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cthalupa commented on FDA intends to take action against non-FDA-approved GLP-1 drugs   fda.gov/news-events/press... · Posted by u/randycupertino
koolba · 12 hours ago
There’s nothing systemic about overeating at an individual level. It’s a personal choice to have that extra donut or cola. Nobody is forcing it down your throat nor shaming you for refusing.

Quite the contrary with segments of modern society trying to normalize obesity.

cthalupa · 10 hours ago
I believe that in a vacuum, any human being on the planet can lose weight.

I also believe that we don't live in a vacuum and context matters. The fact that we consistently see people who have a lifetime of being a healthy weight gain significant weight when they move to countries with high obesity rates means that there obviously is something more to this than just "have more willpower bro"

cthalupa commented on Noam Chomsky's wife responds to Epstein controversy   aaronmate.net/p/noam-chom... · Posted by u/Red_Tarsius
KingOfCoders · 12 hours ago
The question never is: Did you know? But: Should you have known? Willfully ignoring things is not a defense.
cthalupa · 12 hours ago
I don't have enough information to answer that or the time to research it, and indeed, this is part of my point.

And thus why I'm writing the whole lot of them off it looks like they had real interaction with Epstein.

cthalupa commented on Noam Chomsky's wife responds to Epstein controversy   aaronmate.net/p/noam-chom... · Posted by u/Red_Tarsius
INTPenis · 12 hours ago
But wait, there's more, also a strange explanation about 270000 dollars being sent from Epstein to Chomsky. Apparently something had happened to Chomsky's retirement fund, and Epstein was helping him recover money?!

It makes no sense to me.

Honestly, Chomsky I am willing to believe unconditionally. He has spent his entire life speaking out on US imperialism, and Israel. His career is longer than Epstein's whole life.

Tinfoil hat on, I'd rather believe this was Israels attempt to discredit Chomsky, through Epstein.

cthalupa · 12 hours ago
> Regarding the reported transfer of approximately $270,000, I must clarify that these were entirely Noam’s own funds. At the time, Noam had identified inconsistencies in his retirement resources that threatened his economic independence and caused him great distress. Epstein offered technical assistance to resolve this specific situation.

Yeah. What? This paragraph answers nothing and just raises more questions. Epstein just magically walked Noam through making 270k just reappear in his account? This is played off like he accidentally sent a quarter of a million dollars to his checking account instead of his savings account and Epstein told him how to use the bank's website to transfer funds between the two.

cthalupa commented on Noam Chomsky's wife responds to Epstein controversy   aaronmate.net/p/noam-chom... · Posted by u/Red_Tarsius
cthalupa · 12 hours ago
It's very easy to believe that Epstein cultivated a massive quantity of relationships with any sort of rich, famous, influential, or powerful person he could. It's very easy to believe that many of them, for much of his existence, had no idea what was really going on. It's very easy to believe that plenty of "normal" (for relative values of normal here) people had no idea how to act when this all came to light and just shut up and avoided it and hoped none of this ever surfaced.

But we also know a whole fucking lot of them did know exactly what was going on and partook in some manner.

And as an everyday person who can realistically make zero impact on any of these people? Fuck if I've got the time to try and sort out which person falls into which group. The courts can figure that out if they actually start doing anything about all of this.

For me? I'm writing 'em all off.

cthalupa commented on FDA intends to take action against non-FDA-approved GLP-1 drugs   fda.gov/news-events/press... · Posted by u/randycupertino
notesinthefield · 13 hours ago
Im aware from the BPC research from the last few years. No history of cancer.
cthalupa · 13 hours ago
Just posting for general awareness - people search this stuff up and then find nothing but research chem sites singing the benefits and providing no info on the risks.

I've had great success with BPC-157 and tendon issues, but I try to use it sparingly - no history of cancer, but everyone has no history of cancer until they do - and try to rehab any injuries with slow heavy eccentrics, etc., and only go for the BPC when that isn't making any improvement.

cthalupa commented on FDA intends to take action against non-FDA-approved GLP-1 drugs   fda.gov/news-events/press... · Posted by u/randycupertino
notesinthefield · a day ago
I would silly things to hold onto a steady supply of pentadeca arginate. It has completely eliminated lingering effects of joint and ligament injury and has enabled me to exercise like a normal person. If you have the money it is very easy to acquire a year or twos worth from multiple sources.
cthalupa · 16 hours ago
Dangerous to use if you have any cancerous or pre-cancerous growths in your body, though. We know they love VEGF, and BPC-157/PDA majorly amp it up.
cthalupa commented on FDA intends to take action against non-FDA-approved GLP-1 drugs   fda.gov/news-events/press... · Posted by u/randycupertino
dboreham · 20 hours ago
The fact that they could sell in the first place I think implies some corruption occurred at some point in the past that permitted them to do so (not necessarily by them, but someone must have lobbied for "compounding" since that afaik doesn't exist in other proper countries). Then they failed to pay the necessary bribe to be allowed to continue. To be fair, the bribe would have been very large given the GLP-1 manufacturers' position in the pension savings of ordinary Americans.
cthalupa · 16 hours ago
Compounding pharmacies are in many ways just a continuation of the original apothecaries and pharmacies, and the US is hardly the only country with the legal framework that allows this.

