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dmclamb commented on Scientists achieve more than 98% efficiency removing nanoplastics from water   showme.missouri.edu/2024/... · Posted by u/Ozarkian
dmclamb · a year ago
Tangentially related, I'd love to see some form of per product microplastic rating for food and drinks, similar to nutritional facts.

I am finding bread products are often wrapped in two layers of plastic.

That can't be good.

dmclamb commented on Source code for Quake 2 rerelease   github.com/id-Software/qu... · Posted by u/steveklabnik
karim79 · 2 years ago
Incredible and just sent me way back to the nineties. To be fair, I'm talking about the first Quake game here. I had a PC rig on my bedroom floor which as I recall was a Pentium 166MMX, and my friend came over with a similar machine which was a bit faster (a 233) perhaps. No LAN cards insight.

Using one of my dad's ancient parallel cables and fooling Windows into thinking it was a LAN connection, which worked well enough, we played for days, until it got kind of tedious. So we then got into the whole modding scene - not creating anything, but downloading and testing the things which were out there. I will never, ever forget Girobot and KQP (Killer Quake Patch).

The Girobot bots were a force to be reckoned with when they didn't get stuck in the terrain. It was KQP which added all kinds of crazy mods/weapons/bot systems to the game that was the real gold. The Vampire Gun left us in stitches every time someone was hit by it, because it basically guaranteed a slow but not too slow death in which the hit player would crumble into little chunks of flesh. I miss the nineties very, very much.

dmclamb · 2 years ago
my dad's ancient parallel cables

With a null modem? I had same setup with my college roommate in our apartment. This was mid 90s, so it was Doom 2 and other FPS from that time.

Great memories.

dmclamb commented on Early-life stress can disrupt maturation of brain’s reward circuits   news.uci.edu/2023/02/27/e... · Posted by u/gmays
dmclamb · 3 years ago
This resonates with my experience of learned helplessness, especially when instilled within the first two years of life.

The analogy that comes to mind is how a baby elephant, tied to a stake, can't escape the rope and eventually accepts he is stuck where the rope lets him wander. As the elephant grows large enough to overpower the rope and walk away, he has already stopped trying, so he remains stuck.

I'm not sure if this is a true story, but it stays with me.

It seems reasonable to conclude there is a physical impact on brain development.

dmclamb commented on Ask HN: HNers with multiple sclerosis, can we get in touch?    · Posted by u/mush_room
dmclamb · 3 years ago
I'm 50. Diagnosed with MS at 40. Symptoms began around 19. Still working full time but live never knowing for how much longer.

MS sucks.

Things I have found helpful for me, ymmv: cando-ms Ocrevus Ampyra Eliminate processed foods, eat lots of fruits/veggies Exercise the parts of the body that can still move John Kabat -Zinn, mindfulness meditation for pain management Sleep Get outdoors a few minutes every day Participate in clinical trials Meet with others fighting MS who still hold on to hope, and can still laugh and cry

Things I believe that may not be true EBV virus/mononucleosis plays a significant role in my MS Still unknown, but there is interesting science on this. I tried to qualify for a study on ATA188, which kills EBV infected immune cells, but did not qualify.

I wish you well.

dmclamb commented on MS reversed by transplanted immune cells that fight Epstein-Barr virus   newscientist.com/article/... · Posted by u/eecc
dmclamb · 4 years ago
Is this ATA188? The clinical trial is open for that med which targets epv infected cells.
dmclamb commented on What happens to developers who never go into management?   wbscodingschool.com/what-... · Posted by u/pelasaco
dmclamb · 4 years ago
Transition to information security. A challenging career that may pay well.
dmclamb commented on E-Ink Magic Calendar that runs off a battery powered Raspberry Pi   github.com/speedyg0nz/Mag... · Posted by u/edward
dmclamb · 4 years ago
Why not use a raspberry pi connected to an hdtv to display this, weather, news, etc.? You could make one HDMI port the "what's happening" channel.

Plus run pinhole.

dmclamb commented on MS treatment a step closer after drug shown to repair nerve coating   theguardian.com/society/2... · Posted by u/pujjad
chime · 5 years ago
> While bexarotene will not go into phase 3 trials for MS, the finding that the nervous system can be stimulated to resheath damaged neurons has given scientists fresh hopes for another trial they hope to launch later this year. That trial will monitor the effects of the diabetes drug metformin along with clemastine, an antihistamine, a combination that Prof Robin Franklin at the Wellcome-MRC Cambridge Stem Cell Institute showed last year could drive remyelination in animals.

That would be an amazing find if it works in humans. My wife was on metformin for many years (not for diabetes) before being recently diagnosed with MS. Coincidentally she experienced her first MS symptoms shortly after stopping metformin. We suspect that use of prescription steroids along with metformin might have been masking the onset of her MS for years and in an indirect way even delayed it slightly.

She just got her first half-dose infusion of Ocrevus, other half scheduled for next week. Ocrevus is such an amazing disease-modifying drug. It's very expensive but our insurance covers it and after the initial dose, she only needs one 3-4 hour infusion every 6 months. No other medication needed on a daily basis! Ocrevus helps ensure no new flare-ups happen anytime soon but it leaves her immunocompromised and there is no remyelination. If metformin + antihistamine end up producing even a little bit of remyelination that would be a game changer because she's young and has enough time to regain everything if it just involves taking a couple of pills daily.

Unrelated but just putting this out there since it's fresh on my mind - if you or loved one ever gets diagnosed with MS or equivalent, you absolutely have to be your own advocate. Best thing you can do in the US is to get an online fax# (I use redfax) and the Dropbox app. Scan every single medical document you get with the Dropbox app, convert it to PDF, and then fax it over to 100 places as needed. Also sign up for every single patient portal including Quest/Labcorp. Be sure to get a DVD of every imaging test (CT/MRI) and upload them for free to postdicom.com to share with anyone or to just see it yourself if curious.

It is a LOT of work and very stressful. But if you're technically savvy, you can avoid a lot of driving back and forth between testing, doctor, hospital, medical centers. And above all reach out to anyone you trust for assistance, even if it's just to pick up groceries. People can surprise you with their generosity.

dmclamb · 5 years ago
I'm RRMS, year three on Ocrevus. I wish your wife well. MS is a cruel disease.

u/dmclamb

KarmaCake day35October 29, 2018View Original