1. Some systems do not support replication out of the box. Sure your cassandra cluster and mysql can do master slave replication, but lots of systems cannot.
2. Your life becomes much harder with NVME storage in cloud as you need to respect maintenance intervals and cloud initiated drains. If you do not hook into those system and drain your data to a different node, the data goes poof. Separating storage from compute allows the cloud operator to drain and move around compute as needed and since the data is independent from the compute — and the cloud operator manages that data system and draining for that system as well — the operator can manage workload placements without the customer needing to be involved.
Replicated network-attached storage that presents a "local" filesystem API is a powerful way to create durability in a system that doesn't build it in like we have.
If you miss a termination event you miss your chance to copy that data elsewhere. Of course, if you're _always_ copying the data elsewhere, you can rest easy.