Australia was basically a carbon copy of the US in this regard until 2024, but they have specifically started targeting a lot of the "wellness" compounding that includes peptides, GLP-1s, etc. since then.

Germany has two classes of pharmacy that are nearly the exact same as 503A and 503B compounders in the US

Canada is similar but stricter about the big pharmacies turning into de facto manufacturers, pumping out huge quantities for downstream compounders and clinics, which is what happened in the US.

Lots of other countries that you might not consider "proper countries" (whatever that means) follow a very similar system to the US, and lots of countries that allow some form of compounding, like the UK through their "specials" program, but it's much more centralized - basically cutting out the 503A compounders in the US.

Fundamentally compounding pharmacies offer pretty important services - there are people out there that would literally not be able to take the most effective medication for their condition without the compounding pharmacies making formulation changes that the larger manufacturers might not have incentive to make. Their existence quite literally saves lives. So it becomes a matter of not making that so restrictive that you wind up killing people due to restricted access vs. letting it get abused in situations like we're seeing today with tirzepatide and semaglutide.

cthalupa commented on FDA intends to take action against non-FDA-approved GLP-1 drugs   fda.gov/news-events/press... · Posted by u/randycupertino
loeg · a day ago
> There has also been cases of compounding pharmacies offering reta and other unapproved peptides

Can you elaborate more on this? I hadn't heard about it.

cthalupa commented on FDA intends to take action against non-FDA-approved GLP-1 drugs   fda.gov/news-events/press... · Posted by u/randycupertino
Balgair · a day ago
My company makes HPLCs.

Yes, they can 'prove' what is in something to the limits of the physics.

However, the human in the loop is quite frail for most operators. In that, these very fancy and very expensive instruments are mostly run by high school grads and serviced by field engineers with a huge backlog.

For a first time one off test of something's composition, I'd go for at least 3 companies and preferably you have a history with them. This stuff is terribly complicated and misinterpretation is shockingly common. If the tech hasn't used the standards before then your at the mercy of fate.

Like, we have 5 (!) places on the home screen that do the exact same function of ending a run because when we try to consolidate it to just 1, our customers freak out and can't find where the button went to. Granted they pay $100k+ per instrument plus service plan, so we add it back in no question ( and this is life critical equipment in many cases), but I hope that shows how embedded to routine these operators get.

cthalupa · 21 hours ago
Janoshik is the primary company people use here, and their business is basically entirely peptides and anabolic steroids, and the GLP-1 stuff exploded their business from gym bros to soccer moms everywhere. https://janoshik.com/

But they basically test the same 12ish compounds day in and day out, with another couple of dozen making up the remainder. They don't have most of the worries that you are referring to - first time for a tech running a specific set of standards, limited experience interpreting them, etc., and when people head to head their results against different labs, they are consistent.

cthalupa commented on FDA intends to take action against non-FDA-approved GLP-1 drugs   fda.gov/news-events/press... · Posted by u/randycupertino
rootusrootus · a day ago
The Atlantic did a write-up in December [0] about retatrutide availability and they named at least one well known vendor (who also sells tirzepatide, semaglutide, and all the other usual peptides). Not the cheapest vendor, but well known, does the batch lyophilization in the US, still takes credit cards, and gets pretty solid group test participation due to their popularity. And if you know how their pre-sales work, the price premium isn't too terrible, worth it for the test participation IMO.

If you want to know who else to avoid, join the Discord the vendor links to from their web page and ask around in the general discussion topics, people will share.

[0] https://archive.ph/n0daP

cthalupa · a day ago
> does the batch lyophilization in the U

Nexaph does not lyophilize in the US despite Cain's claims - if you're buying from Nexaph, do so because they're popular and well tested by 3rd parties, but not off of anything they're saying about themselves. Hell, just go to the About page and you can find an artifact from back when Cain was lying about Nexaph being a chinese pharma company that had mRNA vaccine production experience.

That's also why the "presale" periods are cheaper - just letting them know how many vials to put in an order for.

u/cthalupa

KarmaCake day5688April 24, 2014
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