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raydiatian commented on Ketamine's effect on depression may hinge on hope   med.stanford.edu/news/all... · Posted by u/cpncrunch
Aurornis · 2 years ago
> I am worried that a lot of the drug-depression research is overlooking an important possibility: that the thing about ketamine/psilocybin/etc that is helping with depression is not some latent property of the molecule, but rather the actual transcendent experience of the trip.

Ketamine dosed at levels used in a lot of the original depression studies won’t result in anything resembling a “trip”. Many of the more responsible clinics will carefully administer IV ketamine infusions over 40 minute (IIRC) spans at levels that only result in a little dizziness.

The association between ketamine depression therapy and “tripping” is a more recent development, pushed partially by clinics and influencers seizing on the trend in the most dramatic way possible. Some of the clinics will now dose people with excessively high doses with the goal of inducing trips and overt experiences, even though this isn’t supported by the literature.

I’m actually growing concerned that the pop-culture obsession with tripping and the over zealousness of ketamine providers is going to result in regulatory crackdown on the whole process.

A few months ago I was discussing the topic with a psychiatrist friend. She had tried prescribing ketamine for several patients, optimistically. However, a number of them complained that it wasn’t enough because they weren’t having full on hallucinations like they had read about online or in books. Several of them also started trying to demand higher and very early refills, despite her explaining up front that she was only willing to follow the dosing protocols used in studies.

raydiatian · 2 years ago
> at levels that only result in a little dizziness.

Anecdotal first hand account, I would have to completely disagree with you. I tried intravenous ketamine therapy about a year ago. I’m plenty experienced with psychoactives, having experienced several at varying doses, so I knew what I was in for. My IVKT experience was a full on trip, definitely not just passive dizziness.

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raydiatian commented on The British Mosquito once carried Niels Bohr in its bomb bay   thedrive.com/the-war-zone... · Posted by u/pepys
raydiatian · 2 years ago
It certainly would have been interesting if Bohr had been found dead upon arrival because his oxygen mask wasn’t properly handled.

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raydiatian commented on Jupe: Off-grid shelters that pop up anywhere on Earth   jupe.com/get-jupe... · Posted by u/pr337h4m
raydiatian · 2 years ago
Good to know there are products targeted at exclusively the ultra wealthy. Was worried that with all of the calls for them to pay their fair share of taxes that the markets for them would dry up. /s
raydiatian commented on Anti-Anti-Adblocker uBlock filter to get rid of the annoying YouTube message   twitter.com/endermanch/st... · Posted by u/the_bookmaker
lemoncookiechip · 2 years ago
Gorhill (uBO's developer) is in the comment section urging people to not use these types of unverified fixes: https://x.com/gorhill/status/1713305785659211991
raydiatian commented on Humid Heat Can Kill Us Much Faster Than We Thought   nautil.us/humid-heat-can-... · Posted by u/Brajeshwar
darthrupert · 2 years ago
Saunas are somehow different, because their effect for health is entirely positive. Dry and wet.

Many Finns sit in wet saunas at 70-100C for 10-30 minutes every week.

raydiatian · 2 years ago
100C? Where we boil water? ;)
raydiatian commented on Microsoft SEC 8-K: IRS is seeking an additional tax payment of $29B   microsoft.gcs-web.com/nod... · Posted by u/raimue
andrewstuart · 2 years ago
Yea hello it’s Mr Smith here from the tax department. I’ve just been reviewing your file and it seems that you are a little short in your tax payments by…… let’s seeeee ……. ummmm …… yes, $29,000,000,000. Can you pay it now please?
raydiatian · 2 years ago
Yes we kindly accept iTunes gift cards.
raydiatian commented on Movie piracy is strongly linked to box office revenue   torrentfreak.com/movie-pi... · Posted by u/isaacfrond
crazygringo · 2 years ago
I think it has limited truth.

Everyone I know who used to pirate music, now just subscribes to Spotify or whatever. So definitely not the case there.

On the other hand, not one person I know who used to pirate Photoshop, has ever then personally paid for it once they started making money. (Their employer often did, though.)

Movies/TV are somewhere in the middle. I think a lot of people pirate because the content they want to watch is spread out among so many services that need separate subscriptions. You can't pay for all of them all the time when you go for months without touching some of them, but constantly canceling and resubscribing is madness.

Also dealing with the nonsense that Netflix won't display high-quality resolution on all external displays, etc.

raydiatian · 2 years ago
> Everyone I know who used to pirate music, now just subscribes to Spotify or whatever. So definitely not the case there.

Sure, people can ascend through income classes, but there’s always a new cohort of broke young people. I imagine young adults today are pirating plenty as well.

u/raydiatian

KarmaCake day837March 8, 2022View Original