You're going to want persistent storage on your server, not ephemeral. You'll also want NVME. A lot of the time you're going to end up on bare metal running a single server anyway.
You're going to have down time for migrations unless you're very clever with your schema and/or replicas.
Litestream for me at least is what makes SQLite viable for a web app as prior to that there wasn't a good replication story.
With litestream it's much easier to have a backup on standby. That being said where I have used it in production some amount of downtime has been acceptable so mileage may vary.
probably worth stating these kinds of design considerations/assumptions up-front
i'm sure lots of applications are fine with "downtime for [database] migrations" but lots more are definitely not, especially those interested in synthetic metrics like TPS
You can achieve zero downtime with Sqlite if you really need to.
TPS is not a synthetic metric when you cap out at 100 TPS because of Amdahl's law and your users having a power distribution.
taking a step back, if your application's db requirements can be satisfied by sqlite [+replication] then that's great, but that set of requirements is much narrower, and much easier to solve, than what postgres is for