If we fixed it, nobody would get gout.
I kinda wonder sometimes why medicine doesn't try to fix some of these species level genetic problems more broadly or more quickly. There's this enzyme every other mammal produces, why isn't there a fast track to engineering a micro-organ to produce it or inject an engineered version in gout patients (I did some research and yes people are somewhat doing these things... slowly)
Why can't I, a healthy adult, be genetically engineered to start producing my own Vitamin C like every other mammal?
I wish you all the luck in fixing these problems and would be fascinated to see the outcomes… However, this notion that these changes would be cost free is a mistaken one.
Mutants with these characteristics have certainly existed over evolutionary time… Our version outcompeted them.
1. The power button is in an awkward location, meaning rackmounting them (either 10" or 19" rack) is a bit cumbersome (at best)
2. Thunderbolt is great for peripherals, but as a semi-permanent interconnect, I have worries over the port's physical stability... wish they made a Mac with QSFP :)
3. Cabling will be important, as I've had tons of issues with TB4 and TB5 devices with anything but the most expensive Cable Matters and Apple cables I've tested (and even then...)
4. macOS remote management is not nearly as efficient as Linux, at least if you're using open source / built-in tooling
To that last point, I've been trying to figure out a way to, for example, upgrade to macOS 26.2 from 26.1 remotely, without a GUI, but it looks like you _have_ to use something like Screen Sharing or an IP KVM to log into the UI, to click the right buttons to initiate the upgrade.
Trying "sudo softwareupdate -i -a" will install minor updates, but not full OS upgrades, at least AFAICT.
Thunderbolt as a server interconnect displeases me aesthetically but my conclusion is the opposite of yours:
If the systems are locked into place as servers in a rack the movements and stresses on the cable are much lower than when it is used as a peripheral interconnect for a desktop or laptop, yes ?