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thanatos_dem commented on Generative Optogenetics   darpa.mil/research/progra... · Posted by u/birriel
milchek · 2 days ago
This was a little over my head so I did some digging of course into the negative or potential harmful effects:

Covert biological manipulation: If cells in specific organisms (including people) are engineered to respond to particular light patterns, then light could be used as a trigger to turn on harmful genes or disrupt normal biology in targeted groups, raising concerns about new classes of biological or “neuro” weapons.

Military and control applications: In combination with existing neurotechnology and optogenetics work (e.g., brain interfaces and neural stimulation), there are concerns about using light‑controlled genetic tools for enhancement, interrogation, or behavior influence in military or intelligence settings.

Ethical and societal risks:

Autonomy, consent, and “mind control” worries: Optogenetics already raises concerns about manipulating brain activity, permanence of genetic changes, informed consent, and vulnerability of specific populations once their cells are engineered to respond to light. GO intensifies this by linking genetic programming directly to external optical signals, which magnifies fears of remote influence or coercive use.

Safety, equity, and regulation: There are unresolved questions about long‑term safety, off‑target effects, error rates in in‑cell DNA/RNA synthesis, and who gets access to beneficial applications versus who is exposed to risk, all in a regulatory landscape that is still catching up with advanced gene and neurotechnologies.

Sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC10730653

https://unidir.org/wp-content/uploads/2025/11/UNIDIR_Neurote...

https://www.asimov.press/p/darpa-neurotech

https://www.bioinformatics.org/forums/forum.php?forum_id=154...

thanatos_dem · 2 days ago
Do you have a source for this? Interested in reading more.

Unless it’s your personal summary, in which case curious what sources you used, or if it’s from an LLM in which case I’ll just ask it myself.

thanatos_dem commented on The web does not need gatekeepers: Cloudflare’s new “signed agents” pitch   positiveblue.substack.com... · Posted by u/positiveblue
xdennis · 4 months ago
There are so many terms in software which are nonsensical (starting with "computer science") which could be fixed.

The problem with changing whitelist to "allowlist" is that it implies that people who use whitelist are racists. You're not just virtue signaling (and confusing my spellchecker) but causing discord.

It would be perfectly fine if people switched to "allowlist" because they think it's a better term, but that's not the reason. They do it because they want to virtue signal or they're afraid of their peers (because they'll be called racists).

Using "allowlist" is actually bad because it gives agitators power and they keep changing more words to get more power.

thanatos_dem · 4 months ago
It’s an interesting time we live in.

I personally don’t assume people who use whitelist are racist, or those who allowlist are virtue signaling.

However, I certainly do assume that people who chastise others for using “whitelist” are virtue signaling, and those who deride people for using “allowlist” are racist.

Both are easily understood and I generally assume good intention from people. Just live and let live.

thanatos_dem commented on The web does not need gatekeepers: Cloudflare’s new “signed agents” pitch   positiveblue.substack.com... · Posted by u/positiveblue
thanatos_dem · 4 months ago
Allowlist is arguably fitting for a list of things which are allowed.
thanatos_dem commented on GitHub was down   githubstatus.com/?t=81273... · Posted by u/patabyte
jtdev · 5 years ago
They’re real enough problems that I’d be violating legal agreements by discussing them here... so no, I won’t be doing that.
thanatos_dem · 5 years ago
Cool, you’ve said all you needed to. You can now safely be ignored by our entire industry as far as I’m concerned.

Enjoy your lack of vertical mobility!

thanatos_dem commented on GitHub was down   githubstatus.com/?t=81273... · Posted by u/patabyte
jtdev · 5 years ago
No. I’ll continue to use my skills to solve real problems and voice my opposition to the groupthink mob.
thanatos_dem · 5 years ago
Out of curiosity, what’s the last “real problem” you solved?
thanatos_dem commented on GitHub was down   githubstatus.com/?t=81273... · Posted by u/patabyte
jtdev · 5 years ago
Glancing at your comment history, I can see that you believe your opinions are edicts and nobody can express differing opinions without you pulling your quasi moralistic hall monitoring trope.

The fact is, tech is now under the influence of the woke mob, and I believe that's objectively bad for tech, the people who work in tech, and the prospect of solving REAL problems with tech.

thanatos_dem · 5 years ago
Then just find a new career maybe? I sure as hell wouldn’t hire you at this point.
thanatos_dem commented on GitHub was down   githubstatus.com/?t=81273... · Posted by u/patabyte
thanatos_dem · 5 years ago
Glancing over your comment history, this seems to be a trend for you; being intentionally abrasive/provocative for no reason. And you get downvoted to oblivion as a result, so I'd hope you understand by now that your comments aren't appreciated.

Obviously you're entitled to your opinion and welcome to share it, but don't be surprised when that begins having repercussions on your career, and don't be surprised when people on this forum in particular don't respond well to it.

HN is focused on technology and business, not so much politics or your personal opposition to making historically oppressed individuals feel more comfortable in tech, a traditionally white & male dominated space. If you're going to make reasoned arguments around why changing the name of a branch has a demonstrable negative impact on your life, please do. If not, this isn't the place to air your grievances with crass and unproductive comments.

Deleted Comment

thanatos_dem commented on Google cancels legacy Google Play Music subscriptions   support.google.com/google... · Posted by u/rdslw
paulcole · 6 years ago
> the moment they allow me to upload my MP3-collection

I would not hold your breath for this. The holdover MP3 collector is such a small minority that no mainstream company is going to consider them from here on out.

> is there any other free service where I could upload my MP3 collection to

If there was, why would you waste your time? Either it's not going to be free or it's going to disappear.

thanatos_dem · 6 years ago
That was my Google Play Music use case as well. About a year ago I set up a plex server on my NAS and bulk downloaded my GPM library onto it (which to google’s credit was easy to do). Now I have them on my own hardware, and accessible on the go with the Plex app. It’s a better experience for video than audio, but it’s totally serviceable.

There had been murmurs for a long time of Google Play Music going away, so I moved off ASAP. Looks like that was a good call.

u/thanatos_dem

KarmaCake day970July 29, 2016View Original