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nwienert commented on GLM5 Released on Z.ai Platform   chat.z.ai/... · Posted by u/CuriouslyC
miohtama · 9 hours ago
In some ways, Opus 4.6 is a step backwards due to massively higher token consumption.
nwienert · 8 hours ago
For me, it's just plain worse.
nwienert commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
wincy · a day ago
My wife has had an autoimmune disease that’s caused inflammation for years. Absolutely terrible back pain. She had to rent a motorized scooter when we went to Disney World, and could barely walk a few hundred feet before having to stop and rest for years.

Last year she started Zepbound (tirzepatide) and the inflammation went away, we went to Disney World again and she walked happily all day. Absolutely life changing. She didn’t even lose much weight and this was at the lowest dose.

nwienert · a day ago
Tirzepatide specifically seems especially beneficial, likewise here. Years of slowly increasing symptoms since I was young, lifelong annoying issues, basically all gone on it. And also not overweight at all, I take below lowest dose and skip most weeks now that it's under control.
nwienert commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
mhurron · a day ago
> A drug that cures obesity and addiction alone would be a wonder drug.

A drug that influences a hormone causing effects on everything that hormone is involved in shouldn't be considered a wonder drug, it should be expected functionality.

It's only a wonder drug that does all these miraculous things if you think GLP-1 is only a weight management hormone. It's not, and you should expect effects anywhere it is involved in. A short list of tissues we know GLP-1 is involved in processes is:

- heart - tongue - adipose tissue - muscles - bones - kidneys - liver - lungs

Effects on these aren't miracles, they should be expected.

I am happy to hear you saw so many improvements, but it's because you had an issue with a hormone that is involved in a lot of things in the body. So it was going to express a lot of problems. It's not surprising that you see a lot of improvements when you begin to manage the underlying cause.

nwienert · a day ago
The fact you assume to know what my issue is is wild, and especially since you're just completely wrong - I have no direct GLP-1 issue, my levels are normal.

It's clear you have no idea what you're talking about. Every single case I'm talking about outside weight loss has nothing to do with having a deficiency of that hormone, rather it's fixed by the hormone raising. And given it was impossible to do otherwise, it's a wonder drug, of course. You don't really define wonder by how simple it is, but by the effects, which are tremendously beneficial to many.

Further, I stand by my prediction that in the long run the vast majority of why this drug will be considered an once-a-generation discovery, is not due to weight loss or appetite control, but in fact it's seeming broad spectrum benefits across many systems. And actually your list of effects it has are interesting, because if you investigate deeply the studies published, you'll find that the results are overwhelmingly positive - brain, heart, many organs.

nwienert commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
mhurron · a day ago
> Seems like a wonder drug to me

Not really, it's that hormones don't do just one thing in the body. GLP-1 isn't just some weight management hormone.

> The one that stuck with me from a few weeks ago went like 'I puked up my own poop.'

That happens if you let constipation go on far too long, and is not something unique to GLP-1 meds.

nwienert · a day ago
> Not really

This made me actually laugh. A drug that cures obesity and addiction alone would be a wonder drug.

This one also improves about a hundred odd immune disorders, including being a better general allergy drug than just about anything. My own extremely rare and terribly painful immune disorder is basically entirely cured by it - it completely changed my life, making even sleeping far better. But not just me, I have friends who have lifelong terrible allergies gone, lifelong pack-a-day smoking addictions completely gone, and so on...

"Not really" is truly either the most pessimistic take I've ever heard, or hopefully just completely misinformed.

nwienert commented on Semaglutide improves knee osteoarthritis independant of weight loss   cell.com/cell-metabolism/... · Posted by u/randycupertino
CoastalCoder · a day ago
If it can somehow restore spinal disc function, I'm gonna start snorting the stuff.
nwienert · a day ago
It's a miracle drug for reducing immune overreach, like better than anything we know of. This is also completely outside of the weight loss effects. My lower back is improved by it.

It'll come to be known that these drugs are far better for people in a broad way than even thought today. They seem to have at least 4 effects that individually should be considered a "miracle."

nwienert commented on The Waymo World Model   waymo.com/blog/2026/02/th... · Posted by u/xnx
nfg · 5 days ago
I’d suggest doing some research on software quality. Two years back I was all for buying one (I was considering an EX40), but I got myself into some Facebook groups for owners and was shocked at the dreadful reports of quality of the software and it completely put me off. I got an ID4 instead. Reports about the EX90 have been dreadful. I was very interested, and I still admire their look and build when they drive by - but it killed my enthusiasm to buy one for a few years until they get it right.
nwienert · 5 days ago
Software is pretty solid as of latest release. EX90 is a sleeper pick now because of the bad press being behind the latest software.
nwienert commented on Claude Opus 4.6   anthropic.com/news/claude... · Posted by u/HellsMaddy
jpcompartir · 5 days ago
4.6 is a beast.

Everything in plan mode first + AskUserQuestionTool, review all plans, get it to write its own CLAUDE.md for coding standards and edit where necessary and away you go.

Seems noticeably better than 4.5 at keeping the codebase slim. Obviously it still needs to be kept an eye on, but it's a step up from 4.5.

nwienert · 5 days ago
Not clearly a step up for me, it's way more hesitant it seems and I don't notice context being larger at all it seems to compact just as often.
nwienert commented on Tesla kills Autopilot, locks lane-keeping behind $99/month fee   arstechnica.com/cars/2026... · Posted by u/CharlesW
fartfaceMcgee · 19 days ago
How you like that car? I test drove an early model that was really a pre-release dealer demo. It was a great ride but I also didnt get to do a whole lot with the sales guy next to me and a tight deadline to get back home.
nwienert · 18 days ago
Made me want to invest in Volvo. They fixed most of the software issues, what's left is a shockingly nice experience. Touch screen can be a bit annoying is all, but Google integration and design of the UX in the touchscreen is really good.
nwienert commented on Tesla kills Autopilot, locks lane-keeping behind $99/month fee   arstechnica.com/cars/2026... · Posted by u/CharlesW
Waterluvian · 19 days ago
I have a 2020 Forester and I've come to describing it as "I no-longer drive on the highway, I manage the car." Sometimes I'll get nervous and take over. But even in stop-and-go traffic, it has behaved perfectly.

My only complaint is that there's an over-eager PID loop with lane keeping. If I want to pass a transport truck and want to kind of edge to the left of my lane when doing so, it will keep trying to compensate, which I can feel in the wheel, so I compensate for as well. And if I let go of the wheel and let it win, it suddenly flings me towards the right side of the lane.

I suspect this is because it isn't programmed to think that I'm making adjustments, it probably just thinks there's some weirdness in the vehicle dynamics/road characteristics that requires extra compensation.

nwienert · 19 days ago
Have a EX90 I got on a really great deal, we drove it cross-country and it was mind-blowing how little I had to do. If it didn't make you touch the wheel / pay attention we could have basically done the entire trip without incident minus off-ramps.

But there was one thing that was quite bad, similar to yours. While passing a semi I pulled it to the left side and it actually yanked us right so hard and then over-corrected once again. Super scary moment, the only issue of the whole trip, but basically never passed with it on again.

nwienert commented on Anthropic made a mistake in cutting off third-party clients   archaeologist.dev/artifac... · Posted by u/codesparkle
joelthelion · a month ago
650,000 monthly active users is not "extremely small". I wonder how many total users Claude Code has?
nwienert · a month ago
I'm referring to the ones willing to cancel, especially ones who also feel the need to make a public statement about it. And I'd guess your number is high % churn, and even still CC is much higher.

u/nwienert

KarmaCake day4830March 30, 2011
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