2C-B, LSD, shrooms, and DMT, ketamine is still the experience I am most fond of. I sometimes wonder what certain music would feel like to experience on ketamine.
I experienced severe depression in my teenage years. Towards the end of them, I had this ketamine experience (well, a few sessions, but this one stands out in particular.) My depression has never come back nearly as strong as before (it's been over 10 years.)
2C-E on the other hand sent me to some extremely trippy places. 2C-P is a fascinating one to read about too (though I've never tried it.)