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darthvoldemort commented on Ask HN: Whatever happened to Wolfram Alpha?    · Posted by u/zandorg
darthvoldemort · 4 years ago
I think Siri gets some of its results from Wolfram Alpha.

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darthvoldemort commented on Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%   fiercebiotech.com/biotech... · Posted by u/jeremylevy
dang · 4 years ago
You broke the site guidelines badly with this, and we ban accounts that do that. Please don't do this again.

If you'd please review https://news.ycombinator.com/newsguidelines.html and stick to the rules when posting here, we'd appreciate it.

darthvoldemort · 4 years ago
Dan, you're protecting tptacek from criticism which is absolute bullshit. I very fairly criticized his lack of reading comprehension, and the fact he's not an expert in anything except for security. What he accused me of in his comments was worse and protecting him is bullshit.

He came in attacking me twice and you do nothing to his account? He didn't even read my post and then started his rant about the vaccine when I wasn't even talking about the vaccine.

If you're going to threaten with banning, I suggest you do it to everyone fairly, even if he's one of your "favorites". You should be flagging his posts, not mine.

Plus, you flagged my perfectly accurate post on how thalidomide is safe, it's the chiral version of it that causes deformities?

darthvoldemort commented on Ask HN: How were video games from the 90s so efficient?    · Posted by u/eezurr
pan69 · 4 years ago
Michael Abrash's Graphics Programming Black Book Special Edition

https://www.phatcode.net/res/224/files/html/index.html

darthvoldemort · 4 years ago
I have this book, it was such an important and informative book at the time. It's so interesting that such an important book filled with a wealth of knowledge doesn't have much use these days.

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darthvoldemort commented on Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%   fiercebiotech.com/biotech... · Posted by u/jeremylevy
cglace · 4 years ago
Are you suggesting that every new molecule should be treated as if it were a prion?
darthvoldemort · 4 years ago
I'm suggesting that sometimes a very small amount of a substance can cause catastrophic effects a decade later. That's why we do testing before we release drugs.

And Pfizer isn't the hero here, they never have been.

https://corporatewatch.org/pfizer-six-scandals-to-remember/

This list doesn't even include Celebrex.

1986: Pfizer had to withdraw an artificial heart valve from the market after defects led to it being implicated in over 300 deaths. The US Food and Drug Administration (FDA) withdrew its approval for the product in 1986 and Pfizer agreed to pay hundreds of millions of dollars in compensation after multiple lawsuits were brought against it.

2003: Pfizer has long been condemned for profiteering from AIDS drugs. In 2003 for example, it walked away from a licencing deal for its Rescriptor drug that would have made it cheaper for poorer countries.

2011: Pfizer was forced to pay compensation to families of children killed in the controversial Trovan drug trial. During the worst meningitis epidemic seen in Africa, in 1996, Pfizer ran a trial in Nigeria their new drug Trovan. Five of the 100 children who took Trovan died and it caused liver damage, while it caused lifelong disabilities in those who survived. But another group of 100 children were given the conventional “gold standard” meningitis antibiotic as a “control” group for comparison. Six of them also tragically died because, the families said, Pfizer had given them less than the recommended level of the conventional antibiotic in order to make Trovan look more effective.

2012: Pfizer had to pay around $1billion to settle lawsuits claiming its Prempro drug caused breast cancer. Prempro was used in hormone replacement therapy, usually for women going through the menopause. The settlements came after six years of trials and hardship for the women affected.

2013: Pfizer paid out $273 million to settle over 2,000 cases in the US that accused its smoking treatment drug Chantix of provoking suicidal and homicidal thoughts, self harm and severe psychological disorders. Pfizer was also accused of improperly excluding patients with a history of depression or other mental disturbances from trials for the drug. Later, in 2017, a coroner in Australia ruled that the drug had contributed to a man’s suicide. The man’s mother campaigned to change the label on the drug.

