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shepardrtc commented on The effect of shingles vaccination at different stages of dementia   cell.com/cell/fulltext/S0... · Posted by u/Archelaos
John7878781 · 11 days ago
> But the first clinical trial to test that theory has found that a common antiviral for herpes simplex infections, valacyclovir, does not change the course of the disease for patients in the early stages of Alzheimer's.

https://www.cuimc.columbia.edu/news/antiviral-treatment-fail...

shepardrtc · 11 days ago
Yeah they looked at 120 people age 71 and above for that study. By that point its a little late.
shepardrtc commented on The effect of shingles vaccination at different stages of dementia   cell.com/cell/fulltext/S0... · Posted by u/Archelaos
jvanderbot · 11 days ago
I'm not skilled, but it feels like a validation for the virus theory of dementia

https://med.stanford.edu/news/all-news/2025/03/shingles-vacc...

"The remarkable findings, published April 2 in Nature, support an emerging theory that viruses that affect the nervous system can increase the risk of dementia. If further confirmed, the new findings suggest that a preventive intervention for dementia is already close at hand."

shepardrtc · 11 days ago
Taking valacyclovir should help prevent or delay as well.
shepardrtc commented on Everyone in Seattle hates AI   jonready.com/blog/posts/e... · Posted by u/mips_avatar
ozfive · 12 days ago
The layoffs are due to tax incentives in the tax cut bills that financially incentivize offshoring work.
shepardrtc · 12 days ago
That makes sense. And its even worse of a reason. At least for people living in the US.
shepardrtc commented on Everyone in Seattle hates AI   jonready.com/blog/posts/e... · Posted by u/mips_avatar
shepardrtc · 13 days ago
Ok so a few thoughts as a former Seattleite:

1. You were a therapy session for her. Her negativity was about the layoffs.

2. FAANG companies dramatically overhired for years and are using AI as an excuse for layoffs.

3. AI scene in Seattle is pretty good, but as with everywhere else was/is a victim of the AI hype. I see estimates of the hype being dead in a year. AI won't be dead, but throwing money at the whatever Uber-for-pets-AI-ly idea pops up won't happen.

4. I don't think people hate AI, they hate the hype.

Anyways, your app actually does sound interesting so I signed up for it.

shepardrtc commented on API that auto-routes to the cheapest AI provider (OpenAI/Anthropic/Gemini)   tokensaver.org/... · Posted by u/h2o_wine
shepardrtc · 20 days ago
For input,

- GPT-5.1 is $1.25 / 1M tokens

- You are $0.50 / 1,000 tokens

Output:

- GPT-5.1 is $10.00 / 1M tokens

- You are $1.50 / 1,000 tokens

Am I reading that wrong? Is that a typo?

shepardrtc commented on Prozac 'no better than placebo' for treating children with depression, experts   theguardian.com/society/2... · Posted by u/pseudolus
techietim · 25 days ago
> my 7-year-old son just started half that dose

This is horrifying.

shepardrtc · 25 days ago
I had terrible anxiety as a child and what I experienced dramatically affected the core of who I am. It is engrained in me and I struggle with it daily, though after decades I have surpassed a good portion of it. If a small dose can help someone have a somewhat "normal" childhood, then its worth a try.

Deleted Comment

shepardrtc commented on Inside Amazon's engineering culture: Lessons from their senior principals   olshansky.substack.com/p/... · Posted by u/Olshansky
speff · 2 months ago
If you know people affected, then you have more information than me and I'm not going to pretend like I have a better grasp on the situation than you.

However, the "last resort" comment I made was a guess to their reasoning - it wasn't an authoritative explanation. My core point is that Amazon seems to think they can do the same, or about the same, or an acceptable amount less with fewer people. If that's the case, then from their perspective, they're overpaying on labor. That's it.

shepardrtc · 2 months ago
I think you're missing a more human point: people dislike the effect of hiring and firing thousands of people with zero consideration. They hire thousands because it makes management look like they're ramping up to solve problems, and then they fire this many people because it makes management look like they're cutting costs to be more efficient. It's all about management keeping up the illusion that they're "on top of things", when in reality they're just playing number games.

There's empathy involved in the revulsion toward this kind of process. Please take time to consider that not everyone fired is a $300k/year rockstar programmer who can just as easily walk over to Meta or Google for a job. I know of people who have uprooted their lives and work under the idea that if they do a good job they'll stay on, when in fact the reality is more like gambling and they could be fired at any point.

shepardrtc commented on Inside Amazon's engineering culture: Lessons from their senior principals   olshansky.substack.com/p/... · Posted by u/Olshansky
whatever1 · 2 months ago
Hi, people are not widgets.

They take huge personal, family and financial risks to move for a job. When you are getting rid en-masse people, you are ruining local communities. There is a real societal cost.

It also sucks for businesses, because hiring & onboarding is so freaking hard and expensive. Not to mention that once the company has established a reputation of a revolving door, then nobody gives a shit about it. They will exploit it for the short term and let it die.

Layoffs should the absolute last resort for a company due to the disruption they cause. If the market dynamics do not naturally lead to this, then regulation should shape the field.

shepardrtc · 2 months ago
I pulled myself from a recent Amazon interview process because of how bad they are. At first I had the opinion that this could be interesting and exciting, but the more I thought about how they treated people, the more I realized that the internal culture must be terrible. And honestly I just don't need to be involved with any of that.
shepardrtc commented on Karpathy on DeepSeek-OCR paper: Are pixels better inputs to LLMs than text?   twitter.com/karpathy/stat... · Posted by u/JnBrymn
almoehi · 2 months ago
I’ve had written up a proposal for a research grant to basically work exactly on this idea.

It got reviewed by 2 ML scientists and one neuroscientist.

Got totally slammed (and thus rejected) by the ML scientists due to „lack of practical application“ and highly endorsed by the neuroscientist.

There’s so much unused potential in interdisciplinary research but nobody wants to fund it because it doesn’t „fit“ into one of the boxes.

shepardrtc · 2 months ago
Sounds like those ML "scientists" were actually just engineers.

u/shepardrtc

KarmaCake day2247May 11, 2014View Original