I always wonder if some of the self reported dosage variability for pills comes from differences in absorbtion of pills. Maybe some ppl's stomach acids or bacterial flora destroy particular molecules more or prevents absorption more than in other ppl?
you can see this with pot edibles, if you take one on an empty stomach it takes forever to kick in and sometimes doesn’t work very well, but if you eat the same one after a large fatty meal it will kick in fast and strong