2020: Pfizer reached an agreement with thousands of customers of its depo-testosterone drug in 2018 after they sued it for increasing the likelihood of numerous issues, including heart attacks.

darthvoldemort commented on Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%   fiercebiotech.com/biotech... · Posted by u/jeremylevy
wonderwonder · 4 years ago
Interesting. From a quick google search: Pfizer brands include Advil, Bextra, Celebrex, Diflucan, Lyrica, Robitussin and Viagra

You never take an advil?

darthvoldemort · 4 years ago
Pfizer also made Celebrex, the anti-inflammatory that they knew caused health issues but they buried them and claimed it was safe.

We are living in an upside down world now. All of a sudden the drug companies are the "good" guys. Since when did the drug companies suddenly become the heroes?

https://corporatewatch.org/pfizer-six-scandals-to-remember/

1986: Pfizer had to withdraw an artificial heart valve from the market after defects led to it being implicated in over 300 deaths. The US Food and Drug Administration (FDA) withdrew its approval for the product in 1986 and Pfizer agreed to pay hundreds of millions of dollars in compensation after multiple lawsuits were brought against it.

2003: Pfizer has long been condemned for profiteering from AIDS drugs. In 2003 for example, it walked away from a licencing deal for its Rescriptor drug that would have made it cheaper for poorer countries.

2011: Pfizer was forced to pay compensation to families of children killed in the controversial Trovan drug trial. During the worst meningitis epidemic seen in Africa, in 1996, Pfizer ran a trial in Nigeria their new drug Trovan. Five of the 100 children who took Trovan died and it caused liver damage, while it caused lifelong disabilities in those who survived. But another group of 100 children were given the conventional “gold standard” meningitis antibiotic as a “control” group for comparison. Six of them also tragically died because, the families said, Pfizer had given them less than the recommended level of the conventional antibiotic in order to make Trovan look more effective.

2012: Pfizer had to pay around $1billion to settle lawsuits claiming its Prempro drug caused breast cancer. Prempro was used in hormone replacement therapy, usually for women going through the menopause. The settlements came after six years of trials and hardship for the women affected.

2013: Pfizer paid out $273 million to settle over 2,000 cases in the US that accused its smoking treatment drug Chantix of provoking suicidal and homicidal thoughts, self harm and severe psychological disorders. Pfizer was also accused of improperly excluding patients with a history of depression or other mental disturbances from trials for the drug. Later, in 2017, a coroner in Australia ruled that the drug had contributed to a man’s suicide. The man’s mother campaigned to change the label on the drug.

2020: Pfizer reached an agreement with thousands of customers of its depo-testosterone drug in 2018 after they sued it for increasing the likelihood of numerous issues, including heart attacks.

darthvoldemort commented on Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%   fiercebiotech.com/biotech... · Posted by u/jeremylevy
yosito · 4 years ago
> Side effects don't have to happen in the next 6 months.

If this is a molecule with a short half-life that is broken down and expelled by the body, it isn't going to have random side effects that show up months in the future.

darthvoldemort · 4 years ago
Prions are "just" proteins that should get broken down by the body. But they don't, and they cause ‎Creutzfeldt-Jakob in over 10 years after ingesting.
darthvoldemort commented on What I learned from a year on Substack   niemanlab.org/2021/09/wha... · Posted by u/wyclif
jaredwiener · 4 years ago
Picking up on a conversation from a while ago: https://news.ycombinator.com/item?id=28866626

If any newsroom brass is reading this (or reporters thinking of going independent, especially local) -- I'd love to talk. We're building a platform to help monetize journalism outside of the usual predatory social media/aggregator set up, and with more support than Substack.

jared (at) nillium (dot) com

darthvoldemort · 4 years ago
I'm skeptical about the idea that Substack has poor support.

I just listened to Chuck Palahniuk on Joe Rogan. He still writes on pads of paper, but he said Substack hand-held him and he loved it, and called Substack a "concierge service" and he said he enjoys Substack because it let's him concentrate on writing and not worrying about the tedious parts like formatting, etc.

u/darthvoldemort

KarmaCake day623September 9, 2021View Original