Basicially QPX Express was always a paid and also very limited version of matrix.itasoftware.com
Instead the results were much better (and free) just scraping ITA and being able to enter all those advanced routing codes. Great way for finding error fares, fuel dumps, ... And there was no spam check from google's side, no IP request restrictions, no limit, nothing, whatsoever. The code is a bit hard to go with when they changed to ITA v3 but once you figured it out (and it took us only 2 days since we had a working scraper for the previous version) to adjust it to the new code.
So naturally I'm quite impressed with Fareportal and will give it a try. I did do a quick search on CheapOair and didn't see Ryanair among the results (although they do have a flight for that route and date). I know they're icky about third parties advertising/[re]selling their flights but there's some suppliers that do carry their flight data (ie Travelfusion, which politely told me to come back once I have a working product, chicken and egg much?).
I'm not keen to book flights on behalf of users at this point since I have a (not thoroughly documented) fear that regulatory matters will make it difficult/expensive to operate an indie OTA but that's TBD.
I also got an email the other day from http://mystifly.com which also promotes LCC but I haven't tested them yet.
You're only likely to be in a Sabre system if you've been booked by your company through a travel agent and rent using legacy car/hotel companies also through your company's travel agent.
Its actually the other way around, some airlines have their own system, but most use some sort of GDS.
i.e. even when you make a booking directly with one of the airlines above mentioned, the entire PNR is still created and used in a GDS.
Even when you use Farelogix (for LH NDC bookings for example) the entire PNR also gets created in AMA. When you want to make changes in the LH PNR that FLX does not support yet, you still have to make the changes in the AMA PNR.