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pitdicker commented on The efficacy of duct tape vs. cryotherapy in the treatment of the common wart (2002)   pubmed.ncbi.nlm.nih.gov/1... · Posted by u/nixass
pitdicker · a year ago
As it was explained to me warts are caused by a virus, which at some point the local skin tissue no longer attacks. Any treatment that provokes the immune system in the area without damaging the tissue too much has a change of waking up the immune system to the wart's virus.

If that is true it is no surprise to me all sorts of folk medicine work on warts.

pitdicker commented on It's not your age that's slowing your metabolism, new research says (2021)   cnn.com/2021/09/24/health... · Posted by u/paulpauper
paulpauper · a year ago
I don't think it's a s simple as inactivity. IF this were true, then being active would reverse the weight gains, but it does not, at least not for me and others. I was still as active in my 30s as I was in my late teens and 20s but still gained weight. Likewise, gyms are full of people in their 30s and 40s who are not losing weight despite regular attendance. Despite the popularity of fitness apps, people keep getting fatter. It is only GLP-1 drugs that has put some dent in obesity rates. I think metabolism or some other biological, non-environmental variable plays some role. Or some reduction of NEAT that cannot be explained by careers.
pitdicker · a year ago
On average man burns ca. 2500 kcal per day, mostly in rest. One hour of reasonably intensive cardio burns 500~600 kcal. If you have two such workouts a week it comes down to an increased energy use of 2*600/(7*2500) = 7%. Or a large meal. Just looking at the numbers it seems spending some time at the gym is not going to do much for loosing weight. Or said differently: eating 7% less is easier.

Of course cardio and strength training are useful for building/preserving muscle mass and general fitness. But for weight loss looking at food seems more effective.

pitdicker commented on Fair Cake-Cutting   en.wikipedia.org/wiki/Fai... · Posted by u/RetroTechie
pitdicker · 2 years ago
When it comes to economics it never ceases to amaze me that we build an entire system on the basic assumption that everyone acts primarily in their own self-interest, and that that system somewhat manages to function.

Luckily when it comes to regular cake cutting there may be a host involved that just wants to give his guests something nice. And the guests hopefully just enjoy the cake instead of being overly sensitive about the fairness of the divisions.

pitdicker commented on Some fish live beyond 100 and get healthier as they age   nationalgeographic.com/pr... · Posted by u/prmph
bestouff · 2 years ago
> In one study, bigmouth buffalo had stronger immune systems than younger fish.

Or maybe only fishes with a stronger immune system get older ?

pitdicker · 2 years ago
Or something changed in the environment that made younger fish less healthy.
pitdicker commented on How the placenta evolved from an ancient virus (2020)   whyy.org/segments/the-pla... · Posted by u/bkudria
pitdicker · 2 years ago
> The syncytiotrophoblast is the outermost layer of the placenta, the part that is pressed against the uterus. It’s literally a layer of cells that have fused together, forming a wall. ... There’s no other structure like this anywhere else in the body.”

> When evolutionary biologists like Chuong mapped the genomes of these cells, they found that the protein that allowed these cells to fuse into a wall, called syncytin, didn’t look like it came from human DNA. It looked more like HIV.

So the entire premise of the placenta evolving from a virus rests on the fact that the organ has a unique function requiring a unique protein in the body. Saying the source probably is a virus seems quite a leap of thought. And aren't there many highly specialized proteins in the body?

Has anybody has some more information on what protein in a retrovirus looks similar to syncytin?

pitdicker · 2 years ago
Paper that discusses similarities between the envelope glycoprotein of retroviruses and syncytin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758191/

This field is called paleovirology, and the paper also discusses in some more detail how fragments of viral DNA can end up in human DNA.

pitdicker commented on How the placenta evolved from an ancient virus (2020)   whyy.org/segments/the-pla... · Posted by u/bkudria
pitdicker · 2 years ago
> The syncytiotrophoblast is the outermost layer of the placenta, the part that is pressed against the uterus. It’s literally a layer of cells that have fused together, forming a wall. ... There’s no other structure like this anywhere else in the body.”

> When evolutionary biologists like Chuong mapped the genomes of these cells, they found that the protein that allowed these cells to fuse into a wall, called syncytin, didn’t look like it came from human DNA. It looked more like HIV.

