There seem to be some interesting efforts to run SQLite in the browser so that server infrastructure only has to provide bulk data access, with precomputed indices to avoid full table scans; I wonder if those might be applicable here: https://blog.ouseful.info/2022/02/11/sql-databases-in-the-br... (though of course if you aren't using SQLite as your backend now it might be a headache)
Such an approach, if it were feasible, would have the advantage that bulk data downloads wouldn't look very different from normal use.
Short answer to your question is that the API load should be fine (I regularly download large subsets of the database myself via the API for research purposes), although there are good and bad ways of writing API queries. We have some tutorials, workshops, etc. available to help newcomers to our API write good queries.
We also have an email address set up (heavy.api.use@materialsproject.org) where people can give us a heads up if they are concerned about putting an undue load on our servers; as much as we try to have reasonable automatic limits set, sometimes we have had issues! API traffic continues to grow too, which in some ways is a nice problem to have, but does mean this is a moving target.
Create a simulation, down to the quantum states, of a lattice of molecules at a certain simulated temperature (say, room temperature), and induce a simulated current through the lattice, and see if it superconducts. Proceed by iterating through billions of permutations of compounds in the simulated lattice, until the simulation finds a room-temperature superconductor.
Assuming this is feasible, does anyone know of organizations that are doing this?
Materials Project is funded by the US Department of Energy and uses supercomputing to simulate hundreds of thousands of different crystal structures on the quantum mechanical level to try and find those which have useful properties for practical applications.
This line of research is broadly called “materials discovery”, “materials design” (often “high throughput”) or even “materials genomics” depending on who you ask. These terms are provided in case anyone wants to search and read more about it.
[0] https://materialsproject.org