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suzumer commented on The Halting Problem is a terrible example of NP-Harder   buttondown.com/hillelwayn... · Posted by u/BerislavLopac
zahlman · 4 months ago
If NP-hard isn't even a subset of NP, why is it called "NP-hard"?
suzumer · 4 months ago
Because a language being NP-hard implies it is at least as hard as the hardest NP problems. For any language that is NP-hard, if one had a turing machine that decided the language, one could construct a polynomial time transformation of any language in NP to the NP-hard language to decide it using the NP-hard turing machine.
suzumer commented on World-first experimental cancer treatment paves way for clinical trial   wehi.edu.au/news/world-fi... · Posted by u/femto
adamredwoods · 6 months ago
Sequentially? Yes. Simultaneously? Rare. Doxorubicin and cisplatin, has been done, but keytruda was quite interesting when it started to do clinical trials in combination with various chemos so that the FDA would approve it. My late-wife's oncologist was hesitant on combining anything, but I kept pushing for pembro plus anything.

But this was also systemically applied, these new ADCs are targeted, much stronger with combination payloads. Sadly, not as effective for harsher cancers like triple-negative BC.

suzumer · 6 months ago
This doesn't track my experience. I have Ewing's Sarcoma, and my first regimen involved 5 agents: Doxorubicin, Vincristine, Cytoxan, Ifofsfomide, and Etoposide. This [1] appears to be the same plan I used. When that failed, I had a second regimen with Vincristine, Irinotecan, and Temozolomide. After that failed, I had Irinotecan and Trabectidin, followed by Doxil, followed by, Cytoxan and Topotecan, followed by high dose Ifofsfomide. So only two of the treatments I received were single agent, but maybe it depends on the cancer.

[1] https://www.cancerresearchuk.org/about-cancer/treatment/drug...

suzumer commented on World-first experimental cancer treatment paves way for clinical trial   wehi.edu.au/news/world-fi... · Posted by u/femto
adamredwoods · 6 months ago
It's triple therapy, which most doctors won't do, which I think is one of the future steps to stopping cancer. We should have been looking at combination therapy a long time ago. Hopefully this will get oncologists to push the envelope a bit more.
suzumer · 6 months ago
I thought using multiple therapies for cancer was fairly common, or are you referring specifically to immunotherapies?
suzumer commented on Using the most unhinged AVX-512 instruction to make fastest phrase search algo   gab-menezes.github.io/202... · Posted by u/cmcollier
fuhsnn · 7 months ago
Do they cover anything Sapphire Rapids Xeon's don't? I thought they share the same arch (Golden Cove).
suzumer · 7 months ago
According to this [1] wikipedia article, the only feature Sapphire Rapids doesn't support is VP2INTERSECT.

[1]:https://en.wikipedia.org/wiki/Advanced_Vector_Extensions

suzumer commented on CIA now favors lab leak theory to explain Covid's origins   nytimes.com/2025/01/25/us... · Posted by u/doctaj
wongarsu · 7 months ago
There was also no evidence against it. If there is neither solid evidence for nor against something I find it perfectly reasonable to apply the balance of probabilities. At least as long as you qualify your statement with a "probably".

And with the main competing theory (covid spreading from a wet market in a city that contains a biolab) also being consistent with the hypothesis that it was an accidental lab leak, to me the balance of probabilities always seemed to favor the lab leak hypothesis.

Yet saying that Covid probably originated from a lab leak was once branded as dangerous misinformation, with seemingly no evidence to support that claim

suzumer · 7 months ago
At the time, there was essentially a 50/50 chance it was a lab leak or from a wet market. The issue with saying it was a lab leak at that time is that you are essentially gambling the US's relationship with China should it come out that it was a from a wet market. Also, a lot of the discussion regarding the lab leak theory early on seemed to me like it wouldn't be sated even if the US presented sufficient evidence that it was from a wet market.
suzumer commented on CIA now favors lab leak theory to explain Covid's origins   nytimes.com/2025/01/25/us... · Posted by u/doctaj
ajsnigrutin · 7 months ago
Wasn't this one of those "forbidden" conspiracy theories, censored from most social media, while most people (here too) cheered for "fighting misinformation" with censorship?
suzumer · 7 months ago
Saying COVID-19 leaked from a lab with zero evidence is different than waiting for evidence and then saying it leaked from a lab.
suzumer commented on I algorithmically donated $5000 to Open Source   kvinogradov.com/algo-spon... · Posted by u/lorey
reaperman · 9 months ago
Which is why spotify should pay a percentage of MY subscription fee to only the artists that I listen to. My money shouldn’t go to Taylor Swift if I don’t listen to Taylor Swift.

That would eliminate direct financial payment from botting. But botting could still affect trending or “related” recommendations for indirect financial boost.

suzumer · 9 months ago
The issue there is that the listens from people who listen to less music would be worth more than the listens from people who listen to more music.
suzumer commented on Pretty.c   github.com/aartaka/pretty... · Posted by u/synergy20
nneonneo · 10 months ago
It claims to be a scripting language but you still have to compile the programs. Boo! Add CINT (https://root.cern.ch/root/html534/guides/users-guide/CINT.ht...) and you can have instantaneous execution and even a REPL!
suzumer · 10 months ago
suzumer commented on sRGB Gamut Clipping (2021)   bottosson.github.io/posts... · Posted by u/Brajeshwar
Sesse__ · a year ago
> The article, and Oklab, is not by a color scientist. He is/was a video game developer taking some time between jobs to do something on a lark.

As a non-color scientist sometimes dealing with color, it would probably be nice if the color scientists came out sometimes and wrote articles that as readable as what Ottosson produces. You can say CIECAM16 is the solution as much you want, but just looking at the CIECAM02 page on Wikipedia makes my brain hurt (how do I use any of this for anything? The correlate for chroma is t^0.9 sqrt(1/100) J (1.64 - 0.29^n)^0.73, where J comes from some Chtulhu formula?). It's hard enough to try to explain gamma to people writing image scaling code, there's no way ordinary developers can understand all of this until it becomes more easily available somehow. :-) Oklab, OTOH, I can actually relate to and understand, so guess which one I'd pick.

suzumer · a year ago
Mark Fairchild, one of the authors of CIECAM02, recently published a paper that heavily simplified that equation: https://markfairchild.org/PDFs/PAP45.pdf

If the link doesn't work, the paper is called: Brightness, lightness, colorfulness, and chroma in CIECAM02 and CAM16.

Also, if you want a readable introduction to color science, you can check out his book Color Appearance Models.

suzumer commented on sRGB Gamut Clipping (2021)   bottosson.github.io/posts... · Posted by u/Brajeshwar
suzumer · a year ago
I haven't gone through the whole article, but it seems to be conflating chroma and saturation. If lightness of a color is scaled by a factor c, then chroma needs to be scaled by that same factor, or saturation won't be preserved, and the color will appear more vibrant then it should.

u/suzumer

KarmaCake day204August 6, 2020View Original