So the entire premise of the placenta evolving from a virus rests on the fact that the organ has a unique function requiring a unique protein in the body. Saying the source probably is a virus seems quite a leap of thought. And aren't there many highly specialized proteins in the body?

Has anybody has some more information on what protein in a retrovirus looks similar to syncytin?

pitdicker commented on Show HN: Htmldocs – Typeset and generate pdfs with HTML/CSS   htmldocs.com... · Posted by u/kelvinzhang
pitdicker · 2 years ago
Prince has been doing this for 20 years and is in my opinion the gold standard, with good support for footnotes, endnotes, page headers and other little extensions that are only relevant for printing. https://www.princexml.com/

But I'll be giving this a try!

pitdicker commented on We need technology that is less immersive, not more   filiph.net/text/we-need-t... · Posted by u/filiph
haswell · 2 years ago
While sitting with my iPad typing the other morning, something about the experience struck me in a way that it never had before.

I've been typing since the early 90s, and can type around 120WPM without looking or thinking about it, and it hit me that in a very real sense, the iPad (and other computing devices) are already an extension of me. I've invested the time to integrate this hardware into my brain via the keyboard interface, and once typing is automatic, the friction between brain and machine is very low. I can transmit information from brain to computer and back relatively quickly.

The thing about immersive tech is that we're already immersed in tech. The next generation of VR/AR promises to immerse us even more, but I think it's interesting to consider the idea that we're already immersed and don't always realize it.

When you start to look at the space around you as an extension of you (and I think there are good reasons to look at it this way - your immediate surroundings are in effect a projection/construct formulated by your brain, and the actions you take within that space modulate your average conscious experience), and when you start to look at the computing devices around you as part of that extension of you, it starts to raise really interesting questions like:

If I could implant a chip in my brain, and if people could control my brain with that chip, I would probably never allow it. But when that chip is outside of my brain in a device I keep in my pocket, why am I more willing to allow other entities to feed me stimuli?

I tend to agree with the broader idea that we need to be less immersed in tech, if for no other reason to reduce this kind of external control mechanism we've all hooked ourselves in to. And I don't think immersion is limited to the obvious developments like that next generation VR/AR headset. Immersion is already extremely high.

pitdicker · 2 years ago
If wish we could merge this comment with the thread where people are defending Youtubes right to show ads. I am so glad there is technology available to choose what I want to read and see without being forced too much other content.
pitdicker commented on What has a 1 in a million chance? (2010)   stat.berkeley.edu/~aldous... · Posted by u/ksec
sd9 · 2 years ago
> The chance for a CC2 building (apartment buildings, offices, hotels etc.) is defined as moderate with 0.03

Does this mean 3% or 0.03%?

pitdicker · 2 years ago
If a CC2 building collapses, the expectation is that in only about 3% of the cases this leads to someone dying. I don't know the complete reasoning, but can imagine some factors of why this number is far below 100%: a building is not always in use, there are often warning signs with time to escape, and collapse can be localized (not the whole building).
pitdicker commented on What has a 1 in a million chance? (2010)   stat.berkeley.edu/~aldous... · Posted by u/ksec
pitdicker · 2 years ago
It may be nice to know the safety factors used for structural engineering of homes, offices and other regular buildings in the EU.

The Eurocode defines 3 consequence classes: CC1, CC2 and CC3. CC1 has the lowest consequence and is used for regular homes, light industry and agriculture. The chance of dying as a result of structural failure is low, 0.001. The chance for a CC2 building (apartment buildings, offices, hotels etc.) is defined as moderate with 0.03. And CC3 is for special buildings, such as large stadiums, with a high risk of death on structural failure, 0.3. There are other factors that go in defining a consequence class however, including economic and social concerns.

The consequence class maps to the chance that we find it acceptable for a building to collapse in a given year. Causes can be anything, like extreme weather. For CC1 this is 1 in 100, for CC2 1 in 10.000, for CC3 a chance of 1 in 100.000.

So the chance one or more people die in a stadium during a heavy storm due to structural failure could be 1 in 300.000 in a year if you purely look at the statistics behind the structural safety standard.

The statistics map to simple reference values for the loads of wind, snow, rain, usage etc. and easy safety factors. For example CC2 has a safety factor of 1,5 over all variable loads.

u/pitdicker

KarmaCake day265December 11, 2016View Original