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rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
dur-randir · 7 months ago
Shitty shits. Literally. As for metabolic acidoses, rates are extremely low (<10 cases per 100,000 patient-years, per https://pubmed.ncbi.nlm.nih.gov/26773926/), so it's almost a non-concern.
rscho · 7 months ago
~1/10.000 patient-years is a non-concern ?! I hope you're not an epidemiologist.
rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
the__alchemist · 7 months ago
What side effects cause people taking Metformin to discontinue it? I'm taking, but haven't noticed any, but... you don't notice your baseline, I suppose!
rscho · 7 months ago
Metabolic acidosis. Not trivial at all.
rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
gautamcgoel · 7 months ago
Simple solution: take an antacid, like Tums.
rscho · 7 months ago
Which happily, is totally devoid of side effects.
rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
ac29 · 7 months ago
> Be careful when reading such blogs

I followed a link to another blog post of theirs in which they go on a rant claiming there was a conspiracy to suppress chloroquine and ivermectin as COVID treatments. I dont think anyone should be taking health advice from this person

rscho · 7 months ago
Amusingly, this was a very common if not the most common stance on this very website some time ago. Surely, don't look for assistance on the internet regarding memory issues.
rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
obloid · 7 months ago
I recently saw a patient with overwhelming MRSA sepsis with multiple foci of infection including epidural abscess (around the spinal cord), and meningitis. This person was taking rapamycin presumably for "life extension" purposes. Almost certainly the immunosuppression from the rapamycin made the infection much worse.

I'd be very wary of taking an immunosuppressive drug as an otherwise healthy person for theoretical life extension properties.

rscho · 7 months ago
Don't come and spoil our nice individualism with populational effects, you filthy rationalist !
rscho commented on Endoscopist deskilling risk after exposure to AI in colonoscopy   thelancet.com/journals/la... · Posted by u/smartmic
rscho · 7 months ago
Of course deskilling will happen. But marketing says the machine is more often right than the operator is, and people also want it (we can replace docs with AI today, yadda yadda). Soooo... to be expected? It's just that the machine has to work correctly, which is not on the endoscopist, right?
rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
standardUser · 7 months ago
Vodka Red Bull is not a cocktail it is a drug.
rscho · 7 months ago
You're absolutely right! This man's got horrible taste in drugs.
rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
adamgordonbell · 7 months ago
Also this:

> The best reason to take multiple life extension supplements is to hedge our bets, because we really don’t know which of them are effective in humans.

And earlier:

> Personally, I take large doses of rapamycin 2 days a week, 8 weeks per year. For personalized recommendations, you can consult your favorite life extension doc.

rscho · 7 months ago
How to hedge a bet 101:

1.you bet on risky stuff using something of value (money, health,...)

2.since you're unsure whether your bet will pay off, you bet some more on some other risky stuff, just to be sure.

BTW if you were wondering, of course all those proposed weird life-prolonging treatments are totally devoid of side-effects.

rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
Etheryte · 7 months ago
It works for the majority of modern medicine, so it's not all that black and white.
rscho · 7 months ago
Yes, although even for modern medicine curative and preventative strategies are very distinct. Sure, they'll give you pills to compensate for a problem you already have. But there are few meds that protect you against stuff you'll maybe catch in the future. Vaccines and antibiotics are obvious examples, but I'm not aware of many others. The rest of preventative strategies overwhelmingly consists in correcting deficits or excesses (calories, vitamins, sleep, exercise etc.)
rscho commented on Review of Anti-Aging Drugs   scienceblog.com/joshmitte... · Posted by u/XzetaU8
rscho · 7 months ago
You've got horrible taste in cocktails.

u/rscho

KarmaCake day3542December 4, 2016